Patents Assigned to Parkinson's Institute
  • Compositions and methods for treatment of symptoms in parkinson's disease patients
    Patent number: 10653686
    Abstract: The invention provides dosage forms and methods utilizing nicotine to treat symptoms of a neurologic disorder. In some embodiments, the invention provides compositions for treatment of gait and balance problems associated with Parkinson's Disease.
    Type: Grant
    Filed: July 25, 2017
    Date of Patent: May 19, 2020
    Assignee: PARKINSON'S INSTITUTE
    Inventor: Arasteh Ari Azhir
  • Diagnosis of neurodegenerative disorders
    Patent number: 10631772
    Abstract: Methods are provided for non-invasive early screening of a subject for a neurodegenerative disorder, by analyzing one or more parameters associated with the neurodegenerative disorder.
    Type: Grant
    Filed: March 6, 2017
    Date of Patent: April 28, 2020
    Assignee: PARKINSON'S INSTITUTE
    Inventors: J. William Langston, Ruksana Azhu Valappil
  • Pluripotent cell lines and methods of use thereof
    Patent number: 10233422
    Abstract: Methods of generating cell lines with a sequence variation or copy number variation of a gene of interest, methods of use thereof, and cell lines with a sequence variation or copy number variation of a gene of interest are provided.
    Type: Grant
    Filed: August 31, 2016
    Date of Patent: March 19, 2019
    Assignees: PARKINSON'S INSTITUTE, THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
    Inventors: Renee Ann Reijo Pera, J. William Langston, Birgitt Schule, Theodore D. Palmer, Blake Byers, Ha Nam Nguyen, James Anthony Byrne, Branden John Cord
  • Diagnosis of neurodegenerative disorders
    Patent number: 9622669
    Abstract: Methods are provided for non-invasive early screening of a subject for a neurodegenerative disorder, by analyzing one or more parameters associated with the neurodegenerative disorder.
    Type: Grant
    Filed: June 15, 2009
    Date of Patent: April 18, 2017
    Assignee: PARKINSON'S INSTITUTE
    Inventors: J. William Langston, Ruksana Azhu Valappil
  • Pluripotent cell lines and methods of use thereof
    Patent number: 9464273
    Abstract: Methods of generating cell lines with a sequence variation or copy number variation of a gene of interest, methods of use thereof, and cell lines with a sequence variation or copy number variation of a gene of interest are provided.
    Type: Grant
    Filed: December 6, 2013
    Date of Patent: October 11, 2016
    Assignees: PARKINSON'S INSTITUTE, THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
    Inventors: Renee Ann Reijo Pera, J. William Langston, Birgitt Schule, Theodore D. Palmer, Blake Byers, Ha Nam Nguyen, James Anthony Byrne, Branden John Cord
  • Assay to determine LRRK2 activity in parkinson's disease
    Patent number: 9417239
    Abstract: Disclosed are novel phosphorylation sites identified in LRRK2 and associated with Parkinson's Disease, antibodies that specifically bind to the novel phosphorylation sites, and laboratory and clinical uses thereof.
    Type: Grant
    Filed: September 29, 2015
    Date of Patent: August 16, 2016
    Assignee: PARKINSON'S INSTITUTE
    Inventors: Jeremy Nichols, Birgitt Schüle
  • Assay to determine LRRK2 activity in parkinson's disease
    Patent number: 9187567
    Abstract: Disclosed are novel phosphorylation sites identified in LRRK2 and associated with Parkinson's Disease, antibodies that specifically bind to the novel phosphorylation sites, and laboratory and clinical uses thereof.
    Type: Grant
    Filed: May 18, 2012
    Date of Patent: November 17, 2015
    Assignee: PARKINSON'S INSTITUTE
    Inventors: Jeremy Nichols, Birgitt Schüle
  • PLURIPOTENT CELL LINES AND METHODS OF USE THEREOF
    Publication number: 20140356455
    Abstract: Methods of generating cell lines with a sequence variation or copy number variation of a gene of interest, methods of use thereof, and cell lines with a sequence variation or copy number variation of a gene of interest are provided.
