Patents Assigned to PATHEON SOFTGELS INC.
  • Patent number: 10555901
    Abstract: Described herein are oral pharmaceutical compositions suitable for chewing, sucking, or buccal dissolution comprising soft gel capsules and liquid fills, methods for making the same, and methods for treating subjects in need thereof with such capsules. In particular, oral pharmaceutical compositions comprising chewable, suckable, or dissolvable soft gel capsules with various flowable fill compositions are described.
    Type: Grant
    Filed: October 27, 2017
    Date of Patent: February 11, 2020
    Assignee: PATHEON SOFTGELS INC
    Inventors: YinYan Zhao, Yunhua Hu, Mervin Williams, Jr., Tatyana Dyakonov, Saujanya Gosangari, Chue Yang, Henricus Marinus Gerardus Maria Van Duijnhoven, Martin Piest, Aqeel A Fatmi
  • Patent number: 10478429
    Abstract: Described herein are oral abuse deterrent pharmaceutical compositions, methods for making the same, and methods for treating pain by administering the pharmaceutical composition to a subject in need thereof. In particular, an oral abuse deterrent pharmaceutical composition comprising a soft capsule and a controlled release matrix comprising oxycodone are described.
    Type: Grant
    Filed: October 27, 2017
    Date of Patent: November 19, 2019
    Assignee: Patheon Softgels, Inc.
    Inventors: Justin Hughey, Saujanya Gosangari, Chue Hue Yang
  • Patent number: 10357467
    Abstract: Described herein are soft capsules and enteric soft capsules comprising cationic Type A gelatin and acid insoluble enteric polymers. In particular, the compositions and methods for manufacturing all-natural enteric soft capsules comprising Type A gelatin and matrix fills are described. In one embodiment, the enteric soft capsules comprise active ingredients such as non-steroidal anti-inflammatory drugs (NSAIDs). In another embodiment, the enteric soft capsule comprises matrix fills of omega-3 fatty acids.
    Type: Grant
    Filed: May 30, 2018
    Date of Patent: July 23, 2019
    Assignee: Patheon Softgels, Inc.
    Inventors: Yunhua Hu, Martin Piest, Qi Fang, Henricus M. G. M. van Duijnhoven
  • Patent number: 10342763
    Abstract: A matrix formulation for a soft chewable capsule is provided which includes a gel-forming composition, a plasticizer, a polymer modifier, and water. The polymer modifier may be a carboxylic acid or other organic compound that alters the physical and/or chemical properties of the capsule formulation. A chewable soft capsule is also provided, having enhanced organoleptic and processing properties. An active material may be delivered to a user using this dosage form. A method of forming the chewable soft capsule is also provided.
    Type: Grant
    Filed: December 5, 2017
    Date of Patent: July 9, 2019
    Assignee: Patheon Softgels, Inc.
    Inventors: EmadEldin M. Hassan, Warren Walter Kindt, Roger E. Gordon
  • Patent number: 10335375
    Abstract: Described herein are abuse deterrent oral pharmaceutical compositions, methods for making the same, and methods of treatment using such compositions. In particular, oral pharmaceutical compositions that mitigate the risk of overingestion of one or more active pharmaceutical ingredients are described.
    Type: Grant
    Filed: May 29, 2018
    Date of Patent: July 2, 2019
    Assignee: Patheon Softgels, Inc.
    Inventors: Justin Hughey, Jason Vaughn
  • Patent number: 10335405
    Abstract: Described herein are controlled release oral pharmaceutical compositions and methods for making the same. These pharmaceutical compositions provide a non-burst release of one or more active pharmaceutical ingredients. In particular, a non-burst controlled release oral pharmaceutical composition comprising a capsule and an abuse deterrent controlled release matrix comprising one or more active pharmaceutical ingredients are described.
    Type: Grant
    Filed: May 3, 2017
    Date of Patent: July 2, 2019
    Assignee: Patheon Softgels, Inc.
    Inventors: Justin R. Hughey, Chue Hue Yang
  • Patent number: 10226432
    Abstract: Described herein are enteric soft capsules comprising gastric resistant polymers and gelatin and methods for manufacturing the same. The enteric soft capsules described herein have enhanced enteric and elastic properties and are simpler to manufacture and produce.
    Type: Grant
    Filed: September 28, 2017
    Date of Patent: March 12, 2019
    Assignee: Patheon Softgels Inc.
