Patents Assigned to Perkin-Elmer
  • Patent number: 11581177
    Abstract: Systems and methods for use in introducing samples to an analytical instrument. The systems and methods are adaptable to process either a liquid sample or a gaseous sample, including samples containing particle contaminants, for subsequent analysis using an analytical instrument.
    Type: Grant
    Filed: July 23, 2019
    Date of Patent: February 14, 2023
    Assignees: PerkinElmer Health Sciences Canada, Inc., Perkin Elmer Yuhan Hoesa
    Inventors: Chady Stephan, Chung Ryu
  • Publication number: 20110287554
    Abstract: Electrospray ionization sources interfaced to mass spectrometers have become widely used tools in analytical applications. Processes occurring in Electrospray (ES) ionization generally include the addition or removal of a charged species such as H+ or other cation to effect ionization of a sample species Electrospray includes ionization processes that occur in the liquid and gas phase and in both phases ionization processes require a source or sink for such charged species. Electrolyte species, that aid in oxidation or reduction reactions occurring in Electrospray ionization, are added to sample solutions in many analytical applications to increase the ion signal amplitude generated in Electrospray and detected by a mass spectrometer (MS). Electrolyte species that may be required to enhance an upstream sample preparation or separation process may be less compatible with the downstream ES processes and cause reduction in MS signal.
    Type: Application
    Filed: April 1, 2011
    Publication date: November 24, 2011
    Applicant: PERKIN ELMER HEALTH SCIENCES, INC.
    Inventors: Craig M. Whitehouse, Thomas White, Shida Shen
  • Patent number: 7816123
    Abstract: Methods and apparatuses for selecting and arranging clinically relevant chromosomal loci allow an exemplary diagnostic array to simultaneously test for numerous genetic alterations that occur in many different parts of the human genome. Clinically irrelevant or ineffective loci are eliminated. One implementation increases reliability and accuracy by dividing the base-pair sequence of each chromosomal locus into segments and then assigning nucleic acid clones for comparative genomic hybridization to each different segment. The segments may overlap for increased resolution and control. Clones representing segments that are adjacent on a native chromosome are placed in non-adjacent target areas of the array to avoid interfering hybridization reactions. Arrangement motifs within an array may be redundantly repeated for high availability and increased reliability and accuracy of results. Techniques, hardware, software, logic engines, loci collections, and diagnostic arrays are described.
    Type: Grant
    Filed: February 11, 2005
    Date of Patent: October 19, 2010
    Assignee: Signature Genomics-Perkin Elmer
    Inventors: Lisa G. Shaffer, Bassem A. Bejjani
  • Publication number: 20100187560
    Abstract: A method for bonding two partially form-fitting surfaces of two metal bodies which contain the same metal is carried out by generating a first layer on the surface of a first one of the two bodies, the first layer containing a mixture of the metal and the oxide of the metal; generating a second layer on the first layer, the second layer containing the metal but less oxide of the metal than does the first layer; placing the partially form-fitting surfaces of the two metal bodies adjacent to each other; heating the bodies placed adjacent to each other to a temperature which lies in a target range below the melting point of the metal and above the eutectic temperature of the eutectic of the metal and the metal oxide; and holding the temperature within the target range over a predetermined or a controllable duration of time.
    Type: Application
    Filed: October 31, 2007
    Publication date: July 29, 2010
    Applicant: PERKIN ELMER OPTOELECTRONICS GMBH & CO. KG
    Inventors: Ulrich Traupe, Stefan Weise, Pellegrino Ballacchino, Edgar Spandl
  • Publication number: 20080285122
    Abstract: An accessory for use with a microscope arranged to carry out ATR measurements has a support (40) which can be mounted on the moveable stage of the microscope. A mounting (100) for an ATR crystal (106) is carried on the support. A sample supporting member (60) is disposed below the location of the ATR crystal. The sample supporting member (60) has a relatively thin upper wall (64). A pressure applying mechanism (80) is located below the wall (64) and is operable to apply pressure to a sample through the wall (64) to ensure good contact between a sample and the sample contacting surface of the crystal.
