Abstract: The present invention provides polyunsaturated fatty acid compounds having antimalarial and/or neutrophil stimulatory activity. The polyunsaturated fatty acids contain 18-25 carbons and 1-6 double bonds and are characterized in that they have one or two substitutions selected from the group consisting of &bgr; oxa, &ggr; oxa, &bgr; thia and &ggr; thia. It is also preferred that the polyunsaturated fatty acid compound includes a further substitution selected from the group consisting of hydroxy, hydroperoxy, peroxy, carboxymethyl substitutions or attached to an amino acid.

Abstract: Method of treating or ameliorating symptoms of T-cell mediated disease wherein a composition comprising a therapeutically effective amount of a polyunsaturated fatty acid and a pharmaceutically acceptable carrier is administered to the patient. The polyunsaturated fatty acid contains 18-25 carbon atoms, 1-6 double bonds and has 1 or 2 substitutions selected from &bgr; oxa, &ggr; oxa, &bgr; thia and &ggr; thia, based on the fatty acid acyl carbon atom, or the polyunsaturated fatty acid contains 16-26 carbon atoms, 3-double bonds and is covalently coupled at the carboxylic acid group to an amino acid.

Abstract: The present invention provides peptides capable of stimulating neutrophils. In particular, the peptides prime neutrophils for a respiratory burst following treatment with N-formyl-L-methionyl-L-leucyl-L-phenylalanine. The peptides have an amino acid sequence substantially corresponding to amino acids 54 to 94 of FIG. 1 or a part thereof. These peptides may also be used in the treatment of a subject having depressed neutrophil function.

Abstract: The invention provides polyunsaturated fatty acid compounds having antimalarial and/or neutrophil stimulatory activity, or anti-inflammatory activity. The polyunsaturated fatty acids contain a 16-26 carbon chain, 3-6 double bonds and are covalently coupled at the carboxylic acid group to an amino acid. It is preferred that the fatty acid contains 18-22 carbons and that the amino acid is glycine or aspartic acid. Preferred compounds are .gamma.-linolenic acid-glycine, .alpha.-linolenic acid-glycine, arachidonic acid-aspartic acid, eicosapentaenoic acid-aspartic acid and docosahexaenoic acid-aspartic acid.

Abstract: The present invention provides a method for the treatment or prevention of eczema/dermatitis. This method involves the administration of Peptide T or its derivatives or analogues. Preferred compounds used in the method include: 1) D-Ala-Ser-Thr-Thr-Thr-Asn-Tyr-Thr-NH.sub.2 ; 2) Ala-Ser-thr-thr-Thr-Asn-Tyr-Thr, 3) D-Ala-Ser-Thr-Thr-Thr-Asn-Tyr-Thr, 4) D-Ala-Ala-Ser-Ser-Asn-Tyr-Met; 5) Thr-Asp-Asn-Tyr-Thr, 6) Thr-Thr-Ser-Tyr-Thr, 7) Thr-Thr-Asn-Tyr-Thr, 8) D-Thr-Thr-Tyr-D-Thr, 9) D-Ala-Ser-D-Thr-Thr-D-Thr-Asn-Tyr-D-Thr-NH.sub.2 ; 10) D-Ser-Ser-D-Thr-Thr-D-Thr-Thr-Tyr-D-Thr-NH.sub.2.

Abstract: The present invention provides a method for the treatment or prevention of Crohn's disease and/or ulcerative colitis. The method involves the administration of Peptide T or its derivatives or analogues. Preferred compounds used in the method include:1. D--Ala--Ser--Thr--Thr--Thr--Asn--Tyr--Thr--NH.sub.22. Ala--Ser--Thr--Thr--Thr--Asn--Tyr--Thr3. D--Ala--Ser--Thr--Thr--Thr--Ans--Tyr--Thr4. D--Ala--Ala--Ser--Ser--Ser--Asn--Tyr--Met5. Thr--Asp--Asn--Tyr--Thr6. Thr--Thr--Ser--Tyr--Thr7. Thr--Thr--Asn--Tyr--Thr8. D--Thr--Thr--Tyr--D--Thr9. D--Ala--Ser--D--Thr--Thr--D--Thr--Asn--Tyr--D--Thr--NH.sub.210. D--Ser--Ser--D--Thr--Thr--D--Thr--Thr--Tyr--D--Thr--NH.sub.

