Abstract: A tool for planning and management of clinical trials. The tool computes a patient enrollment timeline in a clinical trial using multiple factors that bear on the rate of patient enrollment. The factors may be site-dependent factors or may be country-dependent factors. When these factors are applied, different sites may have different rates of enrollment in the same interval. Further, the factors may be time dependent such that even the same sites may have different enrollment rates in different intervals. Once the timeline is created, the tool may use it to calculate a schedule of monitor visits, project trial completion or otherwise generate output used in management of the clinical trial.

Abstract: A tool for planning and management of clinical trials. The tool computes a patient enrollment timeline in a clinical trial using multiple factors that bear on the rate of patient enrollment. The factors may be site-dependent factors or may be country-dependent factors. When these factors are applied, different sites may have different rates of enrollment in the same interval. Further, the factors may be time dependent such that even the same sites may have different enrollment rates in different intervals. Once the timeline is created, the tool may use it to calculate a schedule of monitor visits, project trial completion or otherwise generate output used in management of the clinical trial.

Abstract: A computer-based system configured to present a user interface that enables a user to access multiple clinical trial systems via a common secure web-based interface. Data integration and reconciliation achieved using an integration platform, in which multiple clinical trial systems are connected to a central messaging hub, provides an integrated clinical trial workflow system that reduces the redundancy in data entry and functionality present in conventional clinical trial workflow systems that employ standalone systems for various aspects of clinical trial management. Aggregation of data using the integration platform provides clinical trial directors with consolidated useful information for making management decisions and the user interface may be dynamically configured based, at least in part, on user access credentials resulting in a more efficient workflow for administrators of a clinical trial.

Abstract: A computer-based system configured to present a user interface that enables a user to access multiple clinical trial systems via a common secure web-based interface. Data integration and reconciliation achieved using an integration platform, in which multiple clinical trial systems are connected to a central messaging hub, provides an integrated clinical trial workflow system that reduces the redundancy in data entry and functionality present in conventional clinical trial workflow systems that employ standalone systems for various aspects of clinical trial management. Aggregation of data using the integration platform provides clinical trial directors with consolidated useful information for making management decisions and the user interface may be dynamically configured based, at least in part, on user access credentials resulting in a more efficient workflow for administrators of a clinical trial.

Abstract: A decision support tool for development of drugs targeting central nervous system conditions. The tool receives measurements made on subjects, which are converted to model outputs using neurocircuitry models. The models are used by a computing device to generate neuro-circuitry based signatures. Neuro-circuitry based signatures associated with an investigational compound may be compared to reference neuro-circuitry based signatures to identify parameters of a clinical trial protocol. The neuro-circuitry based signature comparisons, when generated based on measurement data collected in early phases of a clinical trial process, may increase the likelihood that the investigational compound will quickly and cost-effectively emerge from clinical trials with proof that the investigational compound is effective for treating one or more CNS conditions.

Abstract: A technique for reliably measuring brain atrophy based on image data, such as data collected as part of an MRI scan of a subject's brain. Rather than measure anatomical features of the brain in one of the scan planes as output by an MRI system, the image data is reformatted to generate a slice that may be transverse to those scan planes. The transverse slice is generated by determining a location of anatomical landmarks and reformatting the image data to represent a slice through these anatomical landmarks. The Anterior and Posterior Commissures are useful landmarks and ventricle area is a useful characteristic to measure from the slice. The rate of change of this measured characteristic can be tracked to determine disease progression and may be useful for diagnosis or evaluation of treatments, and the technique may be applied during clinical trials.

Abstract: Methods and apparatus for facilitating monitoring in a clinical trial. The method includes acts of receiving data from at least one information technology system configured to process clinical trial data, and assigning a site prioritization to each of a plurality of sites for at least one clinical trial associated with the at least one information technology system. Assigning a site prioritization is based, at least in part, on the received data. The method further includes an act of outputting an indication of the site prioritization.

Abstract: A tool for planning and management of clinical trials. The tool computes a patient enrollment timeline in a clinical trial using multiple factors that bear on the rate of patient enrollment. The factors may be site-dependent factors or may be country-dependent factors. When these factors are applied, different sites may have different rates of enrollment in the same interval. Further, the factors may be time dependent such that even the same sites may have different enrollment rates in different intervals. Once the timeline is created, the tool may use it to calculate a schedule of monitor visits, project trial completion or otherwise generate output used in management of the clinical trial.

Abstract: A computer-based system configured to present a user interface that enables a user to access multiple clinical trial systems via a common secure web-based interface. Data integration and reconciliation achieved using an integration platform, in which multiple clinical trial systems are connected to a central messaging hub, provides an integrated clinical trial workflow system that reduces the redundancy in data entry and functionality present in conventional clinical trial workflow systems that employ standalone systems for various aspects of clinical trial management. Aggregation of data using the integration platform provides clinical trial directors with consolidated useful information for making management decisions and the user interface may be dynamically configured based, at least in part, on user access credentials resulting in a more efficient workflow for administrators of a clinical trial.