Abstract: An aspiration thrombectomy system includes a vacuum source, a catheter having a proximal end and a distal end, a junction fluidically connected to the proximal end of the catheter, a sensor to detect flow through the proximal end of the catheter or the junction and produce a flow signal, a vacuum valve fluidically connected to the junction and to the vacuum source, and a controller. The controller may receive the flow signal and modulate the vacuum valve based on the signal. The controller may have a sampling state in which the vacuum valve is not held fully open for a period of time and at least one aspiration state in which the vacuum valve is fully open. The controller may idle in the sampling state in response to the signal indicating open flow, and transition to an aspiration state in response to the signal indicating a clot or thrombus.

Abstract: A hemostasis valve for use with catheters in intravascular procedures. The hemostasis valve comprising a sealable fluid channel that bifurcates from a single distal lumen to two proximal lumens. An upper proximal lumen may include a funnel shaped opening to improve aspiration potential. Rotating locking mechanisms are attachable at the ends of the hemostasis valve to interlock coaxial devices or to form seals around coaxial devices. Injection molding may be used to manufacture a hemostasis valve and its components. A mold and core pins may impart external and internal shapes to a molten polymer. Once the polymer has cooled, the molded component is separated from any pins or molds and attached to other molded components to form an assembled hemostasis valve.

Abstract: A sensor-controlled thrombectomy system includes an aspiration catheter, an aspiration pump, a collection canister, aspiration tubing, an external unit separate containing a medial portion of the aspiration tubing, a sensing unit within the external unit, and a controller that can utilize an algorithm to generate pressure pulses in the sensor-controlled thrombectomy system.

Abstract: Systems and methods are presented herein for detecting different engagement conditions of a separator instrument of a system. Processing circuitry is used to establish a baseline of one or more operational parameters for the separator instrument. At least one deviation from the established one or more baseline operational parameters of the separator instrument is identified using the processing circuitry. The processing circuitry is used to determine that the identified at least one deviation corresponds to at least one engagement condition of the separator instrument. An action is caused to be performed based on the determining by the processing circuitry.

Abstract: A dynamic aspiration system includes a vacuum source, an aspiration catheter, a connecting tube, controllable valves to control a level of pressure in the aspiration catheter or the connecting tube, pressure sensors to detect pressure readings, and a controller capable of utilizing an artificial neural network (ANN) trained to predict flow state classifications. The controller may receive pressure readings from the sensors, provide the pressure readings as input data for the ANN, classify, via the ANN, a current flow state in the aspiration catheter or the connecting tube based on outputs generated by the ANN, and operate the controllable valves based on the classification of the current flow state. The controller operates the controllable valves in a first pressure protocol if the classification by the ANN is restricted or obstructed, and operates the controllable valves in a second pressure protocol if the classification by the ANN is unrestricted.

Abstract: A blood clot removal system including an aspiration catheter, an external unit having a first pressure sensor, a base unit having a second pressure sensor, a vacuum source connected to the base unit, connection tubing connecting the external unit to the aspiration catheter and the base unit, controllable sensory indicators, and a controller to receive a first pressure from the first pressure sensor and a second pressure from the second pressure sensor, determine a pressure differential based on the first pressure and the second pressure, determine a current catheter state from a plurality of catheter states based on the pressure differential, and transmit, via the one or more sensory indicators, one or more sensory indications of the current catheter state.

Abstract: An aspiration thrombectomy system including an aspiration catheter having a proximal portion, a distal end and a lumen extending through the catheter, a vacuum source fluidically coupled to the catheter, a vacuum valve connected between the vacuum source and the proximal portion of the catheter to control a vacuum flow in the catheter lumen, a vent valve fluidically coupled to the proximal portion of the catheter, the vent valve being configured to control a flow of a vent fluid in the catheter lumen, and a controller configured to open and close the vacuum valve and the vent valve in a predetermined cycle to change a level of vacuum at the distal end of the catheter and to control fluid flow in and out from the distal end of the catheter.

