Patents Assigned to Pendar Technologies, LLC
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Patent number: 11885681Abstract: A compact, portable Raman spectrometer makes fast, sensitive standoff measurements at little to no risk of eye injury or igniting the materials being probed. This spectrometer uses differential Raman spectroscopy and ambient light measurements to measure point-and-shoot Raman signatures of dark or highly fluorescent materials at distances of 1 cm to 10 m or more. It scans the Raman pump beam(s) across the sample to reduce the risk of unduly heating or igniting the sample. Beam scanning also transforms the spectrometer into an instrument with a lower effective safety classification, reducing the risk of eye injury. The spectrometer's long standoff range automatic focusing make it easier to identify chemicals through clear and translucent obstacles, such as flow tubes, windows, and containers. And the spectrometer's components are light and small enough to be packaged in a handheld housing or housing suitable for a small robot to carry.Type: GrantFiled: March 28, 2022Date of Patent: January 30, 2024Assignee: Pendar Technologies, LLCInventors: Daryoosh Vakhshoori, Romain Blanchard, Peili Chen, Masud Azimi, Tobias Mansuripur, Kalyani Krishnamurthy, Arran M. Bibby, Fred R. Huettig, III, Gokhan Ulu, Greg Vander Rhodes
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Publication number: 20230358709Abstract: In quartz-enhanced photoacoustic spectroscopy (QEPAS), an analyte (typically in gas phase) generates a pressure wave in response to incident laser light. A quartz tuning fork (QTF) resonant at the frequency of the pressure wave transduces the pressure wave into an electrical signal. Pulsing the laser briefly reduces the amount of thermal chirp and increases the fraction of time that the laser emits at the wavelength(s) of interest. This increases the measurement efficiency. Pulsing the incident laser light with bursts of short pulses at the QTF resonant frequency increases signal strength. Exciting the sample with a two pulses at different laser wavelengths, separated by a half QTF period yields signal and background acoustic waves that partially cancel when integrated by the QTF, producing a differential measurement. Pulsing the incident laser light at a frequency faster than the gas response cut off frequency can improve the noise performance of a QEPAS measurement.Type: ApplicationFiled: July 17, 2023Publication date: November 9, 2023Applicant: Pendar Technologies, LLCInventors: Romain BLANCHARD, Daryoosh VAKHSHOORI
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Patent number: 11717167Abstract: The inventors have developed tools for quantifying the mitochondrial redox state of in vivo, in situ tissue using resonance Raman spectroscopy. The tissue is illuminated with an excitation beam that causes the tissue to scatter Raman-shifted light, which is collected and analyzed to produce coefficients representing the relative concentrations of different chromophores in the tissue. These relative concentrations indicate the redox state of whole mitochondria, hemoglobin oxygen saturation, myoglobin oxygen saturation, and/or redox state of individual cytochrome complexes in mitochondria of the in vivo, in situ tissue. Quantifiable information about these states and/or saturations can be used to assess tissue health, including organ (dys)function before, during, and after surgery. For example, this information can be used to predict impending cardiac failure, to guide surgical interventions, to monitor organ health after transplantation, or to guide post-operative care.Type: GrantFiled: March 18, 2020Date of Patent: August 8, 2023Assignees: Pendar Technologies, LLC, Children's Medical Center CorporationInventors: John P. Romfh, Daryoosh Vakhshoori, John N. Kheir, Peili Chen, Brian Polizzotti, Joshua Salvin, Alison Perry
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Publication number: 20230109459Abstract: The present technology includes a system and method for monitoring a donor organ tissue using Raman spectroscopy. The technology enables real-time quantification of the mitochondrial redox state in the tissue sample taken from an organ intended for transplant using a compact device. The system is based on resonance Raman spectroscopy which can quantify a mitochondrial redox state in tissues using a Resonance Raman Reduced Mitochondrial Ratio. The mitochondrial redox state of the tissue sample acts as a marker of tissue function and may distinguish healthy versus damaged tissue. Moreover, these measures may correlate with transplantation outcomes.Type: ApplicationFiled: December 9, 2022Publication date: April 6, 2023Applicants: Pendar Technologies, LLC, The General Hospital CorporationInventors: John P. ROMFH, Daryoosh VAKHSHOORI, Peili CHEN, Shannon Tessier, Reinier De Vries, Stephanie Cronin
