Patents Assigned to Pangaea Pharmaceuticals, Inc.
  • Microparticles for delivery of nucleic acid
    Patent number: 5783567
    Abstract: Disclosed is a preparation of microparticles made up of a polymeric matrix and a nucleic acid expression vector. The polymeric matrix includes one or more synthetic polymers having a solubility in water of less than about 1 mg/l. At least 90% of the microparticles have a diameter less than about 100 microns. The nucleic acid is either RNA, at least 50% of which is in the form of closed circles, or circular DNA plasmid molecules, at least 50% of which are supercoiled.
    Type: Grant
    Filed: January 22, 1997
    Date of Patent: July 21, 1998
    Assignee: Pangaea Pharmaceuticals, Inc.
    Inventors: Mary Lynne Hedley, Joanne M. Curley, Robert S. Langer