Patents Assigned to PeptiMed, Inc.
  • Anti-tumor compositions and methods
    Patent number: 10111898
    Abstract: Disclosed herein are oligonucleotide sequences that generate innate immunity in cells within tumors upon its delivery into tumors. In certain embodiments, these oligonucleotides are specifically delivered into tumors through nanoparticles displaying targeting peptides that confer specific binding of the nanoparticle to receptors on the surface of tumor cells and allow for uptake of the nanoparticle into the tumor cells.
    Type: Grant
    Filed: June 15, 2015
    Date of Patent: October 30, 2018
    Assignee: PeptiMed, Inc.
    Inventors: Thomas Primiano, Bey-Dih Chang
  • Reagents and methods for treating cancer
    Patent number: 9273316
    Abstract: This invention describes a genetic system for targeting the EVI1 gene in mammalian cells. The EVI1 gene is an oncogenic transcription factor that, when expressed, accelerates cell division and inhibits death of cells. Nucleotide sequences that block the expression of EVI1 and drug delivery systems for them are described. These nucleotide sequences cause a block in cell growth and division and trigger death of mammalian cells, including lung and ovarian cancer cells.
    Type: Grant
    Filed: May 23, 2011
    Date of Patent: March 1, 2016
    Assignee: PeptiMed, Inc.
    Inventors: Thomas Primiano, Lonnie Bookbinder, Bey-Dih Chang, Jeremy Heidel
  • Compositions of a peptide targeting system for treating cancer
    Patent number: 8680045
    Abstract: This invention describes a protein nanoparticle system for targeting siRNA or other drugs into tumors. The basis of the protein system is elastin-like peptides that self-assemble once exposed to the nucleic acid of the siRNA. Specific targeting peptides are fused to the core ELP structure by standard genetic engineering techniques. These targeting peptides confer specific binding of the nanoparticle to receptors on the surface of tumor cells and allow for uptake of the nanoparticle into the tumor cells.
    Type: Grant
    Filed: November 1, 2011
    Date of Patent: March 25, 2014
    Assignee: PeptiMed, Inc.
    Inventors: Thomas Primiano, Bey-Dih Chang, Jeremy Heidel