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Publication number: 20220373466Abstract: Apparatuses and methods for using Raman Resonance Spectroscopy to evaluate metabolic and oxygenation status of the eye are disclosed herein. In some embodiments, metabolic mapping of the eye may be performed by aligning a Raman spectrum and a recorded spatial image of the eye.Type: ApplicationFiled: October 27, 2020Publication date: November 24, 2022Applicants: Children's Medical Center Corporation, Pendar Technologies, LLCInventors: Lois Smith, Bertan D. Cakir, John Padraic Romfh, Pelli Chen, Daryoosh Vakhshoori
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Publication number: 20220333985Abstract: A compact, portable Raman spectrometer makes fast, sensitive standoff measurements at little to no risk of eye injury or igniting the materials being probed. This spectrometer uses differential Raman spectroscopy and ambient light measurements to measure point-and-shoot Raman signatures of dark or highly fluorescent materials at distances of 1 cm to 10 m or more. It scans the Raman pump beam(s) across the sample to reduce the risk of unduly heating or igniting the sample. Beam scanning also transforms the spectrometer into an instrument with a lower effective safety classification, reducing the risk of eye injury. The spectrometer's long standoff range automatic focusing make it easier to identify chemicals through clear and translucent obstacles, such as flow tubes, windows, and containers. And the spectrometer's components are light and small enough to be packaged in a handheld housing or housing suitable for a small robot to carry.Type: ApplicationFiled: March 28, 2022Publication date: October 20, 2022Applicant: Pendar Technologies, LLCInventors: Daryoosh VAKHSHOORI, Romain BLANCHARD, Peili CHEN, Masud AZIMI, Tobias MANSURIPUR, Kalyani KRISHNAMURTHY, Arran M. BIBBY, Fred R. HUETTIG, III, Gokhan ULU, Greg Vander Rhodes
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Patent number: 11300448Abstract: A compact, portable Raman spectrometer makes fast, sensitive standoff measurements at little to no risk of eye injury or igniting the materials being probed. This spectrometer uses differential Raman spectroscopy and ambient light measurements to measure point-and-shoot Raman signatures of dark or highly fluorescent materials at distances of 1 cm to 10 m or more. It scans the Raman pump beam(s) across the sample to reduce the risk of unduly heating or igniting the sample. Beam scanning also transforms the spectrometer into an instrument with a lower effective safety classification, reducing the risk of eye injury. The spectrometer's long standoff range automatic focusing make it easier to identify chemicals through clear and translucent obstacles, such as flow tubes, windows, and containers. And the spectrometer's components are light and small enough to be packaged in a handheld housing or housing suitable for a small robot to carry.Type: GrantFiled: December 22, 2020Date of Patent: April 12, 2022Assignee: Pendar Technologies, LLCInventors: Daryoosh Vakhshoori, Romain Blanchard, Peili Chen, Masud Azimi, Tobias Mansuripur, Kalyani Krishnamurthy, Arran M. Bibby, Fred R. Huettig, III, Gokhan Ulu, Greg Vander Rhodes
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Patent number: 10921187Abstract: A compact, portable Raman spectrometer makes fast, sensitive standoff measurements at little to no risk of eye injury or igniting the materials being probed. This spectrometer uses differential Raman spectroscopy and ambient light measurements to measure point-and-shoot Raman signatures of dark or highly fluorescent materials at distances of 1 cm to 10 m or more. It scans the Raman pump beam(s) across the sample to reduce the risk of unduly heating or igniting the sample. Beam scanning also transforms the spectrometer into an instrument with a lower effective safety classification, reducing the risk of eye injury. The spectrometer's long standoff range automatic focusing make it easier to identify chemicals through clear and translucent obstacles, such as flow tubes, windows, and containers. And the spectrometer's components are light and small enough to be packaged in a handheld housing or housing suitable for a small robot to carry.Type: GrantFiled: March 12, 2019Date of Patent: February 16, 2021Assignee: Pendar Technologies, LLCInventors: Daryoosh Vakhshoori, Romain Blanchard, Peili Chen, Masud Azimi, Tobias Mansuripur, Kalyani Krishnamurthy, Arran M. Bibby, Fred R. Huettig, III, Gokhan Ulu, Greg Vander Rhodes
