Patents Assigned to PAQ Therapeutics Inc.
  • KRAS G12D Proteolysis Targeting Chimeras
    Publication number: 20250051364
    Abstract: Provided herein are KRAS G12D proteolysis targeting chimeras (PROTACs), compositions comprising the KRAS G12D PROTACs, and methods of making and using the KRAS G12D PROTACs, e.g., to promote degradation of KRAS G12D and/or treat KRAS G12D-associated cancers. In an embodiment, the KRAS G12D PROTAC has the following structural formula: [KRAS G12Di]-L?-[Degron], or a pharmaceutically acceptable salt thereof, wherein values for the variables (e.g., KRAS G12Di, L?, Degron) are as described herein.
    Type: Application
    Filed: August 29, 2024
    Publication date: February 13, 2025
    Applicant: PAQ Therapeutics Inc.
    Inventors: Nan Ji, Ning Yin, Hui Qiu
  • KRAS G12D Proteolysis Targeting Chimeras
    Publication number: 20240247000
    Abstract: Provided herein are KRAS G12D proteolysis targeting chimeras (PROTACs), compositions comprising the KRAS G12D PROTACs, and methods of making and using the KRAS G12D PROTACs, e.g., to promote degradation of KRAS G12D and/or treat KRAS G12D-associated cancers. In an embodiment, the KRAS G12D PROTAC has the following structural formula: [KRAS G12Di]-L?-[Degron], or a pharmaceutically acceptable salt thereof, wherein values for the variables (e.g., KRAS G12Di, L?, Degron) are as described herein.
    Type: Application
    Filed: February 8, 2024
    Publication date: July 25, 2024
    Applicant: PAQ Therapeutics Inc.
    Inventors: Nan Ji, Ning Yin, Hui Qiu