    Inventors: Helena Maria de Albuquerque Ferreira Teles, Henricus Marinus Gerardus Maria van Duijnhoven, Mélanie Françoise Géraldine Bayarri
  • Patent number: 10195211
    Abstract: Described herein are topical, non-systemic, slow releasing oral pharmaceutical compositions, methods for making the same, and methods for treating subjects in need thereof with such compositions. In particular, the oral composition provides topical, non-systemic administration of one or more active pharmaceutical ingredients to the oral cavity and upper gastrointestinal track, including the esophagus. In one embodiment, the pharmaceutical composition provides topical corticosteroids to the esophagus and oral cavity.
    Type: Grant
    Filed: October 27, 2017
    Date of Patent: February 5, 2019
    Assignee: Patheon Softgels, Inc.
    Inventors: YinYan Zhao, Justin Hughey, Jason Vaughn, Qi Fang
  • Patent number: 10188624
    Abstract: Described herein are pharmaceutical compositions comprising polyunsaturated fatty acids and methods of manufacturing the same. In particular, described herein are pharmaceutical compositions comprising soft enteric capsules comprising omega-3 polyunsaturated fatty acids. The oral pharmaceutical compositions described herein are useful as nutritional supplements or for the treatment of cardiovascular-related diseases, such as hyper dyslipidemia and high triglyceride levels.
    Type: Grant
    Filed: February 13, 2018
    Date of Patent: January 29, 2019
    Assignee: Patheon Softgels Inc.
    Inventors: Peijin Zhang, Aqeel A. Fatmi
  • Patent number: 10188662
    Abstract: Described herein are oral pharmaceutical compositions suitable for chewing, sucking, or buccal dissolution comprising non-systemic corticosteroid soft lozenges, methods for making the same, and methods for treating subjects in need thereof with such lozenges. In particular, the oral composition provides topical, non-systemic administration of one or more active pharmaceutical ingredients to the oral cavity and upper gastrointestinal track, including the esophagus. In one embodiment, the oral pharmaceutical compositions comprise chewable, suckable, or buccally-dissolvable soft lozenges for the treatment of esophageal lesions. The soft lozenges provide topical, non-systemic delivery of corticosteroids to the esophagus and oral cavity.
    Type: Grant
    Filed: October 27, 2017
    Date of Patent: January 29, 2019
    Assignee: Patheon Softgels, Inc.
    Inventors: YinYan Zhao, Justin Hughey, Jason Vaughn, Qi Fang
  • Patent number: 10182990
    Abstract: Gastric resistant film-forming compositions are described herein. The composition contains a gastric resistant natural polymer, a film-forming natural polymer, and optionally a gelling agent. Suitable gastric resistant natural polymers include polysaccharides such as pectin and pectin-like polymers. The film-forming composition can be used to prepare soft or hard shell gelatin capsules which can encapsulate a liquid or semi-solid fill material or a solid tablet (SOFLET®) containing an active agent and one or more pharmaceutically acceptable excipients. Alternatively, the composition can be administered as a liquid with an active agent dissolved or dispersed in the composition. The compositions are not only gastric resistant but may also prevent gastric reflux associated with odor causing liquids, such as fish oil or garlic oil, encapsulated in a unit dosage form and esophageal irritation due to the reflux of irritant drugs delivered orally.
    Type: Grant
    Filed: May 23, 2017
    Date of Patent: January 22, 2019
    Assignee: Patheon Softgels Inc.
    Inventor: Nachiappan Chidambaram
  • Patent number: 10182989
    Abstract: Described herein are pharmaceutical enteric soft capsules that do not contain gelatin as a film-forming polymer. In particular, compositions and methods for manufacturing enteric soft capsules comprising carrageenans as film forming polymers are disclosed.
    Type: Grant
    Filed: April 23, 2018
    Date of Patent: January 22, 2019
    Assignee: Patheon Softgels Inc.
    Inventors: Qi Fang, Josh Heflin, Madhu Hariharan
  • Patent number: 10182993
    Abstract: Described herein are controlled release oral pharmaceutical compositions for delivering active pharmaceutical ingredients to the colon and methods for making the same. In particular, an oral pharmaceutical composition comprising a soft capsule and a controlled release matrix for delivering active pharmaceutical ingredients to the colon are described.
    Type: Grant
    Filed: April 5, 2016
    Date of Patent: January 22, 2019
    Assignee: Patheon Softgels Inc.
    Inventors: Chue Hue Yang, Tatyana Dyakonov, George Vamvakas, Aqeel A. Fatmi
  • Patent number: 10182991
    Abstract: A hard or soft capsule is disclosed comprising a shell and a fill material, wherein the shell comprises an interpenetrating network comprising a silk polymer and a film-forming natural polymer. A method of making a hard or soft capsule is also disclosed, comprising dissolving a silk protein in a solvent system to form a solubilized silk protein solution; mixing the solubilized silk protein solution with a film-forming natural polymer to form a homogenous shell material; and encapsulating a fill material with the homogenous shell material.
