Abstract: A method and apparatus for the rapid and reliable preparation of a sample for use in testing for target analytes such as bacteria, viruses, toxins and pathogenic agents in various products. A sample for testing the target analyte is collected from various sources. The method for sample preparation provides for an express process for preparing collected samples for testing. The collected sample may be concentrated by centrifugation, filtration, or other means suitable for sample concentration, homogenized with the addition of a broth and enriched for specified period of time. Immunomagnetic separation of the sample occurs with receptor-coated magnetic microspheres in different test-specific formulations (singleplex or multiplex). An automatic testing system is disclosed which includes a biological testing cassette, in which testing of the sample occurs using liquid crystal diagnostic methodologies.
Type:
Application
Filed:
May 21, 2020
Publication date:
September 24, 2020
Applicant:
Pathogen Systems, Inc. dba Crystal Diagnostics Ltd
Abstract: Chromonic azo dyes are particular types of chromonic molecules that are alignable homeotropically (aggregated molecules stacked perpendicularly to the surface) on different types of substrates, often without the need of any special surface treatment. This feature enables the optimization of a detection device with increased sensitivity based of the alignment distortion created by a biological immune complex.
Type:
Application
Filed:
March 30, 2020
Publication date:
July 16, 2020
Applicant:
Pathogen Systems, Inc. dba Crystal Diagnostics Ltd
Abstract: A novel detection system and method is presented, where a two-bead receptor method is used for capturing pathogens, with one type of bead being magnetic and having a size of 3 microns or smaller, and the other type being polymeric and having a size of 3 microns or larger. The first type is used to concentrate a pathogen; the latter is used to create a detectable signal. Fast sensitive detection is achieved by collecting the optical signal created by the distortion of a homeotropically aligned chromonic azo dye in the presence of captured pathogens.
Type:
Application
Filed:
October 16, 2019
Publication date:
February 13, 2020
Applicant:
Pathogen Systems, Inc. dba Crystal Diagnostics Ltd
Abstract: A method and apparatus for the rapid and reliable preparation of a sample for use in testing for target analytes such as bacteria, viruses, toxins and pathogenic agents in various products. A sample for testing the target analyte is collected from various sources. The method for sample preparation provides for an express process for preparing collected samples for testing. The collected sample may be concentrated by centrifugation, filtration, or other means suitable for sample concentration, homogenized with the addition of a broth and enriched for specified period of time. Immunomagnetic separation of the sample occurs with receptor-coated magnetic microspheres in different test-specific formulations (singleplex or multiplex). An automatic testing system is disclosed which includes a biological testing cassette, in which testing of the sample occurs using liquid crystal diagnostic methodologies.
Type:
Application
Filed:
June 4, 2018
Publication date:
October 4, 2018
Applicant:
Pathogen Systems, Inc. dba Crystal Diagnostics Ltd
Abstract: Chromonic azo dyes are particular types of chromonic molecules that are alignable homeotropically (aggregated molecules stack perpendicularly to the surface) on different types of substrates, often without the need of any special surface treatment. This feature enables the optimization of a detection device with increased sensitivity based of the alignment distortion created by a biological immune complex.
Type:
Application
Filed:
June 1, 2018
Publication date:
September 27, 2018
Applicant:
Pathogen Systems, Inc. dba Crystal Diagnostics Ltd
Abstract: A method and apparatus for the rapid and reliable preparation of a sample for use in testing for target analytes such as bacteria, viruses, toxins and pathogenic agents in various products. A sample for testing the target analyte is collected from various sources. The method for sample preparation provides for an express process for preparing collected samples for testing. The collected sample may be concentrated by centrifugation, filtration, or other means suitable for sample concentration, homogenized with the addition of a broth and enriched for specified period of time. Immunomagnetic separation of the sample occurs with receptor-coated magnetic microspheres in different test-specific formulations (singleplex or multiplex). An automatic testing system is disclosed which includes a biological testing cassette, in which testing of the sample occurs using liquid crystal diagnostic methodologies.
Type:
Application
Filed:
March 8, 2016
Publication date:
October 6, 2016
Applicant:
Pathogen Systems, Inc. dba Crystal Diagnostics Ltd
Abstract: Chromonic azo dyes are particular types of chromonic molecules that are alignable homeotropically (aggregated molecules stack perpendicularly to the surface) on different types of substrates, often without the need of any special surface treatment. This feature enables the optimization of a detection device with increased sensitivity based of the alignment distortion created by a biological immune complex.
Type:
Application
Filed:
November 13, 2015
Publication date:
May 19, 2016
Applicant:
Pathogen Systems, Inc. dba Crystal Diagnostics Ltd