Abstract: Various devices and methods for guiding a biopsy surgical tool are disclosed. One type of surgical device includes a first rotational mechanism, a translational mechanism, and a second rotational mechanism. In some cases, the second rotational mechanism includes a circular frame and an end-effector. The yaw movement of the end-effector is effectuated via the first rotational mechanism. In addition, roll and pitch movements of the end-effector are effectuated via the second rotational mechanism. Furthermore, translational movement of the end-effector is effectuated via the translational mechanism.