Patents Assigned to Peptimmune, Inc.
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Publication number: 20110129497Abstract: The instant invention comprises a process of preparing a composition comprising directed sequence polymer (DSP) mixtures that act as epitopes and useful as vaccines, such DSP synthesized according to a set of rules regarding the identity and the frequency of occurrence of amino acids that substitute a base or native amino acid of a known epitope. The resulting composition is a mixture of related peptides for therapeutic use as a vaccine, preferably for infectious agents that are immune evasive.Type: ApplicationFiled: October 16, 2008Publication date: June 2, 2011Applicant: Peptimmune, Inc.Inventors: Dustan Bonnin, Eric Zanelli, Jeff Krieger, Thomas Mathers
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Publication number: 20100316714Abstract: The invention relates to novel methods and kits for treating or preventing disease through the administration of random copolymers comprising amino acids tyrosine (Y), phenylalanine (F), alanine (A), and lysine (K). The invention also relates to the treatment of autoimmune diseases, such as multiple sclerosis, and to the administration of random copolymers in treatment regimen comprising formulations that are administered at intervals greater than 24 hours, or to sustained release formulations which administer the copolymer over a period greater than 24 hours. The invention further relates to methods for conducting a pharmaceutical business comprising manufacturing, licensing, or distributing kits containing or relating to the formulations or dosing regimens of random copolymer described herein.Type: ApplicationFiled: December 14, 2009Publication date: December 16, 2010Applicant: Peptimmune, Inc.Inventors: James Rasmussen, Jianxin Zhang, Sam Baldwin, Eric Zanelli, Bei Yu, Dustan Bonnin, Keith Johnson
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Publication number: 20100080796Abstract: The instant invention comprises a process for the solid phase synthesis of directed epitope peptide mixtures useful in the treatment and diagnosis of protein conformational disorders, such process defined by a set of rules regarding the identity and the frequency of occurrence of amino acids that substitute a base or native amino acid of a known epitope. The resulting composition is a mixture of related peptides for therapeutic use. The invention also pertains to the process of generating antibodies using the directed epitope peptide mixtures as the antigens, and antibodies generated by such process, useful in the treatment and diagnostics of the said protein conformational disorder.Type: ApplicationFiled: April 17, 2009Publication date: April 1, 2010Applicant: Peptimmune, Inc.Inventors: Dustan Bonnin, Eric Zanelli, Thomas Mathers
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Patent number: 7655221Abstract: The invention relates to novel methods and kits for treating or preventing disease through the administration of random copolymers comprising amino acids tyrosine (Y), phenylalanine (F), alanine (A), and lysine (K). The invention also relates to the treatment of autoimmune diseases, such as multiple sclerosis, and to the administration of random copolymers in treatment regimen comprising formulations that are administered at intervals greater than 24 hours, or to sustained release formulations which administer the copolymer over a period greater than 24 hours. The invention further relates to methods for conducting a pharmaceutical business comprising manufacturing, licensing, or distributing kits containing or relating to the formulations or dosing regimens of random copolymer described herein.Type: GrantFiled: November 17, 2005Date of Patent: February 2, 2010Assignee: Peptimmune, Inc.Inventors: James Rasmussen, Jianxin Zhang, Sam Baldwin, Eric Zanelli, Bei Yu, Dustan Bonnin, Keith Johnson
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Publication number: 20090275496Abstract: The instant invention provides methods for the detection and quantitation of complex peptide mixtures in tissue samples and functional readouts of the results of administration of such complex peptide mixtures. The instant invention further provides methods for administering complex peptide mixtures to a subject in need thereof, the dosage regimen and quantity determined based on the above mentioned method for detection and quantitation.Type: ApplicationFiled: December 10, 2008Publication date: November 5, 2009Applicant: Peptimmune, Inc.Inventors: Sam Baldwin, Dustan Bonnin, Keith Johnson, Jeff Krieger, James Rasmussen, Bei Yu, Eric Zanelli, Jianxin Zhang, Kathryn H. Collins, Michelle Genova, Joseph Kovalchin
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Publication number: 20090036653Abstract: The instant invention comprises a process for selecting and manufacturing antibodies useful for therapeutic, prophylactic, diagnostic or research purposes using epitope peptide mixtures synthesized by the solid phase synthesis, such process defined by a set of rules regarding the identity and the frequency of occurrence of amino acids that substitute a base or native amino acid of a known epitope. The resulting antibodies are related to but distinct from antibodies that bind to the known epitope.Type: ApplicationFiled: May 7, 2008Publication date: February 5, 2009Applicant: Peptimmune, Inc.Inventor: Dustan Bonnin
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Publication number: 20080194462Abstract: The present invention provides methods and compositions for treating autoimmune diseases and other unwanted immune reactions comprising administering a copolymer that binds to one or more HLA-DQ molecules and modulates DQ-restricted T cell responses. The copolymers are random copolymers of amino acids and copolymers comprising anchor residues to facilitate binding to the DQ binding pockets.Type: ApplicationFiled: September 15, 2005Publication date: August 14, 2008Applicant: Peptimmune, Inc.Inventors: Kai Wucherpfennig, James Rasmussen, Bei Yu, Eric Zanelli, Jack L. Strominger
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Publication number: 20080146504Abstract: The instant invention comprises a process for the solid phase synthesis of directed epitope peptide mixtures useful in the modulation of unwanted immune responses, such process defined by a set of rules regarding the identity and the frequency of occurrence of amino acids that substitute a base or native amino acid of a known epitope. The resulting composition is a mixture of related peptides for therapeutic use.Type: ApplicationFiled: April 13, 2007Publication date: June 19, 2008Applicant: Peptimmune, Inc.Inventor: Dustan Bonnin
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Patent number: 7084247Abstract: The present invention provides isolated peptides relating to the autoimmune disease pemphigus vulgaris. The peptides relating to pemphigus vulgaris are self epitopes derived from human pathogens which are implicated in the aetiology and remissions of the disease. Pharmaceutical preparations for tolerizing and/or immunizing individuals are provided as well as methods relating thereto. Methods are provided for identifying other self and non-self epitopes involved in human autoimmune disease and similar pharmaceutical preparations and methods of use for these epitopes are also provided.Type: GrantFiled: March 11, 2004Date of Patent: August 1, 2006Assignee: Peptimmune, Inc.Inventors: James Rasmussen, Bei Yu
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Publication number: 20060159672Abstract: The present invention provides isolated peptides relating to the autoimmune disease Pemphigus vulgaris. The peptides relating to Pemphigus vulgaris are self epitopes derived from human pathogens which are implicated in the aetiology and remissions of the disease. Pharmaceutical preparations for tolerizing and/or immunizing individuals are provided as well as methods relating thereto. Methods are provided for identifying other self and non-self epitopes involved in human autoimmune disease and similar pharmaceutical preparations and methods of use for these epitopes are also provided.Type: ApplicationFiled: March 23, 2006Publication date: July 20, 2006Applicant: Peptimmune, Inc.Inventors: James Rasmussen, Bei Yu