Abstract: A pharmaceutical tablet dispensing and packaging system comprising a packaging unit, a first dispensing unit above the packaging unit and defined by a front portion, a rear portion and side portions where tablet cassettes containing tablets are installed in the dispensing unit detachably through the front portion and aligned in columns to selectively release the tablets through the rear portion into the tablet packaging unit, a second dispensing unit mirrored and hinged to the first dispensing unit to form spatial shafts by corresponding grooves of the dispensing units, and a hopper disposed beneath the dispensing units into the tablet packaging unit. Vertical dividers are formed on the rear portion to incorporate the vertical grooves between and by the dividers and each rear side of the tablet cassettes.