Abstract: Methods, products and kits are provided for attaching agents to a skin surface via microparticles using endogenous or exogenous transglutaminase.
Type:
Application
Filed:
May 10, 2005
Publication date:
May 25, 2006
Applicant:
Pericor Science, Inc.
Inventors:
Howard Green, Bruce Compton, George Corey, Philippe Djian
Abstract: Methods, products and kits are provided for attaching agents to a body tissue surface via microparticles using endogenous or exogenous transglutaminase. The microparticles have surface available transglutaminase substrate reactive groups. In an embodiment, the groups are part of a polymer containing at least two contiguous linked lysines or at least three contiguous linked glutamines.
Type:
Grant
Filed:
July 21, 2000
Date of Patent:
October 25, 2005
Assignee:
Pericor Science, Inc.
Inventors:
Howard Green, Bruce J. Compton, George D. Corey, Philippe Djian
Abstract: Methods, products, compositions and kits are provided for attaching agents to tissue with a linking molecule in the presence of transglutaminase. The linking molecule and/or agent is a substrate of transglutaminase. The agent can be a nonprotein or an enzyme such as cholinesterase or phosphodiesterase. The transglutaminase may be exogenously added or be endogenous in tissue. In specific embodiments, the agent is not a transglutaminase substrate and the linking molecule is a substrate for transglutaminase containing at least two contiguous linked glutamines or at least three contiguous linked lysines, and may be a polymer. A conjugate of the agent and the linking molecule may be applied to tissue, and in the presence of transglutaminase covalently bonded to the tissue via the linking molecule.
Type:
Grant
Filed:
July 22, 1999
Date of Patent:
July 19, 2005
Assignee:
Pericor Science, Inc.
Inventors:
Howard Green, Bruce Compton, George Corey, Philippe Djian