Abstract: The present invention relates to a fusion protein in which transferrin is peptide-bonded to a terminal of a granulocyte-colony stimulating factor (G-CSF) protein or a G-CSF mutant protein in which the 116th threonine is substituted with cysteine in the amino acid sequence of the G-CSF. Specifically, the granulocyte-colony stimulating factor (G-CSF) mutant protein of the present invention or the transferrin fusion protein thereof displays a significantly increased specific activity and blood stability, compared with the conventional human G-CSF, and has a higher purification efficiency than the conventional PEGylated G-CSF characterized by the extended half-life, so that it can be advantageously used for preventing or treating ischemic diseases or neutropenia.

Abstract: A method and apparatus for rapidly locating a desired object in a bit-mapped or vector display listed object space, wherein additional information is appended to or stored with the object information. This additional information relates to the relative coordinate position of that object or object element within a larger, more coarsely defined object space grid, such as an 8.times.8 grid. The apparatus and method of the present invention reduces the processing time necessary to locate the desired object within the object space by comparing the object and display area information relative to the grid for rapid preliminary acceptance or rejection prior to further detail search for the object or object elements.