Abstract: The tripeptide Tyrosyl-seryl-valine is disclosed with its use as a pharmaceutical composition in treating a condition whose effects can be reduced by stimulating T-cell transformation and a cell proliferative disorder. A method is also disclosed making a pharmaceutical composition comprising providing the tripeptide Tyrosyl-seryl-valine and mixing said tripeptide with a pharmaceutical acceptable carrier.

Abstract: Thirty substantially pure and biologically active peptides are disclosed. Nucleic acids that have sequences coding for the biologically active peptides and pharmaceutical formulations produced thereform are also disclosed.

Abstract: The peptide Isoleucyl-valyl-threonyl-asparaginyl-threonyl-threonine (SEQ ID NO.1) is disclosed with its use as a pharmaceutical composition in reducing symptoms of viral disease and stimulating properties of immune system in a subject. A method is also disclosed for making a pharmaceutical composition comprising providing an Isoleucyl-valyl-threonyl-asparaginyl-threonyl-threonine (SEQ ID NO.1) peptide and mixing said peptide with a pharmaceutical acceptable carrier.

Abstract: A sealant cutting tool including a handle defining a blade slot. Also included is a clamping bolt having a clamp axis transverse the blade slot, which clamping bolt is threadably engaged with the handle. In addition, a “T” pull is operatively associated with the clamping bolt so that rotation of the “T” pull around the clamp axis causes a distal end of the clamping bolt to move relative to the blade slot. The sealant cutting tool may include a blade received in the blade slot in operative association with the clamping bolt. In addition, the “T” pull may include an engagement head operatively associated with a proximal end of the clamping bolt. The clamping bolt may include a noncylindrical shoulder received through a mating, noncircular opening formed in the engagement head. Thus, the noncircular opening may be selectively engaged with the noncylindrical shoulder, allowing the “T” pull to be selectively engaged or disengaged from the clamping bolt.

Abstract: A container (70) for constituting a formulation in liquid form, comprises an elongate outer body (71) split into a first section (72) and a second section (73), along the longitudinal axis thereof, The container (70) has an inner chamber (77) divided into a first compartment (78) and a second compartment (79) by a seal (80). Seal (80) is movable in use between a closed position, wherein the first compartment 78 and the second compartment are sealed thereby, to an open position, wherein the first compartment (78) and the second compartment (79) are unsealed and any contents therein are free to mix together in the inner chamber (77) to form the formulation. The seal (80) is movable from the closed position to the open position by rotation of the first section (72) relative to the second section (73), and the volume of the inner chamber (77) remains unchanged following unsealing. Once the seal (80) has been moved to the open position it is retained in that position.

Abstract: A knife blade having a cutting edge with a first end and a mounting edge opposite the cutting edge. Typically the first end will be a point, but other configurations are possible. In addition, the knife blade has a first attachment slot extending from the mounting edge toward the cutting edge and away from the first end. The first attachment slot may be tapered at a select taper angle. In addition, the first attachment slot may include a first segment extending from the mounting edge toward the cutting edge and a second segment extending from the first segment away from the first end. Similarly, a third segment of the first attachment slot may extend from the first segment toward the first end. In one embodiment, the first, second, and third segments form a substantially “T” shaped attachment slot. Preferably, the second and third segments of a “T” shaped attachment slot are tapered at a select taper angle from the junction with the first segment.

Abstract: A knife blade having a cutting edge with a first end and a mounting edge opposite the cutting edge. Typically the first end will be a point, but other configurations are possible. In addition, the knife blade has a first attachment slot extending from the mounting edge toward the cutting edge and away from the first end. The first attachment slot may be tapered at a select taper angle. In addition, the first attachment slot may include a first segment extending from the mounting edge toward the cutting edge and a second segment extending from the first segment away from the first end. Similarly, a third segment of the first attachment slot may extend from the first segment toward the first end. In one embodiment, the first, second, and third segments form a substantially “T” shaped attachment slot. Preferably, the second and third segments of a “T” shaped attachment slot are tapered at a select taper angle from the junction with the first segment.

