Abstract: The present invention relates to a clamping device for insertion through a working channel of an endoscope. The clamping device comprises an elongated housing body having a thumb ring on a first end thereof and a flexible elongated outer sheath attached to a second end of the housing. An inner sheath is slidably arranged within the housing and the outer sheath. A biasable clamp arrangement is connectively disposed on the distal end of the inner sheath. An annular ring is arranged on the distal end of the outer sheath. The biasable clamp arrangement is openable and closable in response to longitudinal movement of the inner sheath with respect to the outer sheath by a camming action between the arms and the annular ring. The arms may be connected to a proper circuit for providing mono-polar or bi-polar energization to tissue clamped between the arms comprising the clamp arrangement.