Abstract: A platform of computing systems is configured to receive thrombectomy procedure data that is associated with a user of an aspiration thrombectomy system. The procedure data includes sets of temporal datapoints associated with a thrombectomy procedure. The platform of computing systems is further configured to generate thrombectomy analytics data based on baseline procedure data and the sets of datapoints. The platform of computing systems is further configured to visually display the thrombectomy analytics data, and to provide comparative data metrics for selection on an interactive interface.

Abstract: An aspiration thrombectomy system for use with an aspiration catheter, connection tubing to place a vacuum source and the aspiration catheter in fluid communication, controllable valves to control a level of negative pressure provided by the vacuum source, ultrasonic sensors to detect ultrasonic energy in the aspiration catheter or the connection tubing, and an automated controller to generate, via the controllable valves, while the system is operated in a first operational state, a pressure wave in the aspiration catheter or the connection tubing, detect, via the ultrasonic sensors, ultrasonic energy in the aspiration catheter or the connection tubing based on ultrasonic energy originating from the ultrasonic sensors, determine, based at least in part on the generated pressure wave and the detected ultrasonic energy, a system state in the aspiration catheter or the connecting tubing, and operate, based on the determined system state, the system in a second operational state.

Abstract: In one embodiment, an aspiration thrombectomy system includes an aspiration catheter having a proximal end, a distal end, and a lumen to accommodate fluid, a first valve capable of removing fluids from the system to alter a level of pressure in the system in a first manner, a second valve capable of providing fluids into the system to alter the level of pressure in the system in a second manner, and a cutting instrument at the distal end of the aspiration catheter having a spiral body connected to a rounded element having a scooped-out portion for engaging a target occlusive material, the cutting instrument being capable of axial and rotational motion, and the system being capable of cutting and removing the occlusive material based on the motions of the cutting instrument and one or more of the first manner and the second manner of altering the level of pressure.

Abstract: A dynamic aspiration system includes a connecting tube, a vacuum source, a pressure source, an aspiration catheter, a first controllable valve to control a level of negative pressure provided by the vacuum source, a second controllable valve to control a level of positive pressure provided by the pressure source, pressure sensors, and a controller. The controller modulates the controllable valves to generate pressure pulses, determines, for each of the pressure pulses, a degree of success corresponding to a change in a flow in the aspiration catheter or the connecting tube responsive to the pressure pulse, identifies one or more first pressure pulses determined to have the highest degrees of success, and modulates the controllable valves to generate the first pressure pulses in one or more pressure pulse cycles.

Abstract: A vacuum aspiration control system for use with a vacuum source and an aspiration catheter includes a connection tubing configured to act as a fluid conduit between the vacuum source and the aspiration catheter. A controllable valve is configured to control a level of vacuum in the connection tubing provided by the vacuum source, and one or more pressure sensors are associated with the connection tubing. A controller is configured to periodically sample flow when the current flow state is unrestricted, utilize an artificial neural network to classify a flow state for the sampled flow, close the controllable valve if the flow state for the sampled flow is classified as unrestricted, and hold the controllable valve open if the flow state for the sampled flow is classified as restricted or obstructed.

Abstract: In one embodiment, an aspiration thrombectomy system includes an aspiration catheter having a proximal end, a distal end, and a lumen to accommodate fluid, a first valve capable of removing fluids from the system to alter a level of pressure in the system in a first manner, a second valve capable of providing fluids into the system to alter the level of pressure in the system in a second manner, and a cutting instrument at the distal end of the aspiration catheter having a spiral body connected to a rounded element having a scooped-out portion for engaging a target occlusive material, the cutting instrument being capable of axial and rotational motion, and the system being capable of cutting and removing the occlusive material based on the motions of the cutting instrument and one or more of the first manner and the second manner of altering the level of pressure.