Abstract: A sealant cutting tool including a handle defining a blade slot. Also included is a clamping bolt having a clamp axis transverse the blade slot, which clamping bolt is threadably engaged with the handle. In addition, a “T” pull is operatively associated with the clamping bolt so that rotation of the “T” pull around the clamp axis causes a distal end of the clamping bolt to move relative to the blade slot. The sealant cutting tool may include a blade received in the blade slot in operative association with the clamping bolt. In addition, the “T” pull may include an engagement head operatively associated with a proximal end of the clamping bolt. The clamping bolt may include a noncylindrical shoulder received through a mating, noncircular opening formed in the engagement head. Thus, the noncircular opening may be selectively engaged with the noncylindrical shoulder, allowing the “T” pull to be selectively engaged or disengaged from the claimping bolt.

Abstract: A vehicle body front end preassembly and method of making a vehicle front end assembly is disclosed. The vehicle body front end preassembly includes a frame to which an integrated front end module formed by an injection molding process is secured. The integrated front end module extends transversely across the vehicle and is provided with a plurality of fastener receptacles that are integrally molded as part of the integrated front end module. A plurality of reinforcement ribs are integrally molded as part of the integrated front end module. Unpainted body panels are secured to some of the fastener receptacles. The frame, injection molded integrated front end module, and body panels are then hot dipped in an electro-coating bath. According to the method of the present invention, the integrated front end module is injection molded to include integrally molded fastener receptacle and integrally molded reinforcement ribs that are injection molded from a fiber reinforced thermoplastic polymer.

Abstract: A method is provided for manufacturing a painted plastic component such as painted air bag covers, side cladding or exterior bumpers, which includes a painted film sheet and a one-piece thermoplastic elastomeric structural carrier. A bottom contact surface of the film sheet bonds with a front contact surface of the structural carrier by diffusion between the contact surfaces thereof within a mold cavity of an injection mold separate from the mold cavity of a vacuum mold which is utilized to vacuum-mold the film sheet to form the desired painted plastic component.

Abstract: A method and system for molding thermoplastic sandwich material to form a deep-drawn article utilizing a unique clamping technique and mechanism are described. The method includes the steps of positioning a blank of thermoplastic sandwich material having a cellular core over a female die having an article-defining cavity defined by inner surfaces of the female die. Then, an inner portion of the blank is forced into the female die along a substantially vertical axis and against the inner surfaces of the female die to obtain deep-drawn material. During the step of forcing at least one outer portion of the blank immediately adjacent the female die is clamped to guide the at least one outer portion of the blank to travel into the article-defining cavity at an acute angle with respect to the vertical axis. Thickness of at least one side wall of the deep-drawn material is substantially the same as thickness of the blank of thermoplastic sandwich material.

Abstract: The invention relates to reinforced composite inner roof panels of the sandwich-type having a cellular core. In a method for making a inner roof panel of the invention, a stack is formed that is made up of: an upper skin made of a reinforced thermoplastic material; a cellular core made of a thermoplastic material; and a bottom skin made of a reinforced thermoplastic material. The upper and lower skins and the cellular core are formed together and have regions of reduced thickness and regions of increased thickness that may provide head impact absorbing characteristics or form structural components of the passenger compartment. Examples of structural components that may be formed include HVAC ducts, wiring conduits, video display panel mounts or air bag receptacles.

Abstract: A molding method and a metal-covered plastic component such as partial or entire fascia, body side moldings, and the like, which have bright surface requirements and which includes a film sheet and a one-piece thermoplastic elastomeric structural carrier are provided. The film sheet includes a decorative layer of metal such as chrome. A plastic layer of the film sheet on which the layer of metal is formed is selected from a group consisting of polyester, polyurethane and polycarbonate. A bottom contact surface of the film sheet bonds with a front contact surface of the structural carrier by diffusion between the contact surfaces thereof within a mold cavity of an injection mold separate from the step of forming a preform which is securely positioned within the injection mold during injection molding to form the plastic part.

Abstract: A method is provided for manufacturing a painted plastic component having a badge, emblem or other ornamentation, such as air bag covers having a badge, or wherein the component is the badge itself. The method includes providing a painted film sheet and a one-piece thermoplastic elastomeric structural carrier. A bottom contact surface of the film sheet bonds with a front contact surface of the structural carrier by diffusion between the contact surfaces thereof within a mold cavity of an injection mold separate from the mold cavity of a vacuum mold which is utilized to vacuum-mold the film sheet to form the desired painted plastic component.

