Abstract: A transdermal delivery system for delivery of a triptan into a tissue membrane of a subject. The system includes a transdermal microporation apparatus for heating a skin surface and a triptan drug delivery patch. The drug delivery patch comprises a top layer comprising an adhesive, a middle layer comprising the triptan, and a bottom layer. A method for treating a subject comprises identifying a subject having a migraine, using the transdermal microporation apparatus to open a plurality of micropores in the skin of the subject, and applying the triptan drug delivery patch to the subject's skin over the micropores for a period of time effective to deliver the triptan through the micropores in an amount effective to treat the subject's migraine.

Abstract: The device of the present invention comprises an intervening release liner as a common special feature, and the intervening release liner covers a part of an adhesive surface of a patch. The intervening release liner gets away from the patch, and is fixed to a patch application support (or porator tab). Due to such constitution, under a situation in use where the first part of the adhesive area of the patch adheres to a skin surface, the patch application support is slidable along the skin surface while peeling the intervening release liner from said part of the adhesive area of the patch to adhere to the skin surface.