Patents Assigned to PDS Biotechnology Corporation
  • Patent number: 10828364
    Abstract: The present disclosure provides vaccine compositions comprising at least one adjuvant and at least one therapeutic factor. The disclosure also provides methods of reducing an immune suppressor cell population in a mammal, methods of argumenting an immune response in a mammal, and methods of treating a diseases in a mammal utilizing the vaccine compositions.
    Type: Grant
    Filed: March 28, 2019
    Date of Patent: November 10, 2020
    Assignees: PDS Biotechnology Corporation, THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SEC. OF THE DEPT. OF HEALTH AND HUMAN SERVICES
    Inventors: Kenya Johnson, Eric Jacobson, Frank Bedu-Addo, Mikayel Mkrtichyan, Samir N. Khleif
  • Patent number: 10702541
    Abstract: A composition and method for activating immune cells ex-vivo, or inducing an immune response in a subject including a composition comprising at least one chiral cationic lipid. The chiral cationic lipid in one embodiment comprises a nonsteroidal cationic lipid having a structure represented by formula (I); wherein in R1 is a quaternary ammonium group, Y1 is a spacer chosen from a hydrocarbon chain, an ester, a ketone, and a peptide, C* is a chiral carbon, R2 and R3 are independently chosen from a saturated fatty acid, an unsaturated fatty acid, an ester-linked hydrocarbon, phosphor-diesters, and combinations thereof.
    Type: Grant
    Filed: September 12, 2017
    Date of Patent: July 7, 2020
    Assignee: PDS Biotechnology Corporation
    Inventors: Elizabeth Ann Vasievich, Weihsu Claire Chen, Kenya N. Toney Johnson, Gregory Conn, Frank Bedu-Addo, Leaf Huang
  • Patent number: 10286064
    Abstract: The present disclosure provides vaccine compositions comprising at least one adjuvant and at least one therapeutic factor. The disclosure also provides methods of reducing an immune suppressor cell population in a mammal, methods of augmenting an immune response in a mammal, and methods of treating a disease in a mammal utilizing the vaccine compositions.
    Type: Grant
    Filed: June 13, 2013
    Date of Patent: May 14, 2019
    Assignees: PDS Biotechnology Corporation, THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SEC. OF THE DEPT. OF HEALTH AND HUMAN SERVICES
    Inventors: Kenya Johnson, Eric Jacobson, Frank Bedu-Addo, Mikayel Mkrtichyan, Samir N. Khleif
  • Patent number: 9789129
    Abstract: Compositions and methods for treating immune cells and activating immune responses are disclosed. The compositions comprise one or more optically active chiral cationic lipids.
    Type: Grant
    Filed: April 14, 2009
    Date of Patent: October 17, 2017
    Assignee: PDS Biotechnology Corporation
    Inventors: Elizabeth Ann Vasievich, Weihsu Claire Chen, Kenya Toney Johnson, Gregory Conn, Frank Bedu-Addo, Leaf Huang
  • Publication number: 20150110823
    Abstract: The present disclosure provides vaccine formulations comprising at least one peptide antigen assembly and at least one adjuvant. The disclosure also provides methods of inducing an immune response in a mammal and methods of treating a disease in a mammal utilizing the vaccine formulations.
    Type: Application
    Filed: September 12, 2012
    Publication date: April 23, 2015
    Applicant: PDS BIOTECHNOLOGY CORPORATION
    Inventors: Frank Bedu-Addo, Gregory Conn, Eric Jacobson, Carol Mercer, Kenya Johnson
  • Patent number: 8877206
    Abstract: The present invention provides compositions and methods for stimulating an immune response using cationic lipids alone or in combination with antigens.
    Type: Grant
    Filed: March 17, 2008
    Date of Patent: November 4, 2014
    Assignee: PDS Biotechnology Corporation
    Inventors: Weihsu Chen, Weili Yan, Kenya Toney, Gregory Conn, Frank Bedu-Addo, Leaf Huang
  • Publication number: 20110110972
    Abstract: Compositions and methods for treating immune cells and activating immune responses are disclosed. The compositions comprise one or more optically active chiral cationic lipids.
    Type: Application
    Filed: April 14, 2009
    Publication date: May 12, 2011
    Applicant: PDS BIOTECHNOLOGY CORPORATION
    Inventors: Elizabeth Ann Vasievich, Weihsu Claire Chen, Kenya Toney Johnson, Gregory Conn, Frank Bedu-addo, Leaf Huang
  • Publication number: 20090017057
    Abstract: The present invention provides compositions and methods for stimulating an immune response using cationic lipids alone or in combination with antigens.
    Type: Application
    Filed: March 17, 2008
    Publication date: January 15, 2009
    Applicant: PDS BIOTECHNOLOGY CORPORATION
    Inventors: Weihsu Chen, Weili Yan, Kenya Toney, Gregory Conn, Frank Bedu-Addo, Leaf Huang
  • Publication number: 20080131455
    Abstract: The present invention provides antigen delivery compositions and methods of using same to prevent or to treat cancers and other infectious diseases.
    Type: Application
    Filed: November 26, 2007
    Publication date: June 5, 2008
    Applicant: PDS BIOTECHNOLOGY CORPORATION
    Inventors: Leaf Huang, Zhengrong Cui, John Dileo, Su-Ji Han, Dileep P. Vangasseri
  • Patent number: 7303881
    Abstract: The present invention provides antigen delivery compositions and methods of using same to prevent or to treat cancers and other infectious diseases.
    Type: Grant
    Filed: May 2, 2005
    Date of Patent: December 4, 2007
    Assignee: PDS Biotechnology Corporation
    Inventors: Leaf Huang, Zhengrong Cui, John Dileo, Su-Ji Han, Dileep P. Vangasseri