Abstract: An extended release composition for an analgesic active pharmaceutical ingredient which may be an opioid, preferably hydrocodone as the only active ingredient. The extended release composition preferably comprises a extended release composition which may be in the form of beads contained in an oral dosage form such as gelatin capsules. The composition is designed to release hydrocodone in a way such that the increase in hydrocodone exposure in hepatically impaired patients is not clinically significant. The oral dosage units are supplied as part of a kit, which also includes a primary package and a package insert all sold as a commercially marketed product.
Type:
Grant
Filed:
May 13, 2016
Date of Patent:
September 6, 2016
Assignee:
Pemix Ireland Pain Limited
Inventors:
Andrew Hartman, Christopher M. Rubino, Cynthia Y. Robinson
Abstract: An extended release composition for an analgesic active pharmaceutical ingredient which may be an opioid, preferably hydrocodone as the only active ingredient. The extended release composition preferably comprises a extended release composition which may be in the form of beads contained in an oral dosage form such as gelatin capsules. The composition is designed to release hydrocodone in a way such that the increase in hydrocodone exposure in hepatically impaired patients is not clinically significant. The oral dosage units are supplied as part of a kit, which also includes a primary package and a package insert all sold as a commercially marketed product.
Type:
Grant
Filed:
December 22, 2015
Date of Patent:
May 3, 2016
Assignee:
Pemix Ireland Pain Limited
Inventors:
Andrew Hartman, Christopher M. Rubino, Cynthia Y. Robinson
Abstract: An extended release composition for an analgesic active pharmaceutical ingredient which may be an opioid, preferably hydrocodone as the only active ingredient. The extended release composition preferably comprises a extended release composition which may be in the form of beads contained in an oral dosage form such as gelatin capsules. The composition is designed to release hydrocodone in a way such that the increase in hydrocodone exposure in hepatically impaired patients is not clinically significant. The oral dosage units are supplied as part of a kit, which also includes a primary package and a package insert all sold as a commercially marketed product.
Type:
Grant
Filed:
July 31, 2015
Date of Patent:
February 23, 2016
Assignee:
Pemix Ireland Pain Limited
Inventors:
Andrew Hartman, Christopher M. Rubino, Cynthia Y. Robinson