Abstract: Disclosed is a workpiece receptacle, in particular for an ultrasonic welding device, that has a receiving element for receiving a workpiece. The receiving element can be moved in relation to a base element. A bearing device is disposed between the receiving element and the base element for this purpose. The bearing device has spherical surfaces lying opposite one another.
Abstract: The present invention provides phosphoryl choline derivatives of general formula (I), which are suitable to be immobilized on a solid support to provide a separation material of general formula (II), which bind with both high affinity and high specificity to a protein, more specifically to C-reactive protein and anti-phosphoryl choline antibodies. Said separation materials are particularly useful in the extracorporeal removal of C-reactive protein and anti-phosphoryl choline antibodies from a biological fluid of a patient for prophylaxis and/or treatment of immune dysfunctions and cardiovascular diseases. Also provided is a column that comprises the separation material of general formula (II), as well as a device containing the column. Formula (I), wherein variable X is selected from: —SH, —NHR3, —C?CH, —CH?CH2, —N3 and —CHO; the other variables are as defined in the claims: Formula (II), wherein variable “A” represents a solid support. “A” as well as the other variables are defined in detail in the claims.
Type:
Grant
Filed:
June 19, 2015
Date of Patent:
September 4, 2018
Assignee:
Pentracor GmbH
Inventors:
Victor Prisyazhnoy, Stephan Mattecka, Ahmed Sheriff, Roderich Süssmuth
Abstract: Disclosed is a workpiece receptacle, in particular for an ultrasonic welding device, that has a receiving element for receiving a workpiece. The receiving element can be moved in relation to a base element. A bearing device disposed between the receiving element and the base element for this purpose. The bearing device has spherical surfaces lying opposite one another.
Abstract: The invention relates to the use of a citrate solution for affinity-chromatographic removal of C-reactive protein (CRP) from biological fluids, wherein the CRP is affinity-chromatographically removed using (Ca2+-dependent) binding of CRP to a column material functionalized with ?-phosphonooxyalkyl ammonium groups and/or with ?-ammoniumalkoxy-hydroxy-phosphoryloxy groups.
Type:
Grant
Filed:
November 12, 2015
Date of Patent:
May 8, 2018
Assignee:
Pentracor GmbH
Inventors:
Ahmed Sheriff, Birgit Vogt, Stephan Mattecka
Abstract: A compound comprising at least a structural entity which binds secretory phospholipase A2 IIA (sPLA2 IIA) or parts of it and more preferably human sPLA2 IIA and which a.) blocks at least one or more sPLA2 IIA function on cell surfaces or in a solution, preferably blood or other body fluids or from tissues, most preferably in vivo, b.) and/or depletes sPLA2 IIA from a solution, preferably blood or other body fluids or from tissues, most preferably in vivo.