Abstract: The present invention provides peptides which have the ability to abrogate TNF toxicity and/or LPS toxicity. The present invention further relates to compositions including these peptides as the active ingredient and methods of anti-inflammatory treatment involving the administration of this composition. The peptides of the present invention are based primarily on residue 1 to 26 of human TNF.

Abstract: The present invention provides a method of stimulating macrophage, neutrophil and/or monocyte function in a subject. The method involves the administration of an effective amount of a free fatty acid having a 18-24 carbon chain length with 2-6 double bonds. Preferred polyunsaturated fatty acids are 20:4(n-6), 20:3(n-6), 20:5(n-3), 22:6(n-3), 19:2(n-6), 18:3.gamma.(n-6), 23:4(n-6) and 24:4(n-6).

Abstract: A method of treating inflammatory bowel disease in patients in need of such treatment by administering an effective amount of: I-A-B-C-D-E-F-G-H-II (General Formula I), wherein A is Ala, Gly, Val, Ser, Thr or absent, B is Ala, Gly, Val, Ser, Thr, or absent, C is Ser, Thr or absent. D is Ser, Thr, Asn, Glu, Arg, IIe, Leu or absent, E is Ser, Thr, Asp or absent, F is Ser, Thr, Asp or absent, G is Tyr or absent, H is Thr, Arg, Gly, Met, Met(O), Cys, Thr, Gly or absent, and I is Cys or absent II is Cys, an amide group, substituted amid group, an ester group or absent. At least one of the amino acids optionally being substituted by a monomeric or polymeric carbohydrate or derivative thereof, such substitution being accomplished through hydroxyl and/or amino and/or amido groups of the amino acids, and wherein the peptide comprises at least 4 amino acid residues, and a pharmaceutically acceptable salt thereof.

Abstract: The present invention provides peptides capable of stimulating neutrophils. In particular, the peptides prime neutrophils for a respiratory burst following treatment with N-formyl-L-methionyl-L-leucyl-Lphenylalanine. The peptides have an amino acid sequence substantially corresponding to amino acids 54 to 94 of FIG. 1 or a part thereof. These peptides may also be used in the treatment of a subject having depressed neutrophil function.

Abstract: The present invention provides a method for the treatment of the complications and pathology of diabetes. The method involves the administration to a diabetic subject of a composition comprising a compound selected from the group consisting of (.beta.-Ala-His).sub.n, (Lys-His).sub.n, a compound of the formula R.sub.1 -X-R.sub.2, pharmaceutically acceptable salts thereof and combinations thereof; and a pharmaceutically acceptable carrier, in which n is 2-5, R.sub.1 is one or two naturally occurring amino acids, optionally alpha-amino acetylated with alkyl or aralkyl of 1 to 12 carbon atoms, preferably 2 to 6 carbon atoms, R.sub.2 is 1 or 2 naturally occurring amino acids, optionally alpha-carboxyl esterified or amidated with alkyl or aralkyl of 1 to 12 carbon atoms, preferably 2 to 6 carbon atoms and X is R.sub.3 -L or D-His (R.sub.4)-R.sub.5 where R.sub.3 is void or .omega.-aminoacyl with 1 to 12 carbon atoms, preferably 2 to 6 carbon atoms, R.sub.

Abstract: The disclosed invention relates to a method for controlling the timing of the ovulation of mares using an LHRH agonist, and to a biocompatible implant for use in such a method.