Patents Assigned to Perkin-Elmer
-
Patent number: 11581177Abstract: Systems and methods for use in introducing samples to an analytical instrument. The systems and methods are adaptable to process either a liquid sample or a gaseous sample, including samples containing particle contaminants, for subsequent analysis using an analytical instrument.Type: GrantFiled: July 23, 2019Date of Patent: February 14, 2023Assignees: PerkinElmer Health Sciences Canada, Inc., Perkin Elmer Yuhan HoesaInventors: Chady Stephan, Chung Ryu
-
Publication number: 20110287554Abstract: Electrospray ionization sources interfaced to mass spectrometers have become widely used tools in analytical applications. Processes occurring in Electrospray (ES) ionization generally include the addition or removal of a charged species such as H+ or other cation to effect ionization of a sample species Electrospray includes ionization processes that occur in the liquid and gas phase and in both phases ionization processes require a source or sink for such charged species. Electrolyte species, that aid in oxidation or reduction reactions occurring in Electrospray ionization, are added to sample solutions in many analytical applications to increase the ion signal amplitude generated in Electrospray and detected by a mass spectrometer (MS). Electrolyte species that may be required to enhance an upstream sample preparation or separation process may be less compatible with the downstream ES processes and cause reduction in MS signal.Type: ApplicationFiled: April 1, 2011Publication date: November 24, 2011Applicant: PERKIN ELMER HEALTH SCIENCES, INC.Inventors: Craig M. Whitehouse, Thomas White, Shida Shen
-
Patent number: 7816123Abstract: Methods and apparatuses for selecting and arranging clinically relevant chromosomal loci allow an exemplary diagnostic array to simultaneously test for numerous genetic alterations that occur in many different parts of the human genome. Clinically irrelevant or ineffective loci are eliminated. One implementation increases reliability and accuracy by dividing the base-pair sequence of each chromosomal locus into segments and then assigning nucleic acid clones for comparative genomic hybridization to each different segment. The segments may overlap for increased resolution and control. Clones representing segments that are adjacent on a native chromosome are placed in non-adjacent target areas of the array to avoid interfering hybridization reactions. Arrangement motifs within an array may be redundantly repeated for high availability and increased reliability and accuracy of results. Techniques, hardware, software, logic engines, loci collections, and diagnostic arrays are described.Type: GrantFiled: February 11, 2005Date of Patent: October 19, 2010Assignee: Signature Genomics-Perkin ElmerInventors: Lisa G. Shaffer, Bassem A. Bejjani
-
Publication number: 20100187560Abstract: A method for bonding two partially form-fitting surfaces of two metal bodies which contain the same metal is carried out by generating a first layer on the surface of a first one of the two bodies, the first layer containing a mixture of the metal and the oxide of the metal; generating a second layer on the first layer, the second layer containing the metal but less oxide of the metal than does the first layer; placing the partially form-fitting surfaces of the two metal bodies adjacent to each other; heating the bodies placed adjacent to each other to a temperature which lies in a target range below the melting point of the metal and above the eutectic temperature of the eutectic of the metal and the metal oxide; and holding the temperature within the target range over a predetermined or a controllable duration of time.Type: ApplicationFiled: October 31, 2007Publication date: July 29, 2010Applicant: PERKIN ELMER OPTOELECTRONICS GMBH & CO. KGInventors: Ulrich Traupe, Stefan Weise, Pellegrino Ballacchino, Edgar Spandl
-
Publication number: 20080285122Abstract: An accessory for use with a microscope arranged to carry out ATR measurements has a support (40) which can be mounted on the moveable stage of the microscope. A mounting (100) for an ATR crystal (106) is carried on the support. A sample supporting member (60) is disposed below the location of the ATR crystal. The sample supporting member (60) has a relatively thin upper wall (64). A pressure applying mechanism (80) is located below the wall (64) and is operable to apply pressure to a sample through the wall (64) to ensure good contact between a sample and the sample contacting surface of the crystal.Type: ApplicationFiled: April 26, 2007Publication date: November 20, 2008Applicant: Perkin Elmer Singapore PTE Ltd.Inventors: Robert Alan Hoult, Ralph Lance Carter, Antonio Canas Wilkinson, Paul Styles
-
Publication number: 20060205953Abstract: A radioisotope labeled reagent includes a compound having the general formula (I) where a in each occurrence independently is a carbon mass number between 11 and 14 inclusive, b in each occurrence independently is a hydrogen mass number between 1 and 3 inclusive, such that a in each occurrence is not 12 simultaneously with b in each occurrence being 1; L is a leaving group R1SO2—O—, R1 —S—, 12C1H3(12C1 H2)n—S—R1C(O)O—, NC—, (R1)3P-, XMg- and Li-, where n is an integer between 0 and 3 inclusive, where X is chloro, bromo or iodine, where R1 is H, aryl, a substituent containing aryl, C1-C20 alkyl, a substituent containing C1-C20 alkyl, C2-C20 alkenyl, a substituent containing C2-C20 alkenyl, C2-C20 alkynyl, and a substitute containing C2-C20 alkynyl with the proviso that when n is 0, a is 13 and b is 2 and R1 in R1-S is not aryl.Type: ApplicationFiled: May 28, 2004Publication date: September 14, 2006Applicant: Perkin Elmer LAS, Inc.Inventor: Jerry Pounds
