Abstract: This disclosure relates to containers (e.g., in the form of bags) comprising a fluoropolymer and containing a degradable carrier comprising biological agent-capturing moieties, to cell isolation systems comprising such containers, and to methods for cultivating a biological agent using such containers. In one embodiment, the disclosure provides a container having an outer surface and an inner surface, the inner surface comprising a fluoropolymer, and contained in the container, a degradable carrier; wherein the carrier comprises a plurality of biological agent-capturing moieties.

Abstract: This disclosure relates generally to containers (such as bags) having surfaces comprising one or more aptamer sequences. More particularly, the present disclosure relates to containers such as bags comprising a fluoropolymer attached to aptamer sequences having binding affinity for one or more biological agents, and to transductions methods using such containers. In one aspect, the disclosure provides a container (e.g., a bag) having an outer surface and an inner surface, the inner surface comprising a fluoropolymer; attached to the fluoropolymer, a plurality of functional groups; and attached to each of at least a portion of the functional groups, a first aptamer sequence having a binding affinity for a viral vector.

Abstract: A cell culture container is provided, comprising membrane bound compartments for growing and harvesting monocytes that allows replenishing and removal of feed media without the loss or death of cells.

Abstract: A liquid recovery filter assembly for recovering filtered liquid trapped within a core or downstream side of a filter element. Multiple embodiments each include a recovery port and a recovery filter in fluid communication with the core or downstream side of the filter element. The recovery port is opened following filtration operations to permit and to facilitate filtered liquid to flow from a downstream or outlet port, thus allowing recovery of liquid remaining in the filter core or downstream side following filtering operations. The recovery filter permits the introduction of pressurized gas to force the filtered liquids from the filter assembly without compromising the sterility and/or non-contaminant condition of the liquid.

Abstract: This disclosure relates to polysiloxanes and polysiloxane compositions having dual-curable properties, to methods for forming articles from such compositions, and to articles formed thereby. In one embodiment, the polysiloxane comprises at least about two alkenyl groups and at least about two (meth)acryloyl groups.

Abstract: A valve including a valve body including an inlet opening and a plurality of outlet openings; and an actuating gate adapted to seal at least one of the plurality of outlet openings, where the actuating gate is adapted to rotate eccentrically about a central axis while also translating in a direction perpendicular to the central axis upon actuation.

Abstract: The disclosure relates generally to a cell culture apparatus and a cell culture method. One aspect of the disclosure provides a perfusion cell culture bag comprising one or more polymer films, having edges bonded together to form edges around an undivided interior compartment of the bag; first and second ports each formed in an exterior surface of the bag; first and second liquid-permeable tubes each extending into and in fluid communication with the interior compartment of the bag and operatively coupled to a respective port; and a third port formed in an exterior surface of the bag, the third port being in fluid communication with the interior compartment of the bag; wherein the first tube comprises a first inner support structure defining a central lumen of the tube and a first outer filter layer surrounding the first inner support structure.

Abstract: The present disclosure relates to methods for preparing a hydrophilic composition including intimately mixing a silicone component including at least one polysiloxane and a polymer component, and to hydrophobic polymer compositions prepared thereby. One aspect of the disclosure provides an article having a major exterior surface, the article comprising an intimate mixture of a silicone component including at least one polysiloxane; and a polymer component including at least one hydrophilic polymer having a water-absorption capacity of at least 50 wt. %; wherein the silicone component and the polymer component are present in the mixture in a dry weight ratio within the range of 99.9:0.1 to 30:70. In certain desirable embodiments as otherwise described herein, the intimate mixture is disposed at an exterior surface of the article, e.g., at the major exterior surface of the article.

Abstract: The present disclosure relates generally to photocurable compositions and methods for continuously forming a three-dimensional body from these compositions. More particularly, the present disclosure relates to photocurable compositions comprising a mixture of polysiloxanes capable of being dually cured, i.e., first by UV radiation followed by thermal treatment, or being cured by UV radiation. In one aspect, the disclosure provides a photocurable composition, including: a first polysiloxane comprising at least two acrylate or methacrylate groups per molecule; a second polysiloxane containing at least one (e.g., at least two) Si—H group per molecule; a third polysiloxane containing at least one (e.g., at least two) reactive aliphatic ethylene group per molecule; a free radical photoinitiator in an amount of about 0.01 to about 10 weight % based on the total weight of (meth)acrylate-containing polysiloxane in the composition; and a hydrosilylation catalyst in an amount of about 0.

Abstract: The invention describes a gas permeable fluoropolymer and silicone material used in the construction of cell culture bags.

Abstract: This disclosure relates to polymerizable silicone compositions, methods for polymerizing such compositions, and to polymerized silicone compositions formed thereby. In one embodiment, a polymerizable composition includes one or more first organosiloxanes or organosilanes, each comprising a plurality of silicon hydride functional groups, one or more second organosiloxanes or organosilanes, each comprising a plurality of reactive heterocycloalkyl functional groups; and one or more third organosiloxanes or organosilanes, each comprising at least about one silicon hydride functional group and at least about one reactive heterocycloalkyl functional group; one or more reactive organic compounds, each comprising at least about one reactive heterocycloalkyl functional group; and an effective amount of a borane catalyst, present, for example, in an amount within the range of 0.

