Abstract: Derivatives of 3,3,5-trimethylcyclohexanol methyl-2-propionate, preparation method, and therapeutical compositions containing them. Such derivatives have general formula (I).
Abstract: Amino acid esters of cycloaliphatic alcohols of the formula: ##STR1## wherein A is cyclohexyl, cyclohexenyl, cyclopentyl, or cyclopentenyl, substituted with from one to three radicals selected from the group consisting of methyl, ethyl and ethenyl. These compounds are useful in treating lipemic disorders.
Type:
Grant
Filed:
January 31, 1992
Date of Patent:
August 17, 1993
Assignee:
Panmedica S.A.
Inventors:
Claude Laruelle, Marcel Lepant, Bernard Raynier
Abstract: The present invention concerns a vanadyl organo-mineral compound which is in the form of a complex of vanadyl and of cystein, having the following general formula: ##STR1## wherein, either x is 1 and y is 0, or x is 0 and y is 1, and wherein n, p and m are respectively integers with a value of 1 or 2.
Type:
Grant
Filed:
February 19, 1991
Date of Patent:
December 29, 1992
Assignee:
Panmedica, S.A.
Inventors:
Rene Lazaro, Gerard Cros, John H. McNeill, Jean-Jacques Serrano
Abstract: Amino acid esters of cycloaliphatic alcohols of the formula: ##STR1## wherein A is cyclohexyl, cyclohexenyl, cyclopentyl and cyclopentenyl, substituted with from one to three radicals which are methyl, ethyl, and/or ethenyl. These amino acid esters have hypolipemic properties.
Type:
Grant
Filed:
December 3, 1990
Date of Patent:
July 28, 1992
Assignee:
Panmedica S.A.
Inventors:
Claude Laruelle, Marcel Lepant, Bernard Raynier
Abstract: The present invention concerns a vanadyl organo-mineral compound which is in the form of a complex of vanadyl and of cystein, having the following general formula: ##STR1## wherein, either x is 1 and y is 0, or x is 0 and y is 1, and wherein n, p and m are respectively integers with a value of 1 or 2.
Type:
Grant
Filed:
August 10, 1988
Date of Patent:
June 11, 1991
Assignee:
Panmedica S.A.
Inventors:
Rene Lazaro, Gerard Cros, John H. McNeill, Jean-Jacques Serrano
Abstract: Drugs with high anticonvulsant and analgesic activities constituted by symmetrical .beta.-dialkoxyiminocycloalklene derivatives in which the imine double bonds are conjugated with the cyclic double bond or bonds belonging to one or more fused benzene rings.
Type:
Grant
Filed:
January 20, 1987
Date of Patent:
February 14, 1989
Assignee:
Panmedica S.A.
Inventors:
Claude Laruelle, Marcel Lepant, Bernard Raynier
Abstract: Alkylcarboxamides of pyridylalkylamines, useful in human and verterinary medicine, correspond to the general formula I: ##STR1## wherein n=0 or 1,R.sub.3 represents an alkyl group of C.sub.1 to C.sub.3 or a hydrogen atom,R.sub.1 represents a hydrogen atom,R.sub.2 represents a group: ##STR2## in which: X and Y are different,X and Y each represent a linear or branched saturated or unsaturated hydrocarbon chain comprising from 1 to 16 carbon atoms;X and Y together determine a saturated or unsaturated cyclic radical substituted or not comprising from 3 to 12 carbon atoms.
Type:
Grant
Filed:
September 18, 1986
Date of Patent:
December 27, 1988
Assignee:
Panmedica
Inventors:
Claude Laruelle, Marcel Lepant, Bernard Raynier
Abstract: The present invention relates to novel antibacterial agents, corresponding to the following general formula I ##STR1## in which: Q represents an aromatic ring,X represents a hydrogen atom or a linear or branched alkyl group,Y represents a linkage or an alkyl group,Z represents a hydrogen atom, an alkyl, aralkyl or heteroalkyl group.These compounds constitute anti-bacterial agents with multiple pharmacological activity.
