Patents Assigned to PATH VACCINE SOLUTIONS
  • Selectively disrupted whole-cell vaccine
    Patent number: 9827299
    Abstract: The present invention provides for immunogenic compositions and methods for producing an immunogenic composition with multiple immunity-inducing fractions of killed, whole-cell Streptococcus pneumoniae by selectively disrupting a whole cell bacterial preparation in such a manner that a soluble fraction that induces a primarily antibody response, and a cellular fraction that induces a primarily antibody-independent response, remain in the immunogenic composition.
    Type: Grant
    Filed: October 12, 2010
    Date of Patent: November 28, 2017
    Assignees: Children's Medical Center Corporation, Path Vaccine Solutions, Fundacao Butantan
    Inventors: Richard Malley, Porter Anderson, Yingjie Lu, George A. Robertson, Mark Alderson, Jean-Francois Lucien Maisonneuve, Andrea Maria Tate, Waldely de Oliveira Dias, Viviane Maimoni Gonçalves
  • SELECTIVELY DISRUPTED WHOLE-CELL VACCINE
    Publication number: 20120251577
    Abstract: The present invention provides for immunogenic compositions and methods for producing an immunogenic composition with multiple immunity-inducing fractions of killed, whole-cell Streptococcus pneumoniae by selectively disrupting a whole cell bacterial preparation in such a manner that a soluble fraction that induces a primarily antibody response, and a cellular fraction that induces a primarily antibody-independent response, remain in the immunogenic composition.
    Type: Application
    Filed: October 12, 2010
    Publication date: October 4, 2012
    Applicants: CHILDREN'S MEDICAL CENTER CORPORATION, FUNDACAO BUTANTAN, PATH VACCINE SOLUTIONS
    Inventors: Richard Malley, Porter Anderson, Yingjie Lu, George A. Robertson, Mark Alderson, Jean-Francois Lucien Maisonneuve, Andrea Maria Tate, Waldely de Oliveira Dias, Viviane Maimoni Gonçalves