Patents Assigned to PDS Biotechnology Corporation
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Patent number: 11911465Abstract: The present disclosure provides vaccine compositions comprising at least one adjuvant and at least one antigen, wherein the adjuvant is a cationic lipid. The disclosure also provides methods of treating a disease in a mammal, methods of preventing a disease in a mammal, and methods of effecting antigen cross presentation to induce a humoral immune response and a cellular immune response in a mammal utilizing the vaccine compositions. Cross presentation of various antigens can be achieved by formulating the specific antigens with cationic lipids possessing adjuvant properties.Type: GrantFiled: July 22, 2021Date of Patent: February 27, 2024Assignee: PDS Biotechnology CorporationInventors: Frank Bedu-Addo, Eric Jacobson, Kenya Johnson
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Patent number: 11911359Abstract: The present invention provides compositions and methods for stimulating an immune response using cationic lipids alone or in combination with antigens.Type: GrantFiled: November 3, 2014Date of Patent: February 27, 2024Assignee: PDS Biotechnology CorporationInventors: Weihsu Chen, Weili Yan, Kenya Johnson, Gregory Conn, Frank Bedu-Addo, Leaf Huang
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Patent number: 11904015Abstract: The present disclosure provides vaccine compositions comprising at least one adjuvant and at least one antigen, wherein the adjuvant is a cationic lipid. The disclosure also provides methods of treating a disease in a mammal, methods of preventing a disease in a mammal, and methods of effecting antigen cross presentation to induce a humoral immune response and a cellular immune response in a mammal utilizing the vaccine compositions. Cross presentation of various antigens can be achieved by formulating the specific antigens with cationic lipids possessing adjuvant properties.Type: GrantFiled: April 18, 2019Date of Patent: February 20, 2024Assignee: PDS BIOTECHNOLOGY CORPORATIONInventors: Frank Bedu-Addo, Eric Jacobson, Kenya Johnson
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Patent number: 11801257Abstract: A composition and method for activating immune cells ex-vivo, or inducing an immune response in a subject including a composition comprising at least one chiral cationic lipid. The chiral cationic lipid in one embodiment comprises a nonsteroidal cationic lipid having a structure represented by formula (I); wherein in R1 is a quaternary ammonium group, Y1 is a space chosen from a hydrocarbon chain, an ester, a ketone, and a peptide, C* is a chiral carbon, R2 and R3 are independently chosen from a saturated fatty acid, an unsaturated fatty acid, an ester-linked hydrocarbon, phosphor-diesters, and combination thereof.Type: GrantFiled: June 12, 2020Date of Patent: October 31, 2023Assignee: PDS BIOTECHNOLOGY CORPORATIONInventors: Elizabeth Ann Vasievich, Weihsu Claire Chen, Kenya N. Toney Johnson, Gregory Conn, Frank Bedu-Addo, Leaf Huang
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Patent number: 11612652Abstract: The invention covers the use of certain classes of lipids including cationic lipids in ex-vivo dendritic cell therapies. The cationic lipids enhance antigen uptake, processing and presentation of the processed antigens by dendritic cells to CD8+ and CD4+ T-cells via the MHC classes I and II presentation pathways respectively. Antigen uptake via cationic lipid by dendritic cells result in significant lowering of the population of the immune suppressive regulatory T cells in the tumors and a significant increase of the tumor targeting cytotoxic T-cells. Loss of regulatory T cells and increase of tumor specific cytotoxic cells are conducive to effective elimination of the tumors.Type: GrantFiled: November 14, 2016Date of Patent: March 28, 2023Assignee: PDS Biotechnology CorporationInventors: Frank Bedu-Addo, Greg Conn, Siva K. Gandhapudi, Martin Ward, Jerold Woodward
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Patent number: 11401306Abstract: Novel human papillomovirus immunogenic compositions and methods of use thereof are provided. The compositions comprise unique combinations of multi-epitope peptide sequences specifically selected and designed to be effectively processed and cross-presented to T-cells. The peptides utilized in the compositions display high levels of binding with HLA-supertypes. The immunogenic compositions are broadly applicable to large proportions of target populations. The compositions comprise adjuvants such as cationic lipids.Type: GrantFiled: October 4, 2017Date of Patent: August 2, 2022Assignee: PDS Biotechnology CorporationInventors: Frank Bedu-Addo, Greg Conn, Martin Ward, Jerold Woodward
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Patent number: 10828364Abstract: The present disclosure provides vaccine compositions comprising at least one adjuvant and at least one therapeutic factor. The disclosure also provides methods of reducing an immune suppressor cell population in a mammal, methods of argumenting an immune response in a mammal, and methods of treating a diseases in a mammal utilizing the vaccine compositions.Type: GrantFiled: March 28, 2019Date of Patent: November 10, 2020Assignees: PDS Biotechnology Corporation, THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SEC. OF THE DEPT. OF HEALTH AND HUMAN SERVICESInventors: Kenya Johnson, Eric Jacobson, Frank Bedu-Addo, Mikayel Mkrtichyan, Samir N. Khleif