Type:
Grant
Filed:
June 13, 1986
Date of Patent:
August 16, 1988
Assignee:
Panmedica
Inventors:
Claude Laruelle, Marcel Lepant, Bernard Raynier
Abstract: The present invention relates to new adamantanamine derivatives.These derivatives correspond to the general formula I: ##STR1## in which: R represents hydrogen or a substituted or unsubstituted, linear or branched alkyl radical containing from 1 to 7 carbon atoms.Drugs possessing anticonvulsant properties.
Type:
Grant
Filed:
October 16, 1985
Date of Patent:
April 28, 1987
Assignee:
S. A. Panmedica
Inventors:
Claude Laruelle, Marcel Lepant, Bernard Raynier
Abstract: The present invention relates to new N-acyl derivatives of amino acids.These derivatives correspond to the general formula I below: ##STR1## in which A represents a linear or branched, saturated hydrocarbon radical containing from 1 to 6 carbon atoms or a saturated ring containing 6 carbon atoms,X represents a --COOH radical, a --COOAlkyl radical (alkyl from C.sub.1 to C.sub.4), a hydrogen atom or a --CH.sub.3 group when Y is --COOH or --COOAlkyl,Y represents a --COOH radical, a --COOAlkyl radical (alkyl from C.sub.1 to C.sub.4), an --NH.sub.2 group, an --SH group, an --SCH.sub.3 group, a --NH--CH(.dbd.NH)--NH.sub.2 group, a substituted or unsubstituted phenyl group, an indolin-3-yl group or a 5-hydroxyindolin-3-yl group, andQ represents an optionally substituted aromatic ring or an optionally substituted heterocycle containing 1 or 2 nitrogen atoms.Drugs having an antiallergic action.
Type:
Grant
Filed:
May 23, 1985
Date of Patent:
November 4, 1986
Assignee:
Panmedica
Inventors:
Claude Laruelle, Marcel Lepant, Bernard Raynier
Abstract: The present invention relates to new dipeptides of L-5-hydroxytryptophan.They correspond to the general formula below: ##STR1## in which: X represents hydrogen or a lower acyl radical andQ represents a free or esterified aminoacid radical.Application: drugs for combating disorder of the serotoninergic system.
Type:
Grant
Filed:
May 18, 1984
Date of Patent:
May 21, 1985
Assignee:
S.A. Panmedica
Inventors:
Claude Laruelle, Marcel Lepant, Bernard Raynier
Abstract: A pharmaceutical composition suitable for increasing cerebral serotonin concentration, comprising a serotonin precursor selected from the group consisting of 5-hydroxytryptophan and derivatives of 5-hydroxytryptophan having the formula: ##STR1## wherein R represent hydrogen; a C.sub.1 -C.sub.12 alkyl group; or a C.sub.5 -C.sub.16 alicyclic, monocyclic aromatic hydrocarbyl, or polycyclic aromatic hydrocarbyl group; and a nitrogenous heterocyclic compound selected from the group consisting of inosine, theophylline, theobromine, allopurinol, pyridoxine, hypoxanthine, folic acid, adenine, nicotinamide, caffeine, and orotic acid.
Abstract: Derivatives of 2-[3-(3-indolyl 2-amino propionyloxy] acetic acid corresponding to the following general formula I: ##STR1## in which R represents a hydrogen atom, a linear or branched alkyl radical including 1 to 12 carbon atoms, or a mono-alicyclic or polycyclic radical containing 5 to 16 carbon atoms, possibly linked by a methylene radical, and their pharmaceutically acceptable addition salts, are useful as medicaments for palliating deficiency of the serotoninergic system.
Abstract: The present invention relates to novel soluble N.sub.2 substituted derivatives of 2,4-diamino 5-benzyl pyrimidines. These derivatives correspond to the general formula III below: ##STR1## The novel soluble N.sub.2 substituted derivatives are powerful antibacterial agents.