Abstract: Systems and methods for manufacturing and processing microwires for use as microelectrodes are disclosed. The disclosed techniques provide methods for creating microelectrode bundles with different organizations and patterns. Systems and methods of the present disclosure also provide methods for electrochemically modifying bundles of microelectrode ends.
Type:
Grant
Filed:
September 26, 2019
Date of Patent:
August 2, 2022
Assignees:
PARADROMICS, INC., THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
Inventors:
Yifan Kong, Matthew R. Angle, Mina-Elraheb Hanna, Abdulmalik Obaid, Nicholas Melosh
Abstract: A system for monitoring neural activity of a living subject is provided. The system may comprise a correspondence module configured to be in communication with (1) a neural module and (2) one or more additional modules comprising a sensing module, another neural module, and/or a data storage module. The neural module(s) are configured to collect neural data indicative of perceptions experienced by the living subject. The sensing module may be configured to collect (1) sensor data indicative of real-world information about an environment around the living subject, and/or (2) sensor data indicative of a physical state or physiological state of the living subject. The data storage module may be configured to store prior neural data and/or prior sensor data.
Type:
Grant
Filed:
March 12, 2019
Date of Patent:
July 27, 2021
Assignee:
Paradromics, Inc.
Inventors:
Matthew Angle, Edmund Huber, Richard C. Gerkin, Konrad Kording
Abstract: Systems and methods for processing neural signals are provided. A neural data analysis system may comprise a feature extraction module configured to extract a plurality of features from neural signal waveforms obtained by an implanted neural interface probe with a plurality of channels or electrodes, and transmit the extracted features as a plurality of discrete outputs. The neural data analysis system may also comprise a feature-event coalescence module configured to receive the plurality of discrete outputs from the feature extraction module, and construct a model-based inference of bioelectric activity based on feature event statistics, prior knowledge of bioelectric signals, and/or a behavioral model of the feature extraction module.
Type:
Grant
Filed:
February 13, 2019
Date of Patent:
May 19, 2020
Assignee:
PARADROMICS, INC.
Inventors:
Matthew Angle, Edmund Huber, Robert Edgington
Abstract: A system and method for testing the quality of a conductor is disclosed. Specifically, a system of testing a conductor using voltage source generator that is capacitively-coupled through the conductor to voltage detector is disclosed. The voltage source generates a varying voltage signal which induces a voltage signal in the capacitively coupled microwire conductor. The voltage detector that is also capacitively-coupled to the conductor measures the induced voltage. Using the detected voltage signal, the voltage detector determines whether there are any conductive breaks in the conductor.
Type:
Grant
Filed:
August 12, 2016
Date of Patent:
February 18, 2020
Assignee:
PARADROMICS, INC.
Inventors:
Matthew Angle, Yifan Kong, Edmund Huber
Abstract: A neural-interface probe is provided. The probe may comprise a chip, a wire bundle substrate, and an encapsulant material. The chip may comprise a plurality of bond pads. The wire bundle substrate may comprise a plurality of wires extending through the substrate. The plurality of wires may comprise: (1) a proximal portion connected to the plurality of bond pads to thereby couple the chip to the substrate, and (2) a flexible distal portion configured to interface with neural matter. The encapsulant material may be disposed at least between the chip and the wire bundle substrate.
Abstract: A system and method for creating desired splay patterned microelectrodes is disclosed. A bundle of microwires is arranged into a desired splay pattern. This may be performed mechanically with a rigid frame, electronically by charging the microwires, or with some other technique. The microwires in the desired splay pattern are then heated to release internal tension. Upon completion of heating, the microwires are then slowly cooled such that the splayed microwires will retain the desired splay pattern. Insulation may then be added to the microwires if the microwires are not already insulated.
Type:
Application
Filed:
September 29, 2016
Publication date:
March 29, 2018
Applicant:
Paradromics Inc.
Inventors:
Matthew Angle, Yifan Kong, Edmund Huber