Abstract: The present application provides a novel drug screening platform designed to identify drugs that favorably modulate cellular bioenergetics in the human brain of a zebrafish which has been modified by altering a teleost gene that corresponds to a human gene associated with a brain dysfunction disorder (such as epilepsy). The drug screening platform are also useful for determining a mutation in a human gene associated with a brain dysfunction disorder that is associated with a human individual responsive to the treatment of a compound. Also provided are modified teleosts useful for the methods described herein.
Type:
Grant
Filed:
January 16, 2015
Date of Patent:
May 25, 2021
Assignee:
Path Therapeutics, Inc.
Inventors:
Deborah M. Kurrasch, Jong Rho, Kingsley Ibhazehiebo
Abstract: The present application provides a novel drug screening platform designed to identify drugs that favorably modulate cellular bioenergetics in the human brain of a zebrafish which has been modified by altering a teleost gene that corresponds to a human gene associated with a brain dysfunction disorder (such as epilepsy). The drug screening platform are also useful for determining a mutation in a human gene associated with a brain dysfunction disorder that is associated with a human individual responsive to the treatment of a compound. Also provided are modified teleosts useful for the methods described herein.
Type:
Application
Filed:
January 16, 2015
Publication date:
November 24, 2016
Applicant:
Path Therapeutics, Inc.
Inventors:
Deborah M. KURRASCH, Jong RHO, Kingsley IBHAZEHIEBO