Abstract: The present disclosure relates to an adenosine diphosphate (ADP)-ribose binding peptide with anti-cancer activity, and specifically, an ADP-ribose binding peptide having a specific amino acid sequence and a modification thereof, a pharmaceutical composition for preventing or treating cancer comprising the same as an active ingredient, and a pharmaceutical composition for anti-cancer adjuvant. The ADP-ribose binding peptide of the present disclosure has an excellent anti-cancer effect by accumulating ADP-ribose in cancer cells to destroy the balance, thus leading to the death of cancer cells, but not being toxic to normal cells, and when administered in combination with other anti-cancer drugs or anti-cancer radiation therapy, has a very good effect as an anti-cancer adjuvant by enhancing the reactivity to the anti-cancer drugs and radiation therapy.

Abstract: The present disclosure relates to an anti-cancer therapy using adenosine diphosphate ribose (ADP-Ribose), and specifically, to a single anti-cancer therapy of ADP-ribose and a combination therapy of ADP-ribose with an anti-cancer drug or radiation, and the like.