Abstract: The present invention relates to a bioactive molecule upregulating GLP-1r for use in treating insulin resistance and/or restoring glucose homeostasis by local administration to the peri-portal region of the portal vein.

Abstract: A process for producing a polymeric article is provided that includes: sequentially filling a female mould (11) with a first, second, and third batches, wherein the first and third batches include first and third polymeric materials (1p, 3p), and the second batch includes a second polymeric material (2p) and a blowing agent (2b), closing the thus filled cavity with a lid (12) to form a mould defining a closed cavity (10c) of constant volume in time, heating the mould (10) to a processing temperature, to melt the first, second, and third polymeric materials (1p-3p) and to expand the second polymer agent by activation of the blowing agent, cooling and removing the lid (12) to open the cavity and extracting the polymeric article. At least the second polymeric material (2p) includes at least 50 wt. % of recycled polymer in the form of shredded flakes.

Abstract: A process for producing a polymeric article is provided that includes: sequentially filling a female mould (11) with a first, second, and third batches, wherein the first and third batches include first and third polymeric materials (1p, 3p), and the second batch includes a second polymeric material (2p) and a blowing agent (2b), closing the thus filled cavity with a lid (12) to form a mould defining a closed cavity (10c) of constant volume in time, heating the mould (10) to a processing temperature, to melt the first, second, and third polymeric materials (1p-3p) and to expand the second polymer agent by activation of the blowing agent, cooling and removing the lid (12) to open the cavity and extracting the polymeric article. At least the second polymeric material (2p) includes at least 50 wt. % of recycled polymer in the form of shredded flakes.