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Patent number: 10908129Abstract: In quartz-enhanced photoacoustic spectroscopy (QEPAS), an analyte (typically in gas phase) generates a pressure wave in response to incident laser light. A quartz tuning fork (QTF) resonant at the frequency of the pressure wave transduces the pressure wave into an electrical signal. Pulsing the laser briefly reduces the amount of thermal chirp and increases the fraction of time that the laser emits at the wavelength(s) of interest. This increases the measurement efficiency. Pulsing the incident laser light with bursts of short pulses at the QTF resonant frequency increases signal strength. Exciting the sample with a two pulses at different laser wavelengths, separated by a half QTF period yields signal and background acoustic waves that partially cancel when integrated by the QTF, producing a differential measurement. Pulsing the incident laser light at a frequency faster than the gas response cut off frequency can improve the noise performance of a QEPAS measurement.Type: GrantFiled: December 13, 2017Date of Patent: February 2, 2021Assignee: Pendar Technologies, LLCInventors: Romain Blanchard, Daryoosh Vakhshoori
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Patent number: 10527495Abstract: A compact, portable Raman spectrometer makes fast, sensitive standoff measurements at little to no risk of eye injury or igniting the materials being probed. This spectrometer uses differential Raman spectroscopy and ambient light measurements to measure point-and-shoot Raman signatures of dark or highly fluorescent materials at distances of 1 cm to 10 m or more. It scans the Raman pump beam(s) across the sample to reduce the risk of unduly heating or igniting the sample. Beam scanning also transforms the spectrometer into an instrument with a lower effective safety classification, reducing the risk of eye injury. The spectrometer's long standoff range automatic focusing make it easier to identify chemicals through clear and translucent obstacles, such as flow tubes, windows, and containers. And the spectrometer's components are light and small enough to be packaged in a handheld housing or housing suitable for a small robot to carry.Type: GrantFiled: March 12, 2019Date of Patent: January 7, 2020Assignee: Pendar Technologies, LLCInventors: Daryoosh Vakhshoori, Romain Blanchard, Peili Chen, Masud Azimi, Tobias Mansuripur, Kalyani Krishnamurthy, Arran M. Bibby, Fred R. Huettig, III, Gokhan Ulu, Greg Vander Rhodes
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Publication number: 20190368927Abstract: A compact, portable Raman spectrometer makes fast, sensitive standoff measurements at little to no risk of eye injury or igniting the materials being probed. This spectrometer uses differential Raman spectroscopy and ambient light measurements to measure point-and-shoot Raman signatures of dark or highly fluorescent materials at distances of 1 cm to 10 m or more. It scans the Raman pump beam(s) across the sample to reduce the risk of unduly heating or igniting the sample. Beam scanning also transforms the spectrometer into an instrument with a lower effective safety classification, reducing the risk of eye injury. The spectrometer's long standoff range automatic focusing make it easier to identify chemicals through clear and translucent obstacles, such as flow tubes, windows, and containers. And the spectrometer's components are light and small enough to be packaged in a handheld housing or housing suitable for a small robot to carry.Type: ApplicationFiled: March 12, 2019Publication date: December 5, 2019Applicant: Pendar Technologies, LLCInventors: Daryoosh VAKHSHOORI, Romain BLANCHARD, Peili CHEN, Masud AZIMI, Tobias MANSURIPUR, Kalyani KRISHNAMURTHY, Arran M. BIBBY, Fred R. HUETTIG, III, Gokhan ULU, Greg Vander Rhodes
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Publication number: 20190368938Abstract: A compact, portable Raman spectrometer makes fast, sensitive standoff measurements at little to no risk of eye injury or igniting the materials being probed. This spectrometer uses differential Raman spectroscopy and ambient light measurements to measure point-and-shoot Raman signatures of dark or highly fluorescent materials at distances of 1 cm to 10 m or more. It scans the Raman pump beam(s) across the sample to reduce the risk of unduly heating or igniting the sample. Beam scanning also transforms the spectrometer into an instrument with a lower effective safety classification, reducing the risk of eye injury. The spectrometer's long standoff range automatic focusing make it easier to identify chemicals through clear and translucent obstacles, such as flow tubes, windows, and containers. And the spectrometer's components are light and small enough to be packaged in a handheld housing or housing suitable for a small robot to carry.Type: ApplicationFiled: March 12, 2019Publication date: December 5, 2019Applicant: Pendar Technologies, LLCInventors: Daryoosh VAKHSHOORI, Romain BLANCHARD, Peili CHEN, Masud AZIMI, Tobias MANSURIPUR, Kalyani KRISHNAMURTHY, Arran M. BIBBY, Fred R. HUETTIG, III, Gokhan ULU, Greg Vander Rhodes
