Abstract: A syringe holder and applicator provides a unique latch mechanism for mounting a syringe on a slider and loading the syringe into a holder. The latch mechanism pivots on the slider in such a way that it may be engaged and retracted against the force of a spring, pulling the slider into a cocked position, pivoted to a position that allows the syringe to be placed on the slider and mounted in the holder, and then pivoted into the cocked position, locking the syringe to the holder and conditioning the device for administering an injection. The slider and syringe are maintained in a position of retraction against the spring by a detent which may be released by a finger operated contact or trigger button.