Patents Assigned to Pence, Inc.
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Patent number: 6478939Abstract: A biosensor apparatus for detecting a binding event between a ligand and receptor. The apparatus includes a biosensor surface and surface-bound two-subunit heterodimer complexes composed of first and second, preferably oppositely charged peptides that together form an &agr;-helical coiled-coil heterodimer. The first peptide is attached to the biosensor surface, and the second peptide carries the ligand, accessible for binding by a ligand-binding agent. Binding of anti-ligand binding agent to the surface-bound ligand is detected by a suitable detector. A ligand-specific biosensor surface can be readily prepared from a universal template containing the first charged peptide, by addition of a selected ligand attached to the second peptide.Type: GrantFiled: May 24, 2000Date of Patent: November 12, 2002Assignees: Pence, Inc., McGill UniversityInventors: R. Bruce Lennox, Robert S. Hodges, Randall T. Irvin
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Patent number: 6461490Abstract: A biosensor apparatus for detecting a binding event between a ligand and receptor. The apparatus includes a biosensor surface and surface-bound two-subunit heterodimer complexes composed of first and second, preferably oppositely charged peptides that together form an &agr;-helical coiled-coil heterodimer. The-first peptide is attached to the biosensor surface, and the second peptide carries the ligand, accessible for binding by a ligand-binding agent. Binding of anti-ligand binding agent to the surface-bound ligand is detected by a suitable detector. A ligand-specific biosensor surface can be readily prepared from a universal template containing the first charged peptide, by addition of a selected ligand attached to the second peptide.Type: GrantFiled: July 27, 2000Date of Patent: October 8, 2002Assignees: PENCE, Inc., McGill UniversityInventors: R. Bruce Lennox, Robert S. Hodges, Randall T. Irvin
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Patent number: 6358921Abstract: The invention concerns antimicrobial cyclic peptides and peptide analogs having relatively low hemolytic activity. Peptides of the invention are effective in killing and/or inhibiting growth of a number of microorganisms, including gram-positive bacteria, gram-negative bacteria, fungi and mycoplasma. Also disclosed are methods for inhibiting or killing such microorganisms, and therapeutic preparations for such inhibiting or killing.Type: GrantFiled: October 10, 1997Date of Patent: March 19, 2002Assignee: Pence, Inc.Inventors: Leslie H. Kondejewski, Robert S. Hodges, David S. Wishart, Robert E. W. Hancock, Ronald N. McElhaney, Elmar J. Prenner, Ruthven N. A. H. Lewis
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Patent number: 5824483Abstract: Combinatorial libraries of different-sequence peptide members is disclosed. The libraries are comprised of stabilized, alpha-helical polypeptides having a similar tertiary structure but different amino acid residues at specific, "variable" positions in the sequence. The polypeptides are stabilized through coiled-coil interactions with other .alpha.-helical polypeptides and/or via intrahelical lactam bridges. Also disclosed are methods for using such libraries to screen for selected macromolecular ligands.Type: GrantFiled: June 16, 1995Date of Patent: October 20, 1998Assignee: Pence Inc.Inventors: Michael E. Houston, Jr., Robert S. Hodges
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Patent number: 5738996Abstract: A combinatorial library composition and method for using the library to construct oligomers effective to bind to a selected ligand is disclosed. The library composition includes at least two sets of ar oligomer libraries, each library set having selected oligomer subunit positions filled by known subunits, and other subunit positions containing permutations of subunits. In the selection method, oligomers from each library set are identified, and a new permutation library formed of subunits corresponding to the highest binding affinity oligomers in each library is screened for binding affinity to the selected ligand.Type: GrantFiled: June 15, 1994Date of Patent: April 14, 1998Assignee: Pence, Inc.Inventors: Robert S. Hodges, Randall T. Irvin, Arne Holm, Wah Y. Wong, Hasmukh B. Sheth, Devon L. Husband
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Patent number: 5641760Abstract: A method of treating Candida albicans infection is disclosed. In one embodiment, for treatment of oral or vaginal infection, the treatment is by topical application of a composition of conjugates that are each composed of a carrier structure and multiple .beta.GalNac(1-4).beta.Gal moieties attached to the structure. In another embodiment, for treatment of systemic infection, the treatment is by parenteral administration of a humanized form of a mouse monoclonal antibody produced by mouse hybridoma cell line Fm16 or cell line PK99H.Type: GrantFiled: June 17, 1994Date of Patent: June 24, 1997Assignee: Pence, Inc.Inventors: Lei Yu, Kok Kheong Lee, Hasmukh B. Sheth, Randall T. Irvin, Robert S. Hodges