Abstract: The present invention relates to synthetic peptides having selectively protected amines of untargeted sites and to methods for production thereof and for specifically conjugating PEG to targeted sites of the synthetic peptides using the same. The present invention provides a much higher yield of PEG conjugated peptides in which PEG is specifically combined to amines at targeted sites.
Type:
Grant
Filed:
January 18, 2003
Date of Patent:
February 16, 2010
Assignee:
Pegsphere Co., Ltd.
Inventors:
Sang Deuk Lee, Kang Choon Lee, Dong Hee Na, Yu Seok Youn
Abstract: The present invention relates to synthetic peptides having selectively protected amines of untargeted sites and to methods for production thereof and for specifically conjugating PEG to targeted sites of the synthetic peptides using the same. The present invention provides a much higher yield of PEG conjugated peptides in which PEG is specifically combined to amines at targeted sites.
Type:
Application
Filed:
January 18, 2003
Publication date:
March 23, 2006
Applicant:
PEGSPHERE CO., LTD.
Inventors:
Sang Lee, Kang Choon Lee, Dong Hee Na, Yu Seok Youn