Abstract: A system utilizing five or less body worn sensors may be used to profile the motor function of Parkinson's disease patients, integrate the outcome with patient self-reported information and translate the results to clinically relevant information, valuable for the monitoring of Parkinson's disease progression and symptom manifestation. The hardware of the system may deploy algorithms for the offline processing of the sensors' data, once the wearable monitoring devices are docked for charging, with no intervention required by the user. The system may also allow patients to mount the wearable devices featuring the sensors to any of a limited number of body parts, without taking care to mount each monitoring device to a specific body part. Finally, the system may allow a physician to register for a subscription-based service, pairing him/her with patients using the system, and granting him/her permission to remotely review the disease progression of the patients, as calculated by the system.