Abstract: A preparation which is compatible with the skin for the treatment of labial disease and acne. The preparation comprises a mixture of:(a) at least one compound selected from an antiseptic compound and an anesthetic compound which is:(i) a terpene,(ii) a phenolic compound, or(iii) an alcohol;(b) a quaternary ammonium antiseptic compound;(c) an antiseptic compound selected from compounds containing iodine, salts thereof and complexes thereof dissolved in an organic skin penetrating solvent, wherein said solvent comprises acetone.