Abstract: A thrombectomy system includes a catheter having a proximal end and a distal end, a valve in fluid communication with the catheter, and a cutting instrument associated with the distal end of the catheter. The cutting instrument may be configured for axial and/or rotational motion. A controller of the system may be configured to detect operational parameters of the cutting instrument. The controller may determine whether the cutting instrument is engaging with occlusive material based on the detected operational parameters. The controller may operate the valve in one or more operating modes to alter a level of pressure in the catheter based on whether the cutting instrument is engaging with the occlusive material.

Abstract: An aspiration thrombectomy system for use with a vacuum source and an aspiration catheter includes an aspiration catheter, connection tubing configured to act as a common conduit for fluid communication between the aspiration catheter and a vacuum source, controllable valves operable to selectively open and close to control fluid flow, pressure sensors associated with the aspiration catheter or the connection tubing, and an automatic controller configured to operate the valves in a first operational state to generate fluid pressure changes, detect pressure levels in the system, wherein changes in the detected pressure levels are correlated with the generated fluid pressure changes, determine system states based on system state scores determined based on the detected pressure levels, the system state scores indicating a measure of occlusion in the aspiration catheter or the connection tubing, and operate the valves in a second operational state based on the determined system states.

Abstract: A method for compensating for a visual impairment in a virtual reality environment, by multiple computer systems associated with a head mounted display, including, rendering an initial image for display in a virtual reality environment, determining a first visual adjustment to the HMD based on an input received by the HMD, the input being associated with a visual impairment of a user of the HMD, determining that the first visual adjustment does not satisfy a threshold measure of compensation for the visual impairment of the user, determining a second visual adjustment to the HMD, and rendering an adjusted image for display in the virtual reality environment based on the first visual adjustment and the second visual adjustment.

Abstract: A dynamic aspiration method including engaging a distal end of an aspiration catheter against an occlusion in a blood vessel, applying a vacuum through an aspiration lumen of the aspiration catheter using a vacuum source coupled to a proximal end of the aspiration lumen by a connecting tube, whereby portions of the occlusion are drawn into the aspiration lumen, through the connecting tube and into a collection receptacle by the vacuum source, sensing flow through the connecting tube, and automatically generating pressure differentials when a clog or restricted flow is detected.

Abstract: An aspiration catheter assembly including an outer catheter having an elongate tubular body and a distal valve at a distal end of the aspiration catheter assembly, and an inner catheter configured to communicate with a vacuum source, the inner catheter being within the outer catheter and including an aspiration lumen for receiving at least a portion of a clot. The distal valve is configured to be opened and closed at the distal end of the aspiration catheter assembly, and the distal end of the aspiration catheter assembly is configured as a separator such that the portion of the clot can be separated at the distal end and drawn into the aspiration catheter assembly.

Abstract: Automatic synchronization of a magnetic field transmitter and receiver is performed to resolve phase ambiguity so that phase information, used in determining the position and orientation of the receiver, may be derived and maintained. Inertial measurement unit (IMU) information is used to infer gravity-relative orientations of the transmitter and receiver, which are then used as constraints in the synchronization process to determine the position and orientation of the receiver from all four possible solutions or variations. The variation that best conforms to the IMU orientations is chosen as the sync candidate.

Abstract: An aspiration thrombectomy system includes an aspiration catheter configured to accommodate fluid and having a proximal end and a distal end. The system includes connection tubing coupled to the aspiration catheter and configured to act as a common conduit for fluid communication. The system further includes controllable valves operable to control a level of pressure, and pressure sensors positioned downstream from the distal end of the aspiration catheter. A controller is configured to detect and identify pressure levels associated with an open flow state of the aspiration thrombectomy system, and to determine a vascular pressure level of the patient.

Abstract: An aspiration thrombectomy system includes an aspiration catheter configured to accommodate fluid and having a proximal end and a distal end. The system includes connection tubing coupled to the aspiration catheter and configured to act as a common conduit for fluid communication. The system further includes controllable valves operable to control a level of pressure, and pressure sensors positioned downstream from the distal end of the aspiration catheter. A controller is configured to determine a vascular pressure level of the patient, and to determine one or more therapeutic-benefit metrics associated with continuance of the aspiration thrombectomy procedure.

Abstract: An aspiration thrombectomy system including an aspiration catheter having a proximal end and a distal end, the aspiration catheter having a lumen to accommodate fluid, a vacuum source including a controllable vacuum valve, a tubing connected to the aspiration catheter, and a controller configured to detect a change in a catheter diameter corresponding to a change in the connection between the aspiration catheter and the tubing. The controller is configured to change a pulsation protocol associated with the aspiration catheter responsive to the change in the catheter diameter, and the pulsation protocol specifies pressure variations and pressure patterns to modulate the vacuum valve to change a level of vacuum at the distal end of the aspiration catheter.

Abstract: Devices for removing occlusive material from blood lumens and similar physiological structures are provided and generally include a progressive cavity pump. The progressive cavity pump may be integrated into a handle assembly or a distal end of a catheter and may be drive by a motor activated by a controller. In certain implementations, the controller may be configured to activate the motor to generate a pulsatile vacuum using the progressive cavity pump. To facilitate activation of the motor by the controller, the device may further include a pressure sensor configured to measure pressure distal the progressive cavity pump.

