Abstract: A multi-brush denture cleaning device includes a handle having one end adapted for holding both a first and second brush and another opposing end for holding a different third brush. The first brush has bristles protruding in one direction, and the second brush has bristles protruding in a perpendicular orientation with respect to the first brush. The third brush has bristles protruding in the same direction as the first brush. The handle may include a hand grip portion interposed between the two ends thereof. The brushes in the multi-brush denture cleaning device have varying stiffness so that the first and second brushes are harder than the third brush. The handle has two extending portions which are each at acute angles with respect to the longitudinal axis of the handle, and preferably being acutely angled with respect to each other, wherein one extending portion holds the first brush and the second extending portion holds the second brush. Each of the brushes has a different average bristle length.