Abstract: System and a method for computer-aided therapy for treating type 2 diabetes, insulin resistance and/or restoring glucose homeostasis in a subject in need thereof, using a main frame that receives a subject profile; receives a set of images associated with the subject; processes PET and CT images for obtaining a 2D distribution of the quantitative density of the GLP-1r along the portal vein; and identifies a region with lower GLP-1r along the portal vein for which the values of the 2D distribution are less than a given threshold and for which the 2D distribution is less than or equal to a reference value; the threshold being based on the distribution of GLP-1r along the portal vein.

Abstract: The present invention relates to a bioactive molecule upregulating GLP-1r for use in treating insulin resistance and/or restoring glucose homeostasis by local administration to the peri-portal region of the portal vein.

Abstract: A process for producing a polymeric article is provided that includes: sequentially filling a female mould (11) with a first, second, and third batches, wherein the first and third batches include first and third polymeric materials (1p, 3p), and the second batch includes a second polymeric material (2p) and a blowing agent (2b), closing the thus filled cavity with a lid (12) to form a mould defining a closed cavity (10c) of constant volume in time, heating the mould (10) to a processing temperature, to melt the first, second, and third polymeric materials (1p-3p) and to expand the second polymer agent by activation of the blowing agent, cooling and removing the lid (12) to open the cavity and extracting the polymeric article. At least the second polymeric material (2p) includes at least 50 wt. % of recycled polymer in the form of shredded flakes.

Abstract: A process for producing a polymeric article is provided that includes: sequentially filling a female mould (11) with a first, second, and third batches, wherein the first and third batches include first and third polymeric materials (1p, 3p), and the second batch includes a second polymeric material (2p) and a blowing agent (2b), closing the thus filled cavity with a lid (12) to form a mould defining a closed cavity (10c) of constant volume in time, heating the mould (10) to a processing temperature, to melt the first, second, and third polymeric materials (1p-3p) and to expand the second polymer agent by activation of the blowing agent, cooling and removing the lid (12) to open the cavity and extracting the polymeric article. At least the second polymeric material (2p) includes at least 50 wt. % of recycled polymer in the form of shredded flakes.