Patents Assigned to Pathogen Removal and Diagnostic Technologies, Inc.
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Patent number: 9678085Abstract: Ligands that bind to prion proteins and methods for using the ligands for detecting or removing a prion protein from a sample, such as a biological fluid or an environmental sample. The ligands are capable of binding to one or more forms of prion protein including cellular prion protein (PrPc), infectious prion protein (PrPsc), and recombinant prion protein (PrPr). Prions from various species, including humans and hamsters, are bound by the ligands. Also provided is a method of treating or retarding the development of a prion-associated pathology in a subject.Type: GrantFiled: October 31, 2013Date of Patent: June 13, 2017Assignees: Pathogen Removal and Diagnostic Technologies Inc., North Carolina State UniversityInventors: David J. Hammond, Julia T. Lathrop, Larisa Cervenakova, Ruben G. Carbonell
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Patent number: 9091006Abstract: The present invention describes a novel process for the conformal coating of polymer fibers of nonwoven substrates. This process is based on modification of polymer fiber surfaces by controlling the degree of etching and oxidation to improve adhesion of initiators to the surface and to facilitate subsequent conformal polymer grafting. The modified fiber surfaces render new functionalities to the surface, such as increased hydrophilicity, attached ligands or changed surface energy. The invention includes the modified polymer fibers produced by the process described herein.Type: GrantFiled: June 10, 2009Date of Patent: July 28, 2015Assignees: Pathogen Removal and Diagnostic Technologies, Inc., North Carolina State UniversityInventors: Yong Zheng, Samana Roy Chowdhury, Patrick Vasconcelos Gurgel, Haiyan Liu, Ruben G. Carbonell
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Publication number: 20140206021Abstract: Ligands that bind to prion proteins and methods for using the ligands for detecting or removing a prion protein from a sample, such as a biological fluid or an environmental sample. The ligands are capable of binding to one or more forms of prion protein including cellular prion protein (PrPc), infectious prion protein (PrPsc), and recombinant prion protein (PrPr). Prions from various species, including humans and hamsters, are bound by the ligands.Type: ApplicationFiled: October 31, 2013Publication date: July 24, 2014Applicants: North Carolina State University, Pathogen Removal and Diagnostic Technologies, Inc.Inventors: David J. Hammond, Julia T. Lathrop, Larisa Cervenakova, Ruben G. Carbonell
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Patent number: 8604161Abstract: Ligands that bind to prion proteins and methods for using the ligands for detecting or removing a prion protein from a sample, such as a biological fluid or an environmental sample. The ligands are capable of binding to one or more forms of prion protein including cellular prion protein (PrPc), infectious prion protein (PrPsc), and recombinant prion protein (PrPr). Prions from various species, including humans and hamsters, are bound by the ligands. Also provided is a method of treating or retarding the development of a prion-associated pathology in a subject.Type: GrantFiled: February 22, 2008Date of Patent: December 10, 2013Assignees: Pathogen Removal and Diagnostic Technologies Inc., North Carolina State UniversityInventors: David J. Hammond, Julia T. Lathrop, Larisa Cervenakova, Ruben G. Carbonell
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Publication number: 20120129150Abstract: The invention provides devices, test kits and methods for removing target agents from a sample. The device contains one or more porous matrices having pore sizes larger than 10 ?m, and a plurality of particles impregnated therein. The target agents attach the device and are removed from the sample.Type: ApplicationFiled: December 7, 2011Publication date: May 24, 2012Applicant: PATHOGEN REMOVAL AND DIAGNOSTIC TECHNOLOGIES INC.Inventor: Ruben G. Carbonell
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Patent number: 8163563Abstract: The invention provides devices, test kits and methods for removing target agents from a sample. The device contains one or more porous matrices having pore sizes larger than 10 ?m, and a plurality of particles impregnated therein. The target agents attach the device and are removed from the sample.Type: GrantFiled: June 9, 2005Date of Patent: April 24, 2012Assignee: Pathogen Removal and Diagnostic Technologies, Inc.Inventor: Ruben G. Carbonell