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Publication number: 20190368937Abstract: A compact, portable Raman spectrometer makes fast, sensitive standoff measurements at little to no risk of eye injury or igniting the materials being probed. This spectrometer uses differential Raman spectroscopy and ambient light measurements to measure point-and-shoot Raman signatures of dark or highly fluorescent materials at distances of 1 cm to 10 m or more. It scans the Raman pump beam(s) across the sample to reduce the risk of unduly heating or igniting the sample. Beam scanning also transforms the spectrometer into an instrument with a lower effective safety classification, reducing the risk of eye injury. The spectrometer's long standoff range automatic focusing make it easier to identify chemicals through clear and translucent obstacles, such as flow tubes, windows, and containers. And the spectrometer's components are light and small enough to be packaged in a handheld housing or housing suitable for a small robot to carry.Type: ApplicationFiled: March 12, 2019Publication date: December 5, 2019Applicant: Pendar Technologies, LLCInventors: Daryoosh VAKHSHOORI, Romain Blanchard, Peili Chen, Masud Azimi, Tobias Mansuripur, Kalyani Krishnamurthy, Arran M. Bibby, Fred R. Huettig, III, Gokhan Ulu, Greg Vander Rhodes
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Publication number: 20190368939Abstract: A compact, portable Raman spectrometer makes fast, sensitive standoff measurements at little to no risk of eye injury or igniting the materials being probed. This spectrometer uses differential Raman spectroscopy and ambient light measurements to measure point-and-shoot Raman signatures of dark or highly fluorescent materials at distances of 1 cm to 10 m or more. It scans the Raman pump beam(s) across the sample to reduce the risk of unduly heating or igniting the sample. Beam scanning also transforms the spectrometer into an instrument with a lower effective safety classification, reducing the risk of eye injury. The spectrometer's long standoff range automatic focusing make it easier to identify chemicals through clear and translucent obstacles, such as flow tubes, windows, and containers. And the spectrometer's components are light and small enough to be packaged in a handheld housing or housing suitable for a small robot to carry.Type: ApplicationFiled: March 12, 2019Publication date: December 5, 2019Applicant: Pendar Technologies, LLCInventors: Daryoosh Vakhshoori, Romain Blanchard, Peili Chen, Masud Azimi, Tobias Mansuripur, Kalyani Krishnamurthy, Arran M. Bibby, Fred R. Huettig, III, Gokhan Ulu, Greg Vander Rhodes
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Patent number: 10488260Abstract: A compact, portable Raman spectrometer makes fast, sensitive standoff measurements at little to no risk of eye injury or igniting the materials being probed. This spectrometer uses differential Raman spectroscopy and ambient light measurements to measure point-and-shoot Raman signatures of dark or highly fluorescent materials at distances of 1 cm to 10 m or more. It scans the Raman pump beam(s) across the sample to reduce the risk of unduly heating or igniting the sample. Beam scanning also transforms the spectrometer into an instrument with a lower effective safety classification, reducing the risk of eye injury. The spectrometer's long standoff range automatic focusing make it easier to identify chemicals through clear and translucent obstacles, such as flow tubes, windows, and containers. And the spectrometer's components are light and small enough to be packaged in a handheld housing or housing suitable for a small robot to carry.Type: GrantFiled: March 12, 2019Date of Patent: November 26, 2019Assignee: Pendar Technologies, LLCInventors: Daryoosh Vakhshoori, Romain Blanchard, Peili Chen, Masud Azimi, Tobias Mansuripur, Kalyani Krishnamurthy, Arran M. Bibby, Fred R. Huettig, III, Gokhan Ulu, Greg Vander Rhodes
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Patent number: 10488252Abstract: A compact, portable Raman spectrometer makes fast, sensitive standoff measurements at little to no risk of eye injury or igniting the materials being probed. This spectrometer uses differential Raman spectroscopy and ambient light measurements to measure point-and-shoot Raman signatures of dark or highly fluorescent materials at distances of 1 cm to 10 m or more. It scans the Raman pump beam(s) across the sample to reduce the risk of unduly heating or igniting the sample. Beam scanning also transforms the spectrometer into an instrument with a lower effective safety classification, reducing the risk of eye injury. The spectrometer's long standoff range automatic focusing make it easier to identify chemicals through clear and translucent obstacles, such as flow tubes, windows, and containers. And the spectrometer's components are light and small enough to be packaged in a handheld housing or housing suitable for a small robot to carry.Type: GrantFiled: March 12, 2019Date of Patent: November 26, 2019Assignee: Pendar Technologies, LLCInventors: Daryoosh Vakhshoori, Romain Blanchard, Peili Chen, Masud Azimi, Tobias Mansuripur, Kalyani Krishnamurthy, Arran M. Bibby, Fred R. Huettig, III, Gokhan Ulu, Greg Vander Rhodes
