Abstract: A vaccine preparation comprising an antigen for use in the prophylactic or therapeutic treatment of a subject by intradermal administration through laser-generated micropores, wherein the antigen is linked to a binder of a dermal migratory antigen-presenting cell (APC); and a pharmaceutical preparation comprising an active substance for use in the prophylactic or therapeutic treatment of a subject by intradermal administration through laser-generated micropores, for regional delivery to a target location. The invention further relates to the laser-assisted intradermal administration of antigens accompanied by repeated chemotherapy.

Abstract: A vaccine preparation comprising an antigen for use in the prophylactic or therapeutic treatment of a subject by intradermal administration through laser-generated micropores, wherein the antigen is linked to a binder of a dermal migratory antigen-presenting cell (APC); and a pharmaceutical preparation comprising an active substance for use in the prophylactic or therapeutic treatment of a subject by intradermal administration through laser-generated micropores, for regional delivery to a target location. The invention further relates to the laser-assisted intradermal administration of antigens accompanied by repeated chemotherapy.

Abstract: A monolithic, side pumped solid-state laser (1) comprising a laser resonator structure (3) comprised of a laser gain medium (2) having a longitudinal axis (L), wherein the laser resonator structure (3) comprises end faces (4) forming a linear optical path resonant cavity there between, at least one of the end faces (4) comprising at least partially reflecting laser mirrors (4a, 4b) in particular deposited thereon, the laser gain medium (2) comprising a side face (2a) for receiving pump light (5a) of a pump source (5), wherein the pump light (5a) is generated by a diode laser (5), and comprising a conductive cooler (6) comprising contact faces (6c) contacting the laser gain medium (2), and comprising a reflector (7) arranged opposite to the side face (2a) with respect to the longitudinal axis (L), wherein the laser gain medium (2) is a low gain material.

Abstract: The laser micro-porator (10) for porating a biological membrane (1), comprises: a) a laser source (7) that emits a pulsed beam (4), the laser source (7) comprising a laser diode (7c); b) optics (8a,8b,8x) that modify the pulsed beam to direct a laser beam (4) of less that 1 mm width on the biological membrane (1); c) a deflector (8f) oriented to direct the laser beam (4) in various directions; d) a laser beam shaping device that reshapes the energy intensity distribution of the laser beam (4); and e) a poration controller (11) that controls the laser source (7) to create a poration consisting of a plurality of individual pores (2) in the biological membrane (1).

Abstract: The invention relates to a skin contact detecting device (1) for a device (24) to be secured, comprising a contact piece (2) with a bearing surface (3) and comprising a safety circuit (7) with a light source (6), a photodetector (9), and an analyzing circuit (17). The bearing surface (3) has a light outlet portion (4) and a light inlet portion (5) which is delimited by the light outlet portion. Furthermore, the light source (6) has a main beam direction (8) of the emitted electromagnetic radiation, said main beam direction being oriented in the direction of the light outlet portion (4). The photodetector (9) has a detecting region (10) for electromagnetic radiation, said detecting region being oriented in the direction of the light inlet portion (5). The light source (6) is designed to emit light of a first (13) and at least one second (14) wavelength, and the photodetector (9) is sensitive to the first (13) and the second (14) wavelength.

Abstract: A laser device (10) for ablating a biological tissue (1), comprising: a) a laser source (7) that is configured to emit a laser beam (4); b) optics (8a, 8b, 8x) configured to modify the laser beam (4) such as to direct the laser beam (4) on the biological tissue (1); d) a controller (11) that is configured to control the laser source (7) to emit the laser beam (4) to create an ablation in biological tissue (1), whereby e) a sensor (19) being configured to receive back scattered light from the biological tissue (1); f) a tissue controller (18) that is operationally coupled to the sensor (19) to receive a sensor signal (Ri) of the sensor (19); and g) the tissue controller (18) being configured to compare a series of at least two consecutive sensor signals (R1, R2, R3, . . . ) and being configured to generate a tissue control signal (TCS) when the value of the series of consecutive sensor signals (R1, R2, R3, . . . ) decreases in a predetermined amount.

Abstract: The transdermal delivery system for treating infertility in a patient comprises an apparatus (10) for facilitating transdermal delivery of a drug (5a) through an area of the apparatus (10) comprises an ablator that is configured to generate a microporation in the area of the skin of the patient, and comprises a drug (5a), wherein the drug effects at least one of the biological regulation of at least one oocyte containing follicle, stimulation of follicle growth, induction of ovulation, promotion of gestational status, maintenance of conceptus, maintenance of pregnancy.