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Patent number: 8101425Abstract: The invention provides devices, test kits and methods for removing target agents from a sample. The device contains one or more porous matrices having pore sizes larger than 10 ?m, and a plurality of particles impregnated therein. The target agents attach the device and are removed from the sample.Type: GrantFiled: June 9, 2005Date of Patent: January 24, 2012Assignee: Pathogen Removal and Diagnostic Technologies Inc.Inventor: Ruben G. Carbonell
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Publication number: 20110268911Abstract: The present invention describes a novel process for the conformal coating of polymer fibers on nonwoven substrates. This process is based on the modification of polymer fiber surfaces by controlling the degree of etching and oxidation, which improves adhesion of initiators to the surface and facilitates subsequent conformal polymer grafting. The modified fiber surfaces render new functionalities to the surface, such as increasing hydrophilicity, attaching ligands or changing surface energy. The invention includes the modified polymer fibers produced by the process described herein.Type: ApplicationFiled: June 10, 2009Publication date: November 3, 2011Applicants: NORTH CAROLINA STATE UNIVERSITY, PATHOGEN REMOVAL AND DIAGNOSTIC TECHNOLOGIES, INC.Inventors: Yong Zheng, Sumana Roy Chowdhury, Patrick Vasconcelos Gurgel, Haiyan Liu, Ruben G. Carbonell
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Patent number: 7863411Abstract: Ligands that bind to prion proteins and methods for using the ligands for detecting or removing a prion protein from a sample, such as a biological fluid or an environmental sample. The ligands are capable of binding to one or more forms of prion protein including cellular prion protein (PrPc), infectious prion protein (PrPsc), and recombinant prion protein (PrPr). Prions from various species, including humans and hamsters, are bound by the ligands. Also provided is a method of treating or retarding the development of a prion-associated pathology in a subject.Type: GrantFiled: December 3, 2003Date of Patent: January 4, 2011Assignees: Pathogen Removal and Diagnostics Technologies Inc., North Carolina State UniversityInventors: David J. Hammond, Julia T. Lathrop, Larisa Cervenakova, Ruben G. Carbonell
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Patent number: 7510848Abstract: Prion protein binding materials and methods for using the binding materials to detect or remove a prion protein from a sample, such as a biological fluid or an environmental sample. The binding materials are capable of binding to one or more forms of prion protein including cellular prion protein (PrPc), infectious prion protein (PrPsc), recombinant prion protein (PrPr), and proteinase resistant prion protein (PrPres). Prions from various species, including humans and hamsters, are bound by the binding materials.Type: GrantFiled: October 13, 2004Date of Patent: March 31, 2009Assignees: North Carolina State University, Pathogen Removal and Diagnostic Technologies Inc.Inventors: David J. Hammond, Ruben G. Carbonell, Honglue Shen, Patrick V. Gurgel, Viterose Wiltshire-Lyerly, Steven J. Burton
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Patent number: 7393658Abstract: Prion protein binding materials and methods for using the binding materials to detect or remove a prion protein from a sample, such as a biological fluid or an environmental sample. The binding materials are capable of binding to one or more forms of prion protein including cellular prion protein (PrPc), infectious prion protein (PrPsc), recombinant prion protein (PrPr), and proteinase resistant prion protein (PrPres). Prions from various species, including humans and hamsters, are bound by the binding materials.Type: GrantFiled: April 2, 2004Date of Patent: July 1, 2008Assignees: Pathogen Removal and Diagnostic Technologies, Inc., North Carolina State UniversityInventors: Ruben G. Carbonell, Honglue Shen, Patrick V. Gurgel, Viteros Wiltshire-Lyerly, David J. Hammond, Steven J. Burton
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Publication number: 20060160064Abstract: The invention provides devices, test kits and methods for removing target agents from a sample. The device contains one or more porous matrices having pore sizes larger than 10 ?m, and a plurality of particles impregnated therein. The target agents attach the device and are removed from the sample.Type: ApplicationFiled: June 9, 2005Publication date: July 20, 2006Applicant: (PRDT) PATHOGEN REMOVAL AND DIAGNOSTIC TECHNOLOGIES INC.Inventor: Ruben Carbonell