Abstract: The present disclosure relates to controlling drug release in cross-linked poly(valerolactone) based matrices. In one aspect, the compounds or pharmaceutically acceptable salts thereof include a poly(valerolactone)-co-poly(allylvalerolactone)-co-polyethylene glycol (PEG) copolymer. In some embodiments, at least a portion of allylvalerolactone residues within the copolymer are crosslinked with a crosslinker. In some embodiments, the compound has a polydispersity index of less than or equal to 1.5. In one aspect, a method is described herein, comprising: (a) polymerizing valerolactone residues, allylvalerolactone, and polyethylene glycol residues in the presence of a non-metal catalyst via a ring opening polymerization to produce a poly(valerolactone)-co-poly(allylvalerolactone)-co-polyethylene glycol copolymer; (b) crosslinking the poly(valerolactone)-co-poly(allylvalerolactone)-co-polyethylene glycol copolymer with a crosslinker; and (c) loading a drug into the crosslinked copolymer.
Type:
Grant
Filed:
January 17, 2020
Date of Patent:
February 20, 2024
Assignees:
Pendant Biosciences, Inc., The Governing Council of the University of Toronto
Inventors:
Timothy Tordella Ruckh, Carl Eric Elmquist, David Michael Stevens, Frantz Le Dévédec, Hilary Boucher, Christine Allen
Abstract: Disclosed are crosslinked particles (e.g., microparticles) that are capable of storing and releasing drugs. The particles can be macroparticles, microparticles, or nanoparticles and can be composed of polyester backbones. The particles can be loaded with a drug. The particles can degrade in vivo to release the drug. The particles can be prepared by crosslinking functionalized polyester backbones and loaded with a given drug. The particles of the present disclosure can be injected with a syringe. In some embodiments, the particles of the present disclosure are administered in connection with a surgery and release the drug after the site of the surgery for a period of 1-6 months.
Type:
Grant
Filed:
February 27, 2019
Date of Patent:
August 30, 2022
Assignees:
Pendant Biosciences, Inc., The Governing Council of the University of Toronto
Inventors:
Frantz Le Devedec, Christine Allen, David M. Stevens, Dean James Rager-Aguiar, Timothy Tordella Ruckh, Carl Eric Elmquist
Abstract: Disclosed are crosslinked particles (e.g., microparticles) that are capable of storing and releasing drugs. The particles can be macroparticles, microparticles, or nanoparticles and can be composed of polyester backbones. The particles can be loaded with a drug. The particles can degrade in vivo to release the drug. The particles can be prepared by crosslinking functionalized polyester backbones and loaded with a given drug. The particles of the present disclosure can be injected with a syringe. In some embodiments, the particles of the present disclosure are administered in connection with a surgery and release the drug after the site of the surgery for a period of 1-6 months.
Type:
Grant
Filed:
October 7, 2016
Date of Patent:
April 16, 2019
Assignee:
PENDANT BIOSCIENCES, INC.
Inventors:
Frantz Le Dévédec, Christine Jane Allen, David M. Stevens, Dean James Rager-Aguiar, Timothy Tordella Ruckh, Carl Eric Elmquist