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Patent number: 10451546Abstract: We present here systems and methods for generating a heterodyne signal using the naturally occurring chirp of a pulsed single-mode laser. The electrical square-wave pulse used to drive the laser heats the laser cavity, causing the laser frequency to change or chirp during the emission of the optical pulse. This chirped optical pulse can be split into a chirped signal pulse that interacts with a sample and a chirped reference pulse that interferes with the chirped signal pulse on a detector to produce a heterodyne modulation whose instantaneous phase and amplitude depend on the sample's dispersion and absorption, respectively. The chirp is reproducible, so the heterodyne modulation, instantaneous phase, and/or instantaneous amplitude can be average over many measurements, either with multiple pulses from the same laser or multiple pulses from different lasers, each emitting at a different wavelength.Type: GrantFiled: August 30, 2018Date of Patent: October 22, 2019Assignee: Pendar Technologies, LLCInventors: Daryoosh Vakhshoori, Romain Blanchard, Tobias Mansuripur
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Patent number: 10067055Abstract: We present here systems and methods for generating a heterodyne signal using the naturally occurring chirp of a pulsed single-mode laser. The electrical square-wave pulse used to drive the laser heats the laser cavity, causing the laser frequency to change or chirp during the emission of the optical pulse. This chirped optical pulse can be split into a chirped signal pulse that interacts with a sample and a chirped reference pulse that interferes with the chirped signal pulse on a detector to produce a heterodyne modulation whose instantaneous phase and amplitude depend on the sample's dispersion and absorption, respectively. The chirp is reproducible, so the heterodyne modulation, instantaneous phase, and/or instantaneous amplitude can be average over many measurements, either with multiple pulses from the same laser or multiple pulses from different lasers, each emitting at a different wavelength.Type: GrantFiled: May 11, 2017Date of Patent: September 4, 2018Assignee: PENDAR TECHNOLOGIES, LLCInventors: Daryoosh Vakhshoori, Romain Blanchard, Tobias Mansuripur
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Patent number: 9784620Abstract: A spectroscopy system includes an array of quantum cascade lasers (QCLs) that emits an array of non-coincident laser beams. A lens array coupled to the QCL array substantially collimates the laser beams, which propagate along parallel optical axes towards a sample. The beams remain substantially collimated over the lens array's working distance, but may diverge when propagating over longer distances. The collimated, parallel beams may be directed to/through the sample, which may be within a sample cell, flow cell, multipass spectroscopic absorption cell, or other suitable holder. Alternatively, the beams may be focused to a point on, near, or within the target using a telescope or other suitable optical element(s). When focused, however, the beams remain non-coincident; they simply intersect at the focal point.Type: GrantFiled: December 31, 2015Date of Patent: October 10, 2017Assignee: Pendar Technologies, LLCInventors: Mark F. Witinski, Laurent Diehl, Christian Pfluegl
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Patent number: 9735549Abstract: Photonic integrated circuits (PICs) are based on quantum cascade (QC) structures. In embodiment methods and corresponding devices, a QC layer in a wave confinement region of an integrated multi-layer semiconductor structure capable of producing optical gain is depleted of free charge carriers to create a low-loss optical wave confinement region in a portion of the structure. Ion implantation may be used to create energetically deep trap levels to trap free charge carriers. Other embodiments include modifying a region of a passive, depleted QC structure to produce an active region capable of optical gain. Gain or loss may also be modified by partially depleting or enhancing free charge carrier density. QC lasers and amplifiers may be integrated monolithically with each other or with passive waveguides and other passive devices in a self-aligned manner. Embodiments overcome challenges of high cost, complex fabrication, and coupling loss involved with material re-growth methods.Type: GrantFiled: July 27, 2016Date of Patent: August 15, 2017Assignees: Massachusetts Institute of Technology, Pendar Technologies, LLCInventors: Anish K. Goyal, Laurent Diehl, Christian Pfluegl, Christine A. Wang, Mark Francis Witinski