Patents Assigned to PARTICLE METRIX GMBH
  • Publication number: 20220341917
    Abstract: The invention relates to a method for determining the florescence of antibodies on exosomes using quality control of the measurement using two different control methods.
    Type: Application
    Filed: April 27, 2020
    Publication date: October 27, 2022
    Applicant: PARTICLE METRIX GMBH
    Inventor: Hanno WACHERNIG
  • Publication number: 20220236188
    Abstract: The invention relates to a device and method for reducing the reduction in intensity of a fluorescence dye by laser light when determining fluorescence and the number of antibodies on exosomes, comprising means for storing different measurement points of various differently coloured lasers in a measuring cell at certain measurement positions, the focusing of the laser beam interacting with the sample being recorded in a video camera as the centre of a convergent beam bundle.
    Type: Application
    Filed: July 6, 2020
    Publication date: July 28, 2022
    Applicant: PARTICLE METRIX GMBH
    Inventors: Hanno WACHERNIG, Clemens HELMBRECHT, Jens SCHIFFMANN
  • Patent number: 10928290
    Abstract: The invention relates to a device and method for measuring the concentration, size and zeta potential of nanoparticles in liquids in scattered light mode and fluorescence mode, comprising the following features: a) a sample (28) is irradiated from above by a laser (1) via a beamsplitter (14) and an adjustable-focus liquid lens (9), and the reflected beam of light is deflected by the same beamsplitter (14) and a further liquid lens (8) onto a detector (5), and analysed; b) to observe the fluorescent light, a fluorescence filter (19) is connected in the convergent beam path between the liquid lens (8) and the detector (5), to increase the distance between the scattered light plane (31) and the fluorescence plane (30); and c) to control the measurement process, a particle tracking program, an optical control unit (15) and a display (2) with a touch screen are used.
    Type: Grant
    Filed: November 3, 2017
    Date of Patent: February 23, 2021
    Assignee: PARTICLE METRIX GMBH
    Inventors: Hanno Wachernig, Margret Boeck
  • Publication number: 20190277743
    Abstract: The invention relates to a device and method for measuring the concentration, size and zeta potential of nanoparticles in liquids in scattered light mode and fluorescence mode, comprising the following features: a) a sample (28) is irradiated from above by a laser (1) via a beamsplitter (14) and an adjustable-focus liquid lens (9), and the reflected beam of light is deflected by the same beamsplitter (14) and a further liquid lens (8) onto a detector (5), and analysed; b) to observe the fluorescent light, a fluorescence filter (19) is connected in the convergent beam path between the liquid lens (8) and the detector (5), to increase the distance between the scattered light plane (31) and the fluorescence plane (30); and c) to control the measurement process, a particle tracking program, an optical control unit (15) and a display (2) with a touch screen are used.
    Type: Application
    Filed: November 3, 2017
    Publication date: September 12, 2019
    Applicant: PARTICLE METRIX GMBH
    Inventors: Hanno WACHERING, Margret BOECK
  • Patent number: 9939363
    Abstract: A method and device for optically detecting particles, including: (a) a cell wall of rectangular cross-section is fitted on a longitudinal surface and adjoining transverse surface with an L-shaped heating and cooling element; (b) the center of the transverse surface of the cell wall opposite the transverse surface which forms the support of the cell wall is irradiated by an irradiation device and is observed at right angles to the optical axis of the irradiation device; (c) the focus of the irradiation device and the observation device can be moved by a motor to any point in the three-dimensional inner region defined by the cell wall; (d) the surface of the cell wall opposite the optical glass window through which the radiation from the irradiation device enters comprises another optical glass window; (e) the temperature of the surface of the cell wall is monitored by two thermistors.
    Type: Grant
    Filed: May 12, 2015
    Date of Patent: April 10, 2018
    Assignee: PARTICLE METRIX GMBH
    Inventors: Hanno Wachemig, Margret Boeck
  • Publication number: 20170059471
    Abstract: A method and device for optically detecting particles (23) have the following features: (a) a cell wall (9) of rectangular cross-section, made of black glass, is fitted on a longitudinal surface and adjoining transverse surface with an L-shaped heating and cooling element (1); (b) the centre of the transverse surface of the cell wall (9) opposite the transverse surface which forms the support of the cell wall (9) is irradiated by an irradiation device and is observed at right angles to the optical axis of the irradiation device by means of an observation device; (c) the focus of the irradiation device and the focus of the observation device can be moved by a motor to any point in the three-dimensional inner region defined by the cell wall (9) by means of a control device; (d) the surface of the cell wall (9) opposite the optical glass window (11) through which the radiation from the irradiation device enters comprises another optical glass window (11) in the centre thereof; (e) the temperature of the surface
    Type: Application
    Filed: May 12, 2015
    Publication date: March 2, 2017
    Applicant: PARTICLE METRIX GMBH
    Inventors: Hanno WACHEMIG, Margaret BOECK