Abstract: A method comprises receiving a value corresponding to a height of a subject, and then determining, using processing circuitry, an eye height of the subject based on the height of the subject and on anthropometric data. In some embodiments, the subject may be using a virtual reality application that includes a displayed virtual environment. Based on the determined eye height of the subject, the processing circuitry may cause at least one environmental parameter of the virtual environment to be modified.

Abstract: An aspiration thrombectomy system including an aspiration catheter having a proximal end and a distal end, the aspiration catheter having a lumen to accommodate fluid, a vacuum source including a controllable vacuum valve, a tubing connected to the aspiration catheter, and a controller configured to detect a change in a catheter diameter corresponding to a change in the connection between the aspiration catheter and the tubing. The controller is configured to change a pulsation protocol associated with the aspiration catheter responsive to the change in the catheter diameter, and the pulsation protocol specifies pressure variations and pressure patterns to modulate the vacuum valve to change a level of vacuum at the distal end of the aspiration catheter.

Abstract: A thromboembolic removal system for treating ischemic stroke, including a guide and occlusion catheter, a delivery and aspiration catheter, an aspiration pump, a thromboembolic receiver, and a thromboembolic separator.

Abstract: Venous infusion catheter assemblies and methods of use are described herein. A catheter assembly may comprise an elongated body having a proximal end and a distal end, with an expandable occlusion element disposed on the elongated catheter body. A catheter may include a first infusion lumen extending to a proximal infusion port positioned on the catheter body proximally of the occlusion element and a second infusion lumen extending to a distal infusion port. Some embodiments may use a suction lumen extending to at least one suction port. When the catheter is introduced into vasculature of a patient, the suction port may be positioned in the patient's superior vena cava or right atrium to draw blood, the distal infusion port is positioned to direct normothermic or hyperthermic fluid toward the patient's heart, and the proximal infusion port is positioned to create a flow of hypothermic fluid in the patient's cerebral vasculature.

Abstract: An aspiration thrombectomy system including an aspiration catheter having a proximal end and a distal end, the aspiration catheter having a lumen to accommodate fluid, a vacuum source including a controllable vacuum valve, a tubing connected to the aspiration catheter, and a controller configured to detect a change in a catheter diameter corresponding to a change in the connection between the aspiration catheter and the tubing. The controller is configured to change a pulsation protocol associated with the aspiration catheter responsive to the change in the catheter diameter, and the pulsation protocol specifies pressure variations and pressure patterns to modulate the vacuum valve to change a level of vacuum at the distal end of the aspiration catheter.

Abstract: A system and method for facilitating physical therapy that may include a wearable display, wearable sensors disposed at varying positions on a user, a processor comprising executable instructions configured to provide a virtual reality environment, virtual characters, and therapeutic activities on the wearable display, wherein the virtual characters interact with the user to provide at least form feedback and positive reinforcement. A new instance of the virtual reality environment, with identifiable differences, may be generated in response to a measured completion or partial completion of a therapeutic activity. Changes in the virtual reality environment may offer users continued indications of progression throughout the duration of a physical therapy program.

Abstract: An aspiration thrombectomy system including an aspiration catheter having a proximal end and a distal end, the aspiration catheter having a lumen to accommodate fluid, a vacuum source including a controllable vacuum valve, a tubing connected to the aspiration catheter, and a controller configured to detect a change in a catheter diameter corresponding to a change in the connection between the aspiration catheter and the tubing. The controller is configured to change a pulsation protocol associated with the aspiration catheter responsive to the change in the catheter diameter, and the pulsation protocol specifies pressure variations and pressure patterns to modulate the vacuum valve to change a level of vacuum at the distal end of the aspiration catheter.

Abstract: Real-time two-way communication between a user immersed in a virtual reality (VR) environment and another party who is not in the VR environment. The sequence of video frames being presented to the VR user on, e.g., a head mounted display, i.e., the VR user's “field of view” in the VR environment, is shown to a guest user on their computing device. Simultaneously, video from a camera in a guest user computing device is shown to the VR user in a window in the VR environment. Audio is also exchanged in real time between the VR user and guest user by use of a microphone and loudspeaker in both the VR system and the guest user computing device. The VR user's system can also support both rotational and translational user movement thus properly changing the VR user's apparent distance from objects displayed in the VR environment.

Abstract: A device for removing material from a patient includes a catheter having a distal catheter end and defining a catheter lumen and a containing element coupled to the catheter. The containing element is deployable from the distal catheter end of the catheter and includes an outer wall portion. The outer wall portion includes an inner layer defining an inner chamber and an outer layer coupled to the inner layer. The inner layer and the outer layer form a distal folded edge defining a distal opening of the containing element in communication with the inner chamber. Implementations of the device may further include a control element extending through the catheter lumen and coupled to the containing element for selectively collapsing the inner chamber, a membrane for restricting flow through the outer wall portion, and/or a flow restriction formed by the containing element.

Abstract: A method for compensating for a visual impairment in a virtual reality environment, by multiple computer systems associated with a head mounted display, including, rendering an image for display in a virtual reality environment, identifying, based at least in part on an input received by the head mounted display, a visual impairment associated with a user of the head mounted display, determining one or more visual adjustments to the head mounted display based on the identified visual impairment, and rendering an adjusted image for display in the virtual reality environment based on the one or more visual adjustments.