Abstract: The invention describes compositions that include amine-containing silsesquioxane or an amine-containing alkyltrialkoxysilane and a thermoplastic elastomer as well as methods of preparation of the compositions that are useful as self-bonding adhesives for various substrates.

Abstract: This disclosure relates to polymerizable silicone compositions, methods for polymerizing such compositions, and to polymerized silicone compositions formed thereby. In one embodiment, a polymerizable composition includes one or more first organosiloxanes or organosilanes, each comprising a plurality of silicon hydride functional groups, one or more second organosiloxanes or organosilanes, each comprising a plurality of reactive heterocycloalkyl functional groups; and one or more third organosiloxanes or organosilanes, each comprising at least about one silicon hydride functional group and at least about one reactive heterocycloalkyl functional group; and an effective amount of a borane catalyst, present, for example, in an amount within the range of 0.0005 wt % to about 10 wt %, wherein the ratio of reactive heterocycloalkyl functional groups to reactive silicon hydride functional groups in the composition is in the range of 1:5 to 5:1.

Abstract: A liquid recovery filter assembly for recovering filtered liquid trapped within a core or downstream side of a filter element. Multiple embodiments each include a recovery port and a recovery filter in fluid communication with the core or downstream side of the filter element. The recovery port is opened following filtration operations to permit and to facilitate filtered liquid to flow from a downstream or outlet port, thus allowing recovery of liquid remaining in the filter core or downstream side following filtering operations. The recovery filter permits the introduction of pressurized gas to force the filtered liquids from the filter assembly without compromising the sterility and/or non-contaminant condition of the liquid.

Abstract: The present disclosure relates to multi-layered tubings that are fuel resistant and resistant to delamination. In one aspect, the disclosure provides a length of tubing having an annular cross-section including an annular fluoropolymer layer formed from at least 75 wt % fluoropolymer (e.g., at least 75 wt % of a PVDF polymer), the fluoropolymer layer having an outer surface and an inner surface; and disposed about the fluoropolymer layer, an annular thermoplastic layer formed from at least 75 wt % thermoplastic (e.g., thermoplastic polyurethane, thermoplastic polyamide and/or thermoplastic polyester), the thermoplastic polyurethane layer having an inner surface in contact with the outer surface of the fluoropolymer layer and an outer surface, wherein the fluoropolymer layer is covalently bound to the thermoplastic polyurethane layer, for example, by electron beam treatment.

Abstract: The invention describes a gas permeable fluoropolymer and silicone material used in the construction of cell culture bags.

Abstract: The present disclosure relates generally to a layered structure for a radome for use with radiation of a free space frequency. The present disclosure relates more particularly to a layer structure for a radome having a core with an inside surface and an exposed outside surface. The core includes a first core layer having a first relative permittivity of at least 2.3 and a second core layer having a second relative permittivity of at least 2.3. The first core layer is no more than 0.75 mm from the outside surface of the core. An inner structure is disposed on the inside surface of the core and has at least one layer. Each of the first relative permittivity and second relative permittivity is at least 0.4 greater (e.g., at least 0.7 greater, at least 1 greater, or at least 1.3 greater) than a relative permittivity of any layer in the inner structure.

Abstract: The present disclosure relates generally to seal rings useful in oil-lubricated systems such as automobile transmissions, torque converters and automatic clutches. In one embodiment, the disclosure provides an injection molded seal ring comprising a circular ring body extending between a first end and a second end engageable with the first end, the circular ring body including an inner circumferential face; an outer circumferential face; a first lateral face; a second lateral face opposing the first lateral face; a recess formed in the outer circumferential face, the recess not extending to both the first lateral edge and the second lateral edge of the outer circumferential face; and an injection molding gate vestige disposed in the recess, the injection molding gate vestige not extending beyond the outer circumferential face.

Abstract: A cell culture bag is provided, comprising a framed porous inner fluoropolymer bag that allows for growing and harvesting cells and an outer fluoropolymer bag that allows removal and replenishing feed media without loss of cells. In one embodiment, a bag comprising an outer bag and an inner bag is presented. The outer bag comprises a gas permeable porous film having a first port and a second port attached thereto and the inner bag comprises a gas permeable porous film having a third port attached thereto that passes through the outer bag to the inner bag. The inner bag has larger pore size than the outer bag to allow movement of media between the outer bag and the inner bag.

Abstract: The present disclosure relates generally to flexible tubing, for example, suitable for use in peristaltic pumps. The present disclosure relates more particularly to flexible tubing having a stable flow rate despite being extruded from thermoplastic polymer and methods for making such tubing. In one aspect, at least 50% of the material volume of a flexible tubing of the disclosure is formed from a first polymer material that includes a continuous phase that includes polypropylene and a non-cross-linked styrene block copolymer elastomer miscible with the polypropylene, as well as, dispersed within the continuous phase (e.g., discontinuously dispersed within the continuous phase), a cross-linked rubber phase. The non-cross-linked styrene block copolymer elastomer is present in the first polymeric material in an amount in the range of 2 wt % to 15 wt %.