Abstract: A monolithic, side pumped solid-state laser (1) comprising a laser resonator structure (3) comprised of a laser gain medium (2) having a longitudinal axis (L), wherein the laser resonator structure (3) comprises end faces (4) forming a linear optical path resonant cavity there between, at least one of the end faces (4) comprising at least partially reflecting laser mirrors (4a, 4b) in particular deposited thereon, the laser gain medium (2) comprising a side face (2a) for receiving pump light (5a) of a pump source (5), wherein the pump light (5a) is generated by a diode laser (5), and comprising a conductive cooler (6) comprising contact faces (6c) contacting the laser gain medium (2), and comprising a reflector (7) arranged opposite to the side face (2a) with respect to the longitudinal axis (L), wherein the laser gain medium (2) is a low gain material.

Abstract: The deflection apparatus (1) for the deflection of electromagnetic radiation, in particular of a laser beam, includes a drive apparatus (2) and includes a beam deflection apparatus (4), in particular a mirror (4), which is arranged with the drive device (2) such that the drive apparatus (2) determines the alignment of the beam deflection apparatus (4), and includes a friction apparatus (5) which is arranged and made such that it brings about static friction or sliding friction onto the movably journaled beam deflection apparatus (4), with the drive apparatus (2) being made such that it can generate a drive force which overcomes the static friction, and includes a control apparatus (10) for the control of the drive apparatus (2). (FIG.

Abstract: A laser device (10) for ablating a biological tissue (1), comprising: a) a laser source (7) that is configured to emit a laser beam (4); b) optics (8a, 8b, 8x) configured to modify the laser beam (4) such as to direct the laser beam (4) on the biological tissue (1); d) a controller (11) that is configured to control the laser source (7) to emit the laser beam (4) to create an ablation in biological tissue (1), whereby e) a sensor (19) being configured to receive back scattered light from the biological tissue (1); f) a tissue controller (18) that is operationally coupled to the sensor (19) to receive a sensor signal (Ri) of the sensor (19); and g) the tissue controller (18) being configured to compare a series of at least two consecutive sensor signals (R1,R2, R3, . . . ) and being configured to generate a tissue control signal (TCS) when the value of the series of consecutive sensor signals (R1, R2, R3, . . . ) decreases in a predetermined amount.

Abstract: A micro-porator (10) for porating a biological membrane (1), comprising: a) a controller (11) b) an initial microporation dataset (D); c) and an ablator (10a) for creating a microporation on the biological membrane (1), the controller (11) controlling the ablator (10a) based on the initial microporation dataset (D), to create the microporation as defined by the initial microporation dataset (D).

Abstract: A tip (8) comprising a first portion (8r) that is configured to be removably coupled to a laser porator (10) and a second portion (8h) defining an aperture (8x) and comprising a tissue biasing element (8a) that is configured to deform at least a portion (1a) of a tissue (1) that is subject to a laser treatment.

Abstract: Use of an immunomodulatory, immunostimulatory, or immunosuppressive drug in the manufacture of a medicament for treatment of a skin related disease or disorder, wherein the drug is formulated for topical administration to porated skin having a plurality of pores with predetermined geometry such that the concentration of the drug in combination with the predetermined geometry of the pores are effective in treatment of the skin related disease or disorder.

Abstract: A system for transmembrane administration of a permeant, the system comprising: a) at least one permeant (5a), b) data of at least one initial microporation dataset (D) for the at least one permeant (5a), c) and a micro-porator (10) configured to porate a biological membrane (1) as defined by the initial microporation dataset (D).

Abstract: There is disclosed a method for creating an initial permeation surface (A) in a biological membrane (1) comprising: a) creating a plurality of individual micropores (2i) in the biological membrane (1), each individual micropore (2i) having an individual permeation surface (Ai); and b) creating such a number of individual micropores (2i) and of such shapes, that the initial permeation surface (A), which is the sum of the individual permeation surfaces (Ai) of all individual micropores (2i), having a desired value. A Microporator performing the method is also disclosed.

Abstract: The transdermal delivery system for treating infertility in a patient comprises an apparatus (10) for facilitating transdermal delivery of a drug (5a) through an area of the apparatus (10) comprises an ablator that is configured to generate a microporation in the area of the skin of the patient, and comprises a drug (5a), wherein the drug effects at least one of the biological regulation of at least one oocyte containing follicle, stimulation of follicle growth, induction of ovulation, promotion of gestational status, maintenance of conceptus, maintenance of pregnancy.

Abstract: The laser micro-porator (10) for porating a biological membrane (1), comprises: a) a laser source (7) that emits a pulsed beam (4), the laser source (7) comprising a laser diode (7c); b) optics (8a,8b,8x) that modify the pulsed beam to direct a laser beam (4) of less that 1 mm width on the biological membrane (1); c) a deflector (8f) oriented to direct the laser beam (4) in various directions; d) a laser beam shaping device that reshapes the energy intensity distribution of the laser beam (4); and e) a poration controller (11) that controls the laser source (7) to create a poration consisting of a plurality of individual pores (2) in the biological membrane (1).