Abstract: The invention relates to improved ANTISENSE agents for the treatment of gram-negative bacterial infections. Compounds of the invention utilise an Antibiotic-Assisted Translocation; AAT? platform to improve influx into bacterial cells through enhanced permeability, providing improved intracellular exposure of the ANTISENSE AGENT and superior treatment of the infection.
Type:
Application
Filed:
November 27, 2019
Publication date:
April 7, 2022
Applicant:
Pedanius Therapeutics Limited
Inventors:
Martin Quibell, Timothy Schulz-Utermoehl, Fraser Murray