-
Patent number: 7100925Abstract: A pressure-energized, annular metallic seal is provided that includes a central annular portion and a pair of annular leg portions extending from the central portion. Each leg portion includes a convex sealing surface lying in sealing plane. One of the leg portions preferably has an annular flange offset from its sealing plane in an axial direction towards the sealing plane of the other leg portion. One of the leg portions preferably has at least one radially extending tab projecting further than adjacent parts of the seal. The seal is preferably manufactured by first cutting a first annular edge in a metallic sheet material, then bending the sheet material substantially into the shape of the seal, and then cutting a second annular edge to complete the shape of the seal. The second annular edge preferably defines the annular flange and/or the at least one tab.Type: GrantFiled: July 31, 2003Date of Patent: September 5, 2006Assignee: Perkin Elmer, Inc.Inventors: Jeffrey Swensen, Stephen Rowland
-
Patent number: 6929735Abstract: The invention relates to a method and apparatus for providing an electrochemical gas sensor having improved response time for detecting a gas introduced into the sensor. The sensor includes a substrate having a first surface and a second surface and an electrode deposited on the first surface. The sensor also includes an ionomer membrane in contact with the first surface and the electrode. The ionomer membrane has an opening in a location proximate to the electrode for permitting gas introduced into the sensor to diffuse through the opening to simultaneously contact the electrode and the ionomer membrane within the opening. The substrate further includes at least one hole extending from the first surface to the second surface for permitting moisture to diffuse through the at least one hole to contact the ionomer membrane for enhancing sensitivity.Type: GrantFiled: January 16, 2003Date of Patent: August 16, 2005Assignee: Perkin Elmer Instruments LLCInventors: Otto J. Prohaska, Avinash Dalmia
-
Patent number: 6891156Abstract: A sample plate for mass spectrometric analysis of a specimen is provided comprising a substrate having an electrically conductive surface, a mask applied to the electrically conductive surface. The mask is applied to the substrate with a rough surface to form at least one sample site. The sample site comprises a central portion formed from the electrically conductive surface and a marginal portion formed from the mask where the marginal portion is more hydrophobic than the central portion.Type: GrantFiled: April 30, 2003Date of Patent: May 10, 2005Assignee: Perkin Elmer Instruments LLCInventor: Joseph L. DiCesare
-
Patent number: 6682638Abstract: A miniaturized gas sensor including film type electrodes, and a solid ionomer electrolyte, for the detection of toxic gases, i.e., carbon monoxide, and other oxidizable or reducible gases and vapors is described. The all-solid planar sensor cell has two or more film type electrodes arranged on a non-conductive planar surface of a supportive material. The electrodes are discrete and in intimate contact with the same solid polymer ionomer membrane. The sensor cell contains no liquid electrolyte and is operated in a potentiostatic or potentiodynamic mode. The unique feature of the sensor cell is that high sensitivity to a select gas or vapor is achieved by a novel three-phase contact area design for a sensing electrode which is easily accessible to the gas sample via small diffusion openings or holes that penetrate through the solid polymer ionomer membrane layer above the sensing electrode.Type: GrantFiled: November 19, 1999Date of Patent: January 27, 2004Assignee: Perkin Elmer LLCInventors: Otto J. Prohaska, Anthony B. LaConti, Jose D. Giner, Mourad Manoukian
-
Patent number: 6652625Abstract: An analyte pre-concentrator for gas chromatography is disclosed generally comprising a tube having a restricted outlet and packed with an adsorbent, wherein the tube serves as the liner of a chromatographic injector, as an adsorbent trap coupled to a chromatographic column, and/or as an adsorbent trap coupled to a headspace sampler. Preferably, a heating device allows the tube to be heated. In a preferred embodiment, the analyte pre-concentrator further comprises a column isolating accessory so that a chromatographic column can be temporarily isolated from substances flowing through the tube.Type: GrantFiled: July 24, 2002Date of Patent: November 25, 2003Assignee: Perkin Elmer Instruments LLCInventors: Andrew Tipler, Gary Campbell, Mark Collins
-
Patent number: 6632401Abstract: The present invention relates to a device for the detection of a fluorescent dye in a sample, comprising a radiation source with the aid of which light for exciting the fluorescent dye to be detected can be transmitted into the sample applied to a carrier, and a detecting device for detecting fluorescent light which has been emitted by the fluorescent dye to be detected. The present invention is characterized by a hollow space having an internal high-reflectance surface, a first aperture directed towards the sample, and a second aperture located opposite the detecting device.Type: GrantFiled: April 6, 1999Date of Patent: October 14, 2003Assignee: Bodenseewerk Perkin-Elmer GmbHInventor: Jurgen Wulf
-