    Type: Application
    Filed: April 26, 2007
    Publication date: November 20, 2008
    Applicant: Perkin Elmer Singapore PTE Ltd.
    Inventors: Robert Alan Hoult, Ralph Lance Carter, Antonio Canas Wilkinson, Paul Styles
  • Publication number: 20060205953
    Abstract: A radioisotope labeled reagent includes a compound having the general formula (I) where a in each occurrence independently is a carbon mass number between 11 and 14 inclusive, b in each occurrence independently is a hydrogen mass number between 1 and 3 inclusive, such that a in each occurrence is not 12 simultaneously with b in each occurrence being 1; L is a leaving group R1SO2—O—, R1 —S—, 12C1H3(12C1 H2)n—S—R1C(O)O—, NC—, (R1)3P-, XMg- and Li-, where n is an integer between 0 and 3 inclusive, where X is chloro, bromo or iodine, where R1 is H, aryl, a substituent containing aryl, C1-C20 alkyl, a substituent containing C1-C20 alkyl, C2-C20 alkenyl, a substituent containing C2-C20 alkenyl, C2-C20 alkynyl, and a substitute containing C2-C20 alkynyl with the proviso that when n is 0, a is 13 and b is 2 and R1 in R1-S is not aryl.
    Type: Application
    Filed: May 28, 2004
    Publication date: September 14, 2006
    Applicant: Perkin Elmer LAS, Inc.
    Inventor: Jerry Pounds
  • Patent number: 7100925
    Abstract: A pressure-energized, annular metallic seal is provided that includes a central annular portion and a pair of annular leg portions extending from the central portion. Each leg portion includes a convex sealing surface lying in sealing plane. One of the leg portions preferably has an annular flange offset from its sealing plane in an axial direction towards the sealing plane of the other leg portion. One of the leg portions preferably has at least one radially extending tab projecting further than adjacent parts of the seal. The seal is preferably manufactured by first cutting a first annular edge in a metallic sheet material, then bending the sheet material substantially into the shape of the seal, and then cutting a second annular edge to complete the shape of the seal. The second annular edge preferably defines the annular flange and/or the at least one tab.
    Type: Grant
    Filed: July 31, 2003
    Date of Patent: September 5, 2006
    Assignee: Perkin Elmer, Inc.
    Inventors: Jeffrey Swensen, Stephen Rowland
  • Patent number: 6929735
    Abstract: The invention relates to a method and apparatus for providing an electrochemical gas sensor having improved response time for detecting a gas introduced into the sensor. The sensor includes a substrate having a first surface and a second surface and an electrode deposited on the first surface. The sensor also includes an ionomer membrane in contact with the first surface and the electrode. The ionomer membrane has an opening in a location proximate to the electrode for permitting gas introduced into the sensor to diffuse through the opening to simultaneously contact the electrode and the ionomer membrane within the opening. The substrate further includes at least one hole extending from the first surface to the second surface for permitting moisture to diffuse through the at least one hole to contact the ionomer membrane for enhancing sensitivity.
    Type: Grant
    Filed: January 16, 2003
    Date of Patent: August 16, 2005
    Assignee: Perkin Elmer Instruments LLC
    Inventors: Otto J. Prohaska, Avinash Dalmia
  • Patent number: 6891156
    Abstract: A sample plate for mass spectrometric analysis of a specimen is provided comprising a substrate having an electrically conductive surface, a mask applied to the electrically conductive surface. The mask is applied to the substrate with a rough surface to form at least one sample site. The sample site comprises a central portion formed from the electrically conductive surface and a marginal portion formed from the mask where the marginal portion is more hydrophobic than the central portion.