    Type: Grant
    Filed: April 23, 2018
    Date of Patent: January 22, 2019
    Assignee: Patheon Softgels Inc.
    Inventors: Tatyana Dyakonov, Derek Bush, Saujanya L. Gosangari, Chue Hue Yang, Shingai Majuru, Aqeel Fatmi
  • Patent number: 10182992
    Abstract: Described herein are abuse deterrent controlled release oral pharmaceutical compositions comprising and methods for making the same. In particular, an abuse deterrent controlled release oral pharmaceutical composition comprising a soft capsule and an abuse deterrent controlled release matrix comprising an active pharmaceutical ingredient are described.
    Type: Grant
    Filed: April 6, 2015
    Date of Patent: January 22, 2019
    Assignee: Patheon Softgels Inc.
    Inventors: George Vamvakas, Aqeel A Fatmi
  • Patent number: 10028925
    Abstract: Described herein are oral pharmaceutical compositions comprising liquid dosage forms of sodium naproxen in soft gel capsules. In one embodiment, the pharmaceutical composition comprises sodium naproxen, 0.2-1.0 mole equivalents of a de-ionizing agent per mole of naproxen, polyethylene glycol, and one or more solubilizers such as propylene glycol, polyvinyl pyrrolidone or a combination thereof.
    Type: Grant
    Filed: May 10, 2017
    Date of Patent: July 24, 2018
    Assignee: Patheon Softgels, Inc.
    Inventors: Nachiappan Chidambaram, Aqeel A Fatmi
  • Patent number: 10022344
    Abstract: Described herein are oral pharmaceutical compositions comprising liquid dosage forms of sodium naproxen in soft gel capsules. In one embodiment, the pharmaceutical composition comprises sodium naproxen, 0.2-1.0 mole equivalents of a de-ionizing agent per mole of naproxen, polyethylene glycol, and one or more solubilizers such as propylene glycol, polyvinyl pyrrolidone or a combination thereof.
    Type: Grant
    Filed: November 20, 2017
    Date of Patent: July 17, 2018
    Assignee: Patheon Softgels, Inc.
    Inventors: Nachiappan Chidambaram, Aqeel A. Fatmi
  • Patent number: 9987240
    Abstract: Described herein are soft capsules and enteric soft capsules comprising cationic Type A gelatin and acid insoluble enteric polymers. In particular, the compositions and methods for manufacturing all-natural enteric soft capsules comprising Type A gelatin and matrix fills are described. In one embodiment, the enteric soft capsules comprise active ingredients such as non-steroidal anti-inflammatory drugs (NSAIDs). In another embodiment, the enteric soft capsule comprises matrix fills of omega-3 fatty acids.
    Type: Grant
    Filed: September 28, 2017
    Date of Patent: June 5, 2018
    Assignee: Patheon Softgels, Inc.
    Inventors: Yunhua Hu, Martin Piest, Qi Fang, Henricus M. G. M. van Duijnhoven
  • Patent number: 9980916
    Abstract: Enteric soft capsules containing carrageenans as the film-forming polymer have been developed. The enteric soft capsules comprise iota carrageenan and kappa carrageenan, methacrylic acid copolymers, modifeid starch fillers, plasticizers, water, and other excipients. Such enteric soft capsules are stable at pH 1.2 for at least 2 hours and dissolve at pH 6.8 within about 30 minutes. Methods for manufacturing enteric soft capsules comprising carrageenans are also exemplified.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: May 29, 2018
    Assignee: Patheon Softgels, Inc.
    Inventors: Qi Fang, Josh Heflin, Madhu Hariharan
  • Patent number: 9968561
    Abstract: A hard or soft capsule is disclosed comprising a shell and a fill material, wherein the shell comprises an interpenetrating network comprising a silk polymer and a film-forming natural polymer. A method of making a hard or soft capsule is also disclosed, comprising dissolving a silk protein in a solvent system to form a solubilized silk protein solution; mixing the solubilized silk protein solution with a film-forming natural polymer to form a homogenous shell material; and encapsulating a fill material with the homogenous shell material.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: May 15, 2018
    Assignee: Patheon Softgels Inc.
    Inventors: Tatyana Dyakonov, Derek Bush, Saujanya L. Gosangari, Yang Hue Chue, Shingai Majuru, Aqeel Fatmi