Abstract: In one embodiment, an aspiration thrombectomy system includes an aspiration catheter having a proximal end, a distal end, and a lumen to accommodate fluid, a first valve capable of removing fluids from the system to alter a level of pressure in the system in a first manner, a second valve capable of providing fluids into the system to alter the level of pressure in the system in a second manner, and a cutting instrument at the distal end of the aspiration catheter having a spiral body connected to a rounded element having a scooped-out portion for engaging a target occlusive material, the cutting instrument being capable of axial and rotational motion, and the system being capable of cutting and removing the occlusive material based on the motions of the cutting instrument and one or more of the first manner and the second manner of altering the level of pressure.

Abstract: A thrombectomy system includes a catheter having a proximal end and a distal end, a valve in fluid communication with the catheter, and a cutting instrument associated with the distal end of the catheter. The cutting instrument may be configured for axial and/or rotational motion. A controller of the system may be configured to detect operational parameters of the cutting instrument. The controller may determine whether the cutting instrument is engaging with occlusive material based on the detected operational parameters. The controller may operate the valve in one or more operating modes to alter a level of pressure in the catheter based on whether the cutting instrument is engaging with the occlusive material.

Abstract: An aspiration thrombectomy system for use with a vacuum source and an aspiration catheter includes an aspiration catheter, connection tubing configured to act as a common conduit for fluid communication between the aspiration catheter and a vacuum source, controllable valves operable to selectively open and close to control fluid flow, pressure sensors associated with the aspiration catheter or the connection tubing, and an automatic controller configured to operate the valves in a first operational state to generate fluid pressure changes, detect pressure levels in the system, wherein changes in the detected pressure levels are correlated with the generated fluid pressure changes, determine system states based on system state scores determined based on the detected pressure levels, the system state scores indicating a measure of occlusion in the aspiration catheter or the connection tubing, and operate the valves in a second operational state based on the determined system states.

Abstract: A method for compensating for a visual impairment in a virtual reality environment, by multiple computer systems associated with a head mounted display, including, rendering an initial image for display in a virtual reality environment, determining a first visual adjustment to the HMD based on an input received by the HMD, the input being associated with a visual impairment of a user of the HMD, determining that the first visual adjustment does not satisfy a threshold measure of compensation for the visual impairment of the user, determining a second visual adjustment to the HMD, and rendering an adjusted image for display in the virtual reality environment based on the first visual adjustment and the second visual adjustment.

Abstract: A dynamic aspiration method including engaging a distal end of an aspiration catheter against an occlusion in a blood vessel, applying a vacuum through an aspiration lumen of the aspiration catheter using a vacuum source coupled to a proximal end of the aspiration lumen by a connecting tube, whereby portions of the occlusion are drawn into the aspiration lumen, through the connecting tube and into a collection receptacle by the vacuum source, sensing flow through the connecting tube, and automatically generating pressure differentials when a clog or restricted flow is detected.

Abstract: An aspiration catheter assembly including an outer catheter having an elongate tubular body and a distal valve at a distal end of the aspiration catheter assembly, and an inner catheter configured to communicate with a vacuum source, the inner catheter being within the outer catheter and including an aspiration lumen for receiving at least a portion of a clot. The distal valve is configured to be opened and closed at the distal end of the aspiration catheter assembly, and the distal end of the aspiration catheter assembly is configured as a separator such that the portion of the clot can be separated at the distal end and drawn into the aspiration catheter assembly.

Abstract: Automatic synchronization of a magnetic field transmitter and receiver is performed to resolve phase ambiguity so that phase information, used in determining the position and orientation of the receiver, may be derived and maintained. Inertial measurement unit (IMU) information is used to infer gravity-relative orientations of the transmitter and receiver, which are then used as constraints in the synchronization process to determine the position and orientation of the receiver from all four possible solutions or variations. The variation that best conforms to the IMU orientations is chosen as the sync candidate.