Patents Assigned to Pasteur Mérieux Sérums et Vaccins S.A.
  • IgA1 protease fragment as carrier peptides
    Patent number: 7235242
    Abstract: The present invention is concerned with a fragment of IgA1-protease having 40 to 200 amino acid residues and comprising at least 40 amino acids of an amino acid sequence as shown in SEQ ID NO:1, beginning with the amino acid in any one of positions 1 to 5 and ending with an amino acid in any one of positions 40 to 104 or a homologous sequence, its use as a carrier for a conjugate, particularly in combination with a polysaccharide, and a process for producing the peptide as well as vaccines comprising said peptide.
    Type: Grant
    Filed: May 7, 2004
    Date of Patent: June 26, 2007
    Assignees: Max-Planck-Gesellschaft zur Forderung der Wissenschaften E.V., Pasteur Mérieux Sérums et Vaccins S.A.
    Inventors: Mark Achtman, Monique Moreau
  • IgA1 protease fragment as carrier peptides
    Publication number: 20040203108
    Abstract: The present invention is concerned with a fragment of IgA1-protease having 40 to 200 amino acid residues and comprising at least 40 amino acids of an amino acid sequence as shown in SEQ ID NO:1, beginning with the amino acid in any one of positions 1 to 5 and ending with an amino acid in any one of positions 40 to 104 or a homologous sequence, its use as a carrier for a conjugate, particularly in combination with a polysaccharide, and a process for producing the peptide as well as vaccines comprising said peptide.
    Type: Application
    Filed: May 7, 2004
    Publication date: October 14, 2004
    Applicants: Max-Planck-Gesellschaft zur Forderung Der Wissenschaffen E.V. Berlin, Pasteur Merieux Serums et Vaccins S.A.
    Inventors: Mark Achtman, Monique Moreau
  • Vaccine composition containing polyribosylribitol phosphate and method for making same
    Patent number: 6333036
    Abstract: Vaccine compositions are disclosed which comprise at least one antigen formed by the capsular polysaccharide of Haemophilus influenzae type b or high molecular weight polyribosylribitol phosphate coupled to tetanus anatoxin.
    Type: Grant
    Filed: December 30, 1997
    Date of Patent: December 25, 2001
    Assignee: Pasteur Merieux Serums, et Vaccins S.A.
    Inventors: Francois Arminjon, Jean-René Cartier
  • Macromolecular conjugates of hemoglobin, a procedure for their preparation and their uses
    Patent number: 5079337
    Abstract: The subject of the invention is a water-soluble macromolecular conjugate of hemoglobin characterized in that it is constitutedon the one hand, by hemoglobin,on the other, by a water-soluble polymer P containing polar groups, this macromolecular conjugate contains Z sites, bound to the polymer P and containing at least one negative charge carried for example by sulfate groups, the polymer P being bound to hemoglobinon the one hand, through the intermediary of at least one linkage established between at least one of the Z sites contained in the polymer and hemoglobin,and, on the other, through the intermediary of at least one covalent linkage established between the polymer and hemoglobin, or between at least one of the Z sites contained in the polymer and hemoglobin.The macromolecular conjugates according to the invention exhibit a lower affinity for oxygen than that of free hemoglobin.
    Type: Grant
    Filed: February 3, 1988
    Date of Patent: January 7, 1992
    Assignee: Pasteur Merieux Serums et Vaccins S.A.
    Inventors: Michele Leonard, Edith Dellacherie, Jean M. L. Neel, Claude Vigneron, Pierre Labrude