Abstract: The present invention provides anti-nerve growth factor (NGF) antibodies that contain an IgG4 constant region comprising a stabilizing hinge region mutation and wherein the antibodies exhibit an unexpectedly long serum half life in cynomolgus monkeys. Pharmaceutical compositions comprising the anti-NGF antibodies, nucleic acids encoding the NGF antibodies, host cells for expressing the NGF antibodies and methods of using the antibodies for treating NGF-related diseases or conditions are also provided.
Type:
Application
Filed:
May 4, 2010
Publication date:
November 4, 2010
Applicant:
PANGENETICS 110 BV
Inventors:
John Powell, Duncan Casson, Mark Maginn, Wei Liu, Sandeep Dutta, Andrea Best, Jerry A. Hall