Publication number: 20030113939Abstract: A device for carrying out and/or detecting affinity reactions comprises at least one surface or boundary surface on which an affinity reaction can take place, and at least one polymer bound to the surface. According to the invention, this device is obtainable by bonding the polymer to the surface in its pure phase, i e. essentially free of solvents. The polymer is preferably a terminally homo- or heterosubstituted bifunctional polymer, a corresponding polyalkylene glycol, in particular a polyethylene glycol, being preferred. The surface can be made of a metal oxide, in particular silicon dioxide. Before bonding the polymer, an activation of the surface, preferably by introducing functional groups by means of a silanization, can be effected.Type: ApplicationFiled: September 6, 2002Publication date: June 19, 2003Applicant: Bodenseewerk Perkin-Elmer GMBHInventors: Gunter Gauglitz, Andreas Brecht, Jacob Piehler
-
Publication number: 20020164591Abstract: The present invention relates to mutant DNA polymerases that exhibit reduced discrimination against labeled nucleotides into polynucleotides. The DNA polymerases of the invention have at least one mutation in the nucleotide label interaction region of the enzyme such the mutation results in reduced discrimination against labeled nucleotides. The nucleotide label interaction regions is located at portions of the O-helix, (ii) the K helix, and (iii) the inter O—P helical loop of Taq DNA polymerase or analogous positions in other DNA polymerases.Type: ApplicationFiled: February 27, 2001Publication date: November 7, 2002Applicant: The Perkin-Elmer CorporationInventors: John Brandis, Curtis Bloom, John H. Richards
-
Patent number: 6455267Abstract: Isolated polypeptides useful in ameliorating GAD-associated autoimmune disease as well as diagnostic and therapeutic methods of using the peptides are disclosed.Type: GrantFiled: June 7, 1995Date of Patent: September 24, 2002Assignees: Diamyd Medical AB, RSR Limited, Perkin Elmer Life SciencesInventors: Allan J. Tobin, Mark G. Erlander, Daniel L. Kaufman
-
Patent number: 6448565Abstract: The present invention relates to a unit for a plasma atomizer device comprising a supply means for supplying a gas for generating a plasma, an atomizer means for atomizing a sample to be analyzed, an injection means for injecting the atomized sample into a plasma generated with the supplied gas, and a support means for holding the supply means, the atomizer means and the injection means. The invention is characterized in that the support means is connectable to a generator chamber wall of the atomizer device in such a manner that the supply means and the injection means are arranged inside the generator chamber.Type: GrantFiled: July 13, 2000Date of Patent: September 10, 2002Assignee: Perkin Elmer Bodenseewerk GmbHInventor: Michael Erath
-
Publication number: 20020115067Abstract: A class of asymmetric monobenzoxanthene compounds useful as fluorescent dyes are disclosed having the structure 1Type: ApplicationFiled: October 11, 2001Publication date: August 22, 2002Applicant: The Perkin-Elmer CorporationInventors: Scott C. Benson, Steven M. Menchen, Peter D. Theisen, Kevin M. Hennessey, Vergine C. Furniss, Joan D. Hauser
-
Patent number: 6438147Abstract: An external cavity laser system composed of a semiconductor diode laser (10), a temperature control (30) and injection current control (40) means the diode laser, an external cavity (60) with a wavelength selector and means for controlling the laser temperature (20), laser injection current and the wavelength selector (110) to obtain arbitrary frequencies within the tuning range of the laser.Type: GrantFiled: January 26, 1999Date of Patent: August 20, 2002Assignee: Perkin Elmer Instruments LLCInventors: Chandra Roychoudhuri, David H. Tracy, William J. Hubbard
-
Publication number: 20020094578Abstract: Generally, the present invention provides a device and method for accurately locating a multi-well plate at a plate-support location, e.g., a work surface, of an automated laboratory machine, such that one or more acting members of the machine, such as an array of pipette tips, optical sensors, or the like, can accurately address and operate on the individual wells. Interior and/or exterior surface regions of one or more wells of a multi-well plate are used as the primary plate features engaged by locating structure of the machine. In one particular embodiment one or more upwardly tapered projections extend from a plate-support surface of a plate-handling machine for mating engagement with the exterior surface regions of one or more wells. In another embodiment, the exterior surface regions along one or more well bottoms are engagingly received within bores, or other receiving structure, formed on the plate-support surface of a machine.Type: ApplicationFiled: December 6, 2001Publication date: July 18, 2002Applicant: The Perkin-Elmer CorporationInventors: Reid Burton Kowallis, David M. Cox
-
Publication number: 20020081616Abstract: Long wavelength, narrow emission bandwidth fluorecein dyes are provided for detecting spacially overlapping target substances. The dyes comprise 4,7-dichlorofluoresceins, and particularly 2′,4′,5′,7′-tetrachloro-4,7-dichloro-5- (and 6-) carboxyfluoresceins. Methods and kits for using the dyes in DNA analysis are provided.Type: ApplicationFiled: September 7, 2001Publication date: June 27, 2002Applicant: The Perkin-Elmer CorporationInventors: Steven M. Menchen, Linda G. Lee, Charles R. Connell, N. Davis Hershey, Vergine Chakerian, Sam L. Woo, Steven Fung