    Type: Grant
    Filed: April 30, 2003
    Date of Patent: May 10, 2005
    Assignee: Perkin Elmer Instruments LLC
    Inventor: Joseph L. DiCesare
  • Patent number: 6682638
    Abstract: A miniaturized gas sensor including film type electrodes, and a solid ionomer electrolyte, for the detection of toxic gases, i.e., carbon monoxide, and other oxidizable or reducible gases and vapors is described. The all-solid planar sensor cell has two or more film type electrodes arranged on a non-conductive planar surface of a supportive material. The electrodes are discrete and in intimate contact with the same solid polymer ionomer membrane. The sensor cell contains no liquid electrolyte and is operated in a potentiostatic or potentiodynamic mode. The unique feature of the sensor cell is that high sensitivity to a select gas or vapor is achieved by a novel three-phase contact area design for a sensing electrode which is easily accessible to the gas sample via small diffusion openings or holes that penetrate through the solid polymer ionomer membrane layer above the sensing electrode.
    Type: Grant
    Filed: November 19, 1999
    Date of Patent: January 27, 2004
    Assignee: Perkin Elmer LLC
    Inventors: Otto J. Prohaska, Anthony B. LaConti, Jose D. Giner, Mourad Manoukian
  • Patent number: 6652625
    Abstract: An analyte pre-concentrator for gas chromatography is disclosed generally comprising a tube having a restricted outlet and packed with an adsorbent, wherein the tube serves as the liner of a chromatographic injector, as an adsorbent trap coupled to a chromatographic column, and/or as an adsorbent trap coupled to a headspace sampler. Preferably, a heating device allows the tube to be heated. In a preferred embodiment, the analyte pre-concentrator further comprises a column isolating accessory so that a chromatographic column can be temporarily isolated from substances flowing through the tube.
    Type: Grant
    Filed: July 24, 2002
    Date of Patent: November 25, 2003
    Assignee: Perkin Elmer Instruments LLC
    Inventors: Andrew Tipler, Gary Campbell, Mark Collins
  • Patent number: 6632401
    Abstract: The present invention relates to a device for the detection of a fluorescent dye in a sample, comprising a radiation source with the aid of which light for exciting the fluorescent dye to be detected can be transmitted into the sample applied to a carrier, and a detecting device for detecting fluorescent light which has been emitted by the fluorescent dye to be detected. The present invention is characterized by a hollow space having an internal high-reflectance surface, a first aperture directed towards the sample, and a second aperture located opposite the detecting device.
    Type: Grant
    Filed: April 6, 1999
    Date of Patent: October 14, 2003
    Assignee: Bodenseewerk Perkin-Elmer GmbH
    Inventor: Jurgen Wulf
  • Publication number: 20030113939
    Abstract: A device for carrying out and/or detecting affinity reactions comprises at least one surface or boundary surface on which an affinity reaction can take place, and at least one polymer bound to the surface. According to the invention, this device is obtainable by bonding the polymer to the surface in its pure phase, i e. essentially free of solvents. The polymer is preferably a terminally homo- or heterosubstituted bifunctional polymer, a corresponding polyalkylene glycol, in particular a polyethylene glycol, being preferred. The surface can be made of a metal oxide, in particular silicon dioxide. Before bonding the polymer, an activation of the surface, preferably by introducing functional groups by means of a silanization, can be effected.
    Type: Application
    Filed: September 6, 2002
    Publication date: June 19, 2003
    Applicant: Bodenseewerk Perkin-Elmer GMBH
    Inventors: Gunter Gauglitz, Andreas Brecht, Jacob Piehler
  • Publication number: 20020164591
    Abstract: The present invention relates to mutant DNA polymerases that exhibit reduced discrimination against labeled nucleotides into polynucleotides. The DNA polymerases of the invention have at least one mutation in the nucleotide label interaction region of the enzyme such the mutation results in reduced discrimination against labeled nucleotides. The nucleotide label interaction regions is located at portions of the O-helix, (ii) the K helix, and (iii) the inter O—P helical loop of Taq DNA polymerase or analogous positions in other DNA polymerases.
