Abstract: A syringe having a cylinder and a piston longitudinally and rotationably movable in the cylinder. First and second sets of one-way ratchet shoulders and ratchet keys are provided between the cylinder and the piston in which the first set of shoulders and key, when engaged, allow movement of the piston in one longitudinal direction but prevent movement in the opposite second direction. The second set of shoulders and key, when engaged, allow movement of the piston in the second direction but prevent movement in the first direction. A rotational control between the piston and the cylinder provides for sequentially disengaging and engaging the first and second sets of ratchet shoulders and keys upon rotation of the piston relative to the cylinder for operating the syringe for a single cycle.