Patents Assigned to Pangenetics BV
  • Gene constructs coding for CD40-binding activating antibodies
    Patent number: 7820807
    Abstract: Disclosed are agonist anti-CD40 molecules, including monoclonal antibodies, which can bind to and stimulate professional and non-professional human antigen-presenting cells (“APCs”), enhance the stimulatory effect of CD40L on CD40 positive cells and/or induce phenotypical maturation of monocyte derived dendritic cells. Several such monoclonal antibodies are provided, and cell lines producing them have been deposited at the American Type Culture Collection.
    Type: Grant
    Filed: April 8, 2009
    Date of Patent: October 26, 2010
    Assignee: Pangenetics BV
    Inventors: David Thomas, Mark De Boer, Pieter C. J. M. Res, Peter J. Simons
  • CD40-BINDING ACTIVATING ANTIBODIES
    Publication number: 20090311268
    Abstract: Disclosed are agonist anti-CD40 molecules, including monoclonal antibodies, which can bind to and stimulate professional and non-professional human antigen-presenting cells (“APCs”), enhance the stimulatory effect of CD40L on CD40 positive cells and/or induce phenotypical maturation of monocyte derived dendritic cells. Several such monoclonal antibodies are provided, and cell lines producing them have been deposited at the American Type Culture Collection.
    Type: Application
    Filed: April 8, 2009
    Publication date: December 17, 2009
    Applicant: Pangenetics BV
    Inventors: David Thomas, Mark de Boer, Pieter C.J.M. Res, Peter J. Simons
  • CD40-binding activating antibodies
    Patent number: 7547438
    Abstract: Disclosed are agonist anti-CD40 molecules, including monoclonal antibodies, which can bind to and stimulate professional and non-professional human antigen-presenting cells (“APCs”), enhance the stimulatory effect of CD40L on CD40 positive cells and/or induce phenotypical maturation of monocyte derived dendritic cells. Several such monoclonal antibodies are provided, and cell lines producing them have been deposited at the American Type Culture Collection.
    Type: Grant
    Filed: December 20, 2006
    Date of Patent: June 16, 2009
    Assignee: Pangenetics BV
    Inventors: David Thomas, Mark De Boer, Pieter C. J. M. Res, Peter J. Simone
  • CD40-BINDING APC-ACTIVATING MOLECULES
    Publication number: 20070098720
    Abstract: Disclosed are agonist anti-CD40 molecules, including monoclonal antibodies, which can bind to and stimulate professional and non-professional human antigen-presenting cells (“APCs”), enhance the stimulatory effect of CD40L on CD40 positive cells and/or induce phenotypical maturation of monocyte derived dendritic cells. Several such monoclonal antibodies are provided, and cell lines producing them have been deposited at the American Type Culture Collection.
    Type: Application
    Filed: December 20, 2006
    Publication date: May 3, 2007
    Applicant: PANGENETICS BV
    Inventors: David Thomas, Mark de Boer, Pieter Res, Peter Simons
  • Induction of cytotoxic T lymphocyte responses using anti-CD40 antibodies
    Patent number: 7172759
    Abstract: Disclosed are methods of inducing maturation of antigen presenting cells and cytotoxic T lymphocyte responses utilizing agonist anti-CD40 antibodies that do not block the binding of CD40L to CD40.
    Type: Grant
    Filed: February 1, 2001
    Date of Patent: February 6, 2007
    Assignee: Pangenetics BV
    Inventors: David Thomas, Mark de Boer, Pieter C. J. M. Res, Peter J. Simons