Patents Assigned to PEKING UNIVERSITY THIRD HOSPITAL
-
Publication number: 20230417768Abstract: The invention relates to a method for prognosing ACS in a subject, the method comprising determining plasma MIF and Nt-proBNP (or BNP) concentrations in a sample from the subject, diagnosing ACS when the subject plasma concentrations are greater than a reference MIF and Nt-proBNP (or BNP) plasma concentration, and prognosing the magnitude of ACS from the subject plasma MIF and Nt-proBNP (or BNP) concentrations. Also provided is a method of treating ACS in a subject, a device, a kit, and a cardiac biomarker related to the methods of prognosing ACS.Type: ApplicationFiled: July 24, 2023Publication date: December 28, 2023Applicants: ALFRED HEALTH, PEKING UNIVERSITY THIRD HOSPITALInventors: Anthony Dart, Wei Gao
-
Publication number: 20200264196Abstract: Provided is a method for prognosing ACS in a subject, the method comprising determining plasma MIF and Nt-ProBNP (or BNP) concentrations in a sample from the subject, diagnosing ACS when the subject plasma concentrations are greater than a reference MIF and Nt-proBNP (or BNP) plasma concentration, and prognosing the magnitude of ACS from the subject plasma MIF and Nt-proBNP (or BNP) concentrations. Also provided are a device, a kit and a cardiac biomarker panel related to the methods of prognosing ACS.Type: ApplicationFiled: September 30, 2017Publication date: August 20, 2020Applicants: ALFRED HEALTH, PEKING UNIVERSITY THIRD HOSPITALInventors: ANTHONY DART, Wei GAO
-
Publication number: 20200256878Abstract: The invention relates to a method for prognosing ACS in a subject, the method comprising determining plasma MIF and Nt-proBNP (or BNP) concentrations in a sample from the subject, diagnosing ACS when the subject plasma concentrations are greater than a reference MIF and Nt-proBNP (or BNP) plasma concentration, and prognosing the magnitude of ACS from the subject plasma MIF and Nt-proBNP (or BNP) concentrations. Also provided is a method of treating ACS in a subject, a device, a kit, and a cardiac biomarker related to the methods of prognosing ACS.Type: ApplicationFiled: September 27, 2018Publication date: August 13, 2020Applicants: ALFRED HEALTH, PEKING UNIVERSITY THIRD HOSPITALInventors: Anthony DART, Wei GAO
-
Use of a statin compound as local drug for treating obesity, diabetes, hypertension and hyperlipemia
Patent number: 10632115Abstract: The invention discloses a use of a statin compound in the preparation of local drugs for improving lipid metabolism and treating obesity, hypertension, hyperlipidemia, fatty liver and hyperglycemia; and statin compound local compositions for improving lipid metabolism and treating obesity, hypertension, fatty liver, hyperlipidemia, atherosclerosis, coronary heart disease, apoplexy and other cardiovascular and cerebrovascular diseases, and drug formulation and preparation method thereof.Type: GrantFiled: February 20, 2018Date of Patent: April 28, 2020Assignee: Peking University Third HospitalInventors: Chunli Song, Ning Yang, Yueyi Cui, Yingsheng Yu -
Publication number: 20190161811Abstract: Disclosed in the present invention is a non-invasive detection method for screening for a well-developed blastocyst. A DNA methylation profile of a few of trophoblastic cells in a blastocyst is detected, and the average methylation level and the methylation pattern of embryos identified as having a good morphology in Gardner morphological blastocyst grading process are used as the standard for screening for well-developed blastocysts. The nearer the methylation level of the trophoblastic cells of the blastocyst to be tested approaches the methylation level or state of the good embryo, the better the embryo development is and the higher the suitability for being implanted into a maternal subject is. Furthermore, results of methylation sequencing may be analyzed to determine whether a chromosome is abnormal, so as to directly exclude chromosome-abnormal embryos.Type: ApplicationFiled: April 11, 2017Publication date: May 30, 2019Applicants: Beijing Institute of Genomics, Chinese Academy of Sciences, Peking University Third Hospital, The Third Affiliated Hospital of Guangzhou Medical UniversityInventors: Jiang Liu, Jie Qiao, Guoqiang Li, Yang Yu, Yong Fan, Congru Li
-
Patent number: 10179121Abstract: The invention discloses statins compounds used as local intraosseous application for the treatment of ischemic diseases, in particular, discloses local intraosseous application of statin compounds in the treatment of peripheral ischemic diseases or cardio-cerebrovascular ischemic diseases.Type: GrantFiled: September 1, 2016Date of Patent: January 15, 2019Assignee: Peking University Third HospitalInventors: Chunli Song, Yingsheng Xu, Jie Tan, Qi Guo, Can Liu
-
Publication number: 20180055819Abstract: The invention discloses statins compounds used as local intraosseous application for the treatment of ischemic diseases, in particular, discloses local intraosseous application of statin compounds in the treatment of peripheral ischemic diseases or cardio-cerebrovascular ischemic diseases.Type: ApplicationFiled: September 1, 2016Publication date: March 1, 2018Applicant: Peking University Third HospitalInventors: Chunli Song, Yingsheng Xu, Jie Tan, Qi Guo, Can Liu
-
Patent number: 9895366Abstract: The invention discloses a use of a statin compound in the preparation of local drugs for improving lipid metabolism and treating obesity, hypertension, hyperlipidemia, fatty liver and hyperglycemia; and statin compound local compositions for improving lipid metabolism and treating obesity, hypertension, fatty liver, hyperlipidemia, atherosclerosis, coronary heart disease, apoplexy and other cardiovascular and cerebrovascular diseases, and drug formulation and preparation method thereof.Type: GrantFiled: November 22, 2013Date of Patent: February 20, 2018Assignee: Peking University Third HospitalInventors: Chunli Song, Ning Yang, Yueyi Cui, Yingsheng Xu
-
Publication number: 20160375020Abstract: The invention discloses a use of a statin compound in the preparation of local drugs for improving lipid metabolism and treating obesity, hypertension, hyperlipidemia, fatty liver and hyperglycemia; and statin compound local compositions for improving lipid metabolism and treating obesity, hypertension, fatty liver, hyperlipidemia, atherosclerosis, coronary heart disease, apoplexy and other cardiovascular and cerebrovascular diseases, and drug formulation and preparation method thereof.Type: ApplicationFiled: November 22, 2013Publication date: December 29, 2016Applicant: Peking University Third HospitalInventors: Chunli Song, Ning Yang, Yueyi Cui, Yingsheng Xu
-
Patent number: 9192619Abstract: The present invention provides administration methods for CDPC for treating stroke. CDPC was delivered via ECS at a concentration of 40 mmol/L-60 mmol/L. In a specific embodiment of the present invention, the concentration of CDPC administered is 50 mmol/L, CDPC is delivered at one time, the flow rate of administration is 0.2 ?L/min, the volume of CDPC is 1.33 ?L/mL of brain tissue, and the CDPC is administered in the caudate nucleus. The method can decrease the concentration of CDPC entering the brain and further decrease the dosage while improving efficacy. Thus, the result is improved and the probability of adverse effects due to the drug is reduced.Type: GrantFiled: June 21, 2013Date of Patent: November 24, 2015Assignee: PEKING UNIVERSITY THIRD HOSPITALInventor: Hongbin Han