Abstract: The present invention involves a carbon fiber-filled sheet molding compound and method of manufacturing the same. The invention comprises providing chopped automotive carbon fibers, a predetermined resin paste, a first carrier film, and a second carrier film. The method further involves coating substantially completely one side of one of the first and second carrier films with the predetermined resin paste to define a coated side, depositing the chopped automotive carbon fibers onto the coated side, and covering the deposited carbon fibers with the second carrier film to define a compactible carbon-filled laminate. The method further includes compacting the carbon-filled laminate to admix the resin paste with the carbon fibers between the films, whereby to form the automotive carbon fiber-filled sheet molding compound.

Abstract: The present invention involves a carbon fiber-filled sheet molding compound and method of manufacturing the same. The invention comprises providing chopped automotive carbon fibers, a predetermined resin paste, a first carrier film, and a second carrier film. The method further involves coating substantially completely one side of one of the first and second carrier films with the predetermined resin paste to define a coated side, depositing the chopped automotive carbon fibers onto the coated side, and covering the deposited carbon fibers with the second carrier film to define a compactible carbon-filled laminate. The method further includes compacting the carbon-filled laminate to admix the resin paste with the carbon fibers between the films, whereby to form the automotive carbon fiber-filled sheet molding compound.

Abstract: A mold for use in a reaction injection molding method and system to make a reinforced polymeric article having reduced surface defects includes a novel gating system. The mold includes a pair of mold sections which define a closed, article-forming cavity, an injection aperture, and an after-mixer which helps to form a plurality of flow paths which extend downstream from the injection aperture toward the article-forming cavity to further mix a curable, multi-component, reaction fluid mixture including a filler. The flow paths are also at least partially defined by an elongated film gate and an elongated runner which extends along and is in fluid communication with the film gate along substantially the entire length of the film gate. The runner has a closed end and an open end into which a fluid mixture for the article flows for distribution by the runner into the film gate.

Abstract: The invention relates to reinforced composite inner roof panels of the sandwich-type having a cellular core. In a method for making a inner roof panel of the invention, a stack is formed that is made up of: an upper skin made of a reinforced thermoplastic material; a cellular core made of a thermoplastic material; and a bottom skin made of a reinforced thermoplastic material. The upper and lower skins and the cellular core are formed together and have regions of reduced thickness and regions of increased thickness that may provide head impact absorbing characteristics or form structural components of the passenger compartment. Examples of structural components that may be formed include HVAC ducts, wiring conduits, video display panel mounts or air bag receptacles.

Abstract: A method and system of manufacturing an air bag cover assembly utilizing infrared radiation is disclosed. The assembly includes a front panel, a back plate, a switch and infrared-absorbing material. Initially, the front panel and the back plate are positioned so that inner surfaces of the front panel and the back plate define a switch pocket therebetween. Then the switch is positioned in the switch pocket. Thereafter, infrared radiation is directed at the infrared-absorbing material for a time sufficient to heat the infrared-absorbing material to a desired temperature. The amount of heat applied to the infrared-absorbing material by the infrared radiation is controlled by a controller. Finally, the heated material cools to fixedly secures the back plate to the front panel. The heated material may be forced to flow prior to cooling.

Abstract: A cured resin and fiber part generally can be manufactured by providing a mold that defines a cavity having at least one shape-defining surface. An in-mold paint sheet having a bonding side and a finish side can be positioned in the cavity of the mold such that the finish side of the in-mold paint sheet is positioned adjacent to the shape-defining surface of the mold. A mixture of a thermoset resin and a plurality of reinforcing fibers are then introduced into the cavity of the mold such that the resin and fiber mixture contacts the bonding side of the in-mold paint sheet. The in-mold paint sheet and resin and fiber mixture are then compressed in the mold while being heated causing the resin and fiber mixture to be cured and bonded to the in-mold paint sheet resulting in a part having the finish side of the in-mold paint sheet as a finished surface of the part.