Abstract: Catheters for isolating an interior of a mammal hollow organ, each comprising: (i) an elongate catheter body designed to be inserted into a lumen of the mammal hollow organ; (ii) two balloons individually and separately disposed along the catheter body and designed to be inflated to isolate the interior of the mammal hollow organ therebetween; and (iii) a functional channel extending in the catheter body and comprising a functional opening provided in the catheter body between the balloons; wherein the functional channel is designed to allow a negative pressure to be produced in the isolated interior to take a liquid or gaseous medium therefrom via the functional opening or allow a liquid or gaseous medium to be supplied to the isolated interior via the functional opening.