Patents Assigned to PanVera Corporation
  • Process for glucuronidation screening
    Patent number: 6319678
    Abstract: A process used to identify activity of conjugative enzymes involved in xenobiotic transformations, such as glucuronosyltransferases.
    Type: Grant
    Filed: June 25, 1999
    Date of Patent: November 20, 2001
    Assignee: PanVera Corporation
    Inventors: Olga Trubetskoy, Peter M. Shaw
  • Compositions for cytochrome P450 biotransformation reactions
    Patent number: 5891696
    Abstract: A storable biotransformation mixture that can oxidize a drug, comprising a cytochrome P450 enzyme, an electron donor; and, a buffer solution. In a preferred embodiment the mixture also contains liposomes, cytochrome b.sub.5 and NADPH-P450 reductase as the electron donor. The mixture is storable at a temperature less than 8.degree. C. to for at least two weeks and is able to oxidize a drug after storage.
    Type: Grant
    Filed: August 1, 1997
    Date of Patent: April 6, 1999
    Assignee: Panvera Corporation
    Inventors: Peter M. Shaw, Robert G. Lowery, David V. Thompson
  • Method for detecting and quantitating nucleic acid impurities in biochemical preparations
    Patent number: 5824557
    Abstract: A homogeneous fluorescence-based nucleic acid detection and quantitation system is provided to measure nucleic acid in protein solutions. The process relies on the intercalation of a non-fluorescent dye into a double-stranded nucleic acid helix or single-stranded nucleic acid. The dye fluoresces after intercalation and the intensity is a direct measurement of the amount of nucleic acid present in the sample.
    Type: Grant
    Filed: April 2, 1996
    Date of Patent: October 20, 1998
    Assignee: PanVera Corporation
    Inventors: Thomas J. Burke, Randall E. Bolger, Francis J. Lenoch
  • Method and kit for detecting nucleic acid cleavage utilizing a covalently attached fluorescent tag
    Patent number: 5786139
    Abstract: The present invention is based on the degradation of a fluorescence labeled nucleic acid such as DNA (F-DNA), RNA (F-RNA) or DNA/RNA substrate. The label may be covalently attached to the relatively high volume substrate at one position or many positions. The nucleic acid is then put in contact with another substance and activity is detected by Fluorescence Polarization.
    Type: Grant
    Filed: December 9, 1994
    Date of Patent: July 28, 1998
    Assignee: PanVera Corporation
    Inventors: Thomas J. Burke, Randall E. Bolger, William J. Checovich, David V. Thompson