    Type: Application
    Filed: December 6, 2013
    Publication date: December 4, 2014
    Applicants: The Board of Trustees of the Leland Stanford Junior University, Parkinson's Institute
    Inventors: Renee Ann Reijo Pera, J. William Langston, Birgitt Schule, Theodore D. Palmer, Blake Byers, Ha Nam Nguyen, James Anthony Byrne, Branden John Cord
  • Pluripotent cell lines and methods of use thereof
    Patent number: 8669048
    Abstract: Methods of generating cell lines with a sequence variation or copy number variation of a gene of interest, methods of use thereof, and cell lines with a sequence variation or copy number variation of a gene of interest are provided.
    Type: Grant
    Filed: June 24, 2009
    Date of Patent: March 11, 2014
    Assignee: Parkinson's Institute
    Inventors: Renee Ann Reijo Pera, J. William Langston, Birgitt Schüle, Theodore D. Palmer
  • Compositions and Methods for Treatment of Symptoms in Parkinson's Disease Patients
    Publication number: 20130017259
    Abstract: The invention provides dosage forms and methods utilizing nicotine to treat symptoms of a neurologic disorder. In some embodiments, the invention provides compositions for treatment of gait and balance problems associated with Parkinson's Disease.
    Type: Application
    Filed: July 3, 2012
    Publication date: January 17, 2013
    Applicant: The Parkinson's Institute
    Inventor: Arasteh Ari Azhir
  • METHODS AND COMPOSITIONS FOR TREATMENT OF NEUROLOGICAL DISORDERS
    Publication number: 20110111014
    Abstract: Methods and compositions are provided for preventing and treating neurological disorders, in particular Parkinson's disease.
    Type: Application
    Filed: June 26, 2008
    Publication date: May 12, 2011
    Applicant: Parkinson's Institute
    Inventor: William J. Langston
  • Pluripotent cell lines and methods of use thereof
    Publication number: 20100167286
    Abstract: Methods of generating cell lines with a sequence variation or copy number variation of a gene of interest, methods of use thereof, and cell lines with a sequence variation or copy number variation of a gene of interest are provided.
    Type: Application
    Filed: June 24, 2009
    Publication date: July 1, 2010
    Applicants: Parkinson's Institute, The Board of Trustees of the Leland Stanford Junior University
    Inventors: Renee Ann Reijo Pera, J. William Langston, Birgitt Schüle, Theodore D. Palmer, Blake Byers, Ha Nam Nguyen, James Anthony Byrne, Brandon John Cord
  • Methods and compositions for reduction of side effects of therapeutic treatments
    Patent number: 7718677
    Abstract: The invention provides compositions and methods utilizing a nicotinic receptor modulator, e.g., to reduce or eliminate a side effect associated with dopaminergic agent treatment. In some embodiments, the invention provides compositions and methods utilizing a combination of a dopaminergic agent and a nicotinic receptor modulator that reduces or eliminates a side effect associated with dopaminergic agent treatment.
    Type: Grant
    Filed: April 2, 2008
    Date of Patent: May 18, 2010
    Assignee: Parkinson's Institute
    Inventors: Maryka Quik, Donato Di Monte, J. William Langston
  • Methods and systems for identifying compounds that modulate alpha-synuclein aggregation
    Publication number: 20070214509
    Abstract: This invention relates to the field of chemical sensing and signal transduction using devices that are sensitive to single molecular species or closely related families of species. In one aspect, the present invention relates to systems that are designed to detect target molecules in the gas phase, as well as more condensed phases, in the presence of heterogeneous populations of molecular species.
    Type: Application
    Filed: December 22, 2006
    Publication date: September 13, 2007
    Applicant: The Parkinson's Institute
    Inventor: J. Langston