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Patent number: 10702541Abstract: A composition and method for activating immune cells ex-vivo, or inducing an immune response in a subject including a composition comprising at least one chiral cationic lipid. The chiral cationic lipid in one embodiment comprises a nonsteroidal cationic lipid having a structure represented by formula (I); wherein in R1 is a quaternary ammonium group, Y1 is a spacer chosen from a hydrocarbon chain, an ester, a ketone, and a peptide, C* is a chiral carbon, R2 and R3 are independently chosen from a saturated fatty acid, an unsaturated fatty acid, an ester-linked hydrocarbon, phosphor-diesters, and combinations thereof.Type: GrantFiled: September 12, 2017Date of Patent: July 7, 2020Assignee: PDS Biotechnology CorporationInventors: Elizabeth Ann Vasievich, Weihsu Claire Chen, Kenya N. Toney Johnson, Gregory Conn, Frank Bedu-Addo, Leaf Huang
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Patent number: 10286064Abstract: The present disclosure provides vaccine compositions comprising at least one adjuvant and at least one therapeutic factor. The disclosure also provides methods of reducing an immune suppressor cell population in a mammal, methods of augmenting an immune response in a mammal, and methods of treating a disease in a mammal utilizing the vaccine compositions.Type: GrantFiled: June 13, 2013Date of Patent: May 14, 2019Assignees: PDS Biotechnology Corporation, THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SEC. OF THE DEPT. OF HEALTH AND HUMAN SERVICESInventors: Kenya Johnson, Eric Jacobson, Frank Bedu-Addo, Mikayel Mkrtichyan, Samir N. Khleif
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Patent number: 9789129Abstract: Compositions and methods for treating immune cells and activating immune responses are disclosed. The compositions comprise one or more optically active chiral cationic lipids.Type: GrantFiled: April 14, 2009Date of Patent: October 17, 2017Assignee: PDS Biotechnology CorporationInventors: Elizabeth Ann Vasievich, Weihsu Claire Chen, Kenya Toney Johnson, Gregory Conn, Frank Bedu-Addo, Leaf Huang
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Publication number: 20150110823Abstract: The present disclosure provides vaccine formulations comprising at least one peptide antigen assembly and at least one adjuvant. The disclosure also provides methods of inducing an immune response in a mammal and methods of treating a disease in a mammal utilizing the vaccine formulations.Type: ApplicationFiled: September 12, 2012Publication date: April 23, 2015Applicant: PDS BIOTECHNOLOGY CORPORATIONInventors: Frank Bedu-Addo, Gregory Conn, Eric Jacobson, Carol Mercer, Kenya Johnson
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Patent number: 8877206Abstract: The present invention provides compositions and methods for stimulating an immune response using cationic lipids alone or in combination with antigens.Type: GrantFiled: March 17, 2008Date of Patent: November 4, 2014Assignee: PDS Biotechnology CorporationInventors: Weihsu Chen, Weili Yan, Kenya Toney, Gregory Conn, Frank Bedu-Addo, Leaf Huang
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Publication number: 20110110972Abstract: Compositions and methods for treating immune cells and activating immune responses are disclosed. The compositions comprise one or more optically active chiral cationic lipids.Type: ApplicationFiled: April 14, 2009Publication date: May 12, 2011Applicant: PDS BIOTECHNOLOGY CORPORATIONInventors: Elizabeth Ann Vasievich, Weihsu Claire Chen, Kenya Toney Johnson, Gregory Conn, Frank Bedu-addo, Leaf Huang
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Publication number: 20090017057Abstract: The present invention provides compositions and methods for stimulating an immune response using cationic lipids alone or in combination with antigens.Type: ApplicationFiled: March 17, 2008Publication date: January 15, 2009Applicant: PDS BIOTECHNOLOGY CORPORATIONInventors: Weihsu Chen, Weili Yan, Kenya Toney, Gregory Conn, Frank Bedu-Addo, Leaf Huang
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Publication number: 20080131455Abstract: The present invention provides antigen delivery compositions and methods of using same to prevent or to treat cancers and other infectious diseases.Type: ApplicationFiled: November 26, 2007Publication date: June 5, 2008Applicant: PDS BIOTECHNOLOGY CORPORATIONInventors: Leaf Huang, Zhengrong Cui, John Dileo, Su-Ji Han, Dileep P. Vangasseri
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Patent number: 7303881Abstract: The present invention provides antigen delivery compositions and methods of using same to prevent or to treat cancers and other infectious diseases.Type: GrantFiled: May 2, 2005Date of Patent: December 4, 2007Assignee: PDS Biotechnology CorporationInventors: Leaf Huang, Zhengrong Cui, John Dileo, Su-Ji Han, Dileep P. Vangasseri