    Type: Application
    Filed: February 27, 2001
    Publication date: November 7, 2002
    Applicant: The Perkin-Elmer Corporation
    Inventors: John Brandis, Curtis Bloom, John H. Richards
  • Patent number: 6455267
    Abstract: Isolated polypeptides useful in ameliorating GAD-associated autoimmune disease as well as diagnostic and therapeutic methods of using the peptides are disclosed.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: September 24, 2002
    Assignees: Diamyd Medical AB, RSR Limited, Perkin Elmer Life Sciences
    Inventors: Allan J. Tobin, Mark G. Erlander, Daniel L. Kaufman
  • Patent number: 6448565
    Abstract: The present invention relates to a unit for a plasma atomizer device comprising a supply means for supplying a gas for generating a plasma, an atomizer means for atomizing a sample to be analyzed, an injection means for injecting the atomized sample into a plasma generated with the supplied gas, and a support means for holding the supply means, the atomizer means and the injection means. The invention is characterized in that the support means is connectable to a generator chamber wall of the atomizer device in such a manner that the supply means and the injection means are arranged inside the generator chamber.
    Type: Grant
    Filed: July 13, 2000
    Date of Patent: September 10, 2002
    Assignee: Perkin Elmer Bodenseewerk GmbH
    Inventor: Michael Erath
  • Publication number: 20020115067
    Abstract: A class of asymmetric monobenzoxanthene compounds useful as fluorescent dyes are disclosed having the structure 1
    Type: Application
    Filed: October 11, 2001
    Publication date: August 22, 2002
    Applicant: The Perkin-Elmer Corporation
    Inventors: Scott C. Benson, Steven M. Menchen, Peter D. Theisen, Kevin M. Hennessey, Vergine C. Furniss, Joan D. Hauser
  • Patent number: 6438147
    Abstract: An external cavity laser system composed of a semiconductor diode laser (10), a temperature control (30) and injection current control (40) means the diode laser, an external cavity (60) with a wavelength selector and means for controlling the laser temperature (20), laser injection current and the wavelength selector (110) to obtain arbitrary frequencies within the tuning range of the laser.
    Type: Grant
    Filed: January 26, 1999
    Date of Patent: August 20, 2002
    Assignee: Perkin Elmer Instruments LLC
    Inventors: Chandra Roychoudhuri, David H. Tracy, William J. Hubbard
  • Publication number: 20020094578
    Abstract: Generally, the present invention provides a device and method for accurately locating a multi-well plate at a plate-support location, e.g., a work surface, of an automated laboratory machine, such that one or more acting members of the machine, such as an array of pipette tips, optical sensors, or the like, can accurately address and operate on the individual wells. Interior and/or exterior surface regions of one or more wells of a multi-well plate are used as the primary plate features engaged by locating structure of the machine. In one particular embodiment one or more upwardly tapered projections extend from a plate-support surface of a plate-handling machine for mating engagement with the exterior surface regions of one or more wells. In another embodiment, the exterior surface regions along one or more well bottoms are engagingly received within bores, or other receiving structure, formed on the plate-support surface of a machine.
    Type: Application
    Filed: December 6, 2001
    Publication date: July 18, 2002
    Applicant: The Perkin-Elmer Corporation
    Inventors: Reid Burton Kowallis, David M. Cox
  • Publication number: 20020081616
    Abstract: Long wavelength, narrow emission bandwidth fluorecein dyes are provided for detecting spacially overlapping target substances. The dyes comprise 4,7-dichlorofluoresceins, and particularly 2′,4′,5′,7′-tetrachloro-4,7-dichloro-5- (and 6-) carboxyfluoresceins. Methods and kits for using the dyes in DNA analysis are provided.
    Type: Application
    Filed: September 7, 2001
    Publication date: June 27, 2002
    Applicant: The Perkin-Elmer Corporation
    Inventors: Steven M. Menchen, Linda G. Lee, Charles R. Connell, N. Davis Hershey, Vergine Chakerian, Sam L. Woo, Steven Fung