Patents Assigned to Pel-Freez
  • Recombinant rabbit tissue factor
    Patent number: 5858724
    Abstract: Recombinant rabbit tissue factor is cloned and produced in a bacterial host. This protein, which is relatively insoluble and has several disulfide bonds, requires special modifications in order to express and be purified at commercial levels. By expressing the tissue factor as a fusion protein with a bacterial enzyme, thioredoxin, solubility is increased. Use of a thioredoxin reductase deficient host aids in proper tertiary structure for biological activity.
    Type: Grant
    Filed: July 16, 1996
    Date of Patent: January 12, 1999
    Assignee: Pel-Freez
    Inventors: Robert E. Novy, Jr., Michael J. Domanico, Keith W. Yaeger, Warren Kroeker