Patents Assigned to PerkinElmer Health Sciences, Inc.
  • Patent number: 10431444
    Abstract: The present disclosure provides methods and systems for automated analysis of spectrometry data corresponding to particles of a sample, such as large data sets obtained during single particle mode analysis of an inductively coupled plasma mass spectrometer (SP-ICP-MS). Techniques are presented herein that provide appropriate smoothing for rapid data processing without an accompanying reduction (or with an acceptably negligible reduction) in accuracy and/or precision.
    Type: Grant
    Filed: July 28, 2017
    Date of Patent: October 1, 2019
    Assignee: PerkinElmer Health Sciences, Inc.
    Inventors: Samad Bazargan, Hamid Badiei
  • Patent number: 10399030
    Abstract: A Chromatography system that includes a microfluidic device configured to provide three-way switching or switching between three or more inputs or outputs. The microfluidic device fluidically coupled to one or more switching valves to provide for selective control of fluid flow in the chromatography system.
    Type: Grant
    Filed: September 4, 2017
    Date of Patent: September 3, 2019
    Assignee: PerkinElmer Health Sciences, Inc.
    Inventor: Andrew Tipler
  • Patent number: 10395905
    Abstract: Certain embodiments described herein are directed to ion detectors and systems. In some examples, the ion detector can include a plurality of dynodes, in which one or more of the dynodes are coupled to an electrometer. In other configurations, each dynode can be coupled to a respective electrometer. Methods using the ion detectors are also described.
    Type: Grant
    Filed: March 31, 2017
    Date of Patent: August 27, 2019
    Assignee: PERKINELMER HEALTH SCIENCES, INC.
    Inventors: Urs Steiner, Daniel Robert Marshak
  • Patent number: 10379089
    Abstract: Certain configurations described herein are directed to gas chromatography devices. In some instances, the gas chromatography devices may comprise at least one heating device which can be moved along a chromatography column to provide a thermal gradient to the chromatography column. In other instances, the gas chromatography devices may comprise a heating device that can receive a moving chromatography column to provide a thermal gradient to the chromatography column. The gas chromatography devices may be configured as portable devices which can be used to perform remote analyzes.
    Type: Grant
    Filed: October 29, 2016
    Date of Patent: August 13, 2019
    Assignee: PerkinElmer Health Sciences, Inc.
    Inventors: Edgar D Lee, Nathan L Porter, Randal W Waite
  • Patent number: 10375811
    Abstract: Certain embodiments described herein are directed to devices, systems and methods that comprise asymmetric induction devices. In some instances, the device can include a plurality of plate electrodes which can be spaced asymmetrically or a plurality of coils which can be spaced asymmetrically.
    Type: Grant
    Filed: January 6, 2017
    Date of Patent: August 6, 2019
    Assignee: PerkinElmer Health Sciences, Inc.
    Inventor: Peter J Morrisroe
  • Patent number: 10375810
    Abstract: Certain embodiments described herein are directed to devices that can be used to sustain a capacitively coupled plasma. In some examples, a capacitive device can be used to sustain a capacitively coupled plasma in a torch in the absence of any substantial inductive coupling. In certain embodiments, a helium gas flow can be used with the capacitive device to sustain a capacitively coupled plasma.
    Type: Grant
    Filed: October 14, 2016
    Date of Patent: August 6, 2019
    Assignee: PerkinElmer Health Sciences, Inc.
    Inventor: Peter J Morrisroe
  • Patent number: 10368427
    Abstract: Plasma devices and methods for using such plasma devices in analytical measurements are disclosed. In certain examples, a low flow plasma may be operative using a total argon gas flow of less than about five liters per minute, and in some embodiments, a plasma argon gas flow of less than about four liter per minute. In other examples, a plasma produced using inductive and capacitive coupling is disclosed.
    Type: Grant
    Filed: January 19, 2014
    Date of Patent: July 30, 2019
    Assignee: PerkinElmer Health Sciences, Inc.
    Inventor: Peter J Morrisroe
  • Patent number: 10359444
    Abstract: Certain configurations described herein are directed to autosamplers. In some instances, the autosampler may include a support comprising a body configured to receive two or more articles at separate sites of the body. The autosampler may also include a first motor coupled to the support and configured to rotate the support in an x-y plane, and a second motor configured to move the support in a z-direction to load one of the at least two articles at the separate sites in the body of the support. An encoder may also be used with the autosampler if desired.
    Type: Grant
    Filed: May 2, 2016
    Date of Patent: July 23, 2019
    Assignee: PerkinElmer Health Sciences, Inc.
    Inventor: Paul Pieter Willem van Grinsven
  • Patent number: 10327319
    Abstract: Devices, systems and methods using counterflow sample introduction are described. In certain examples, the devices, systems and methods may be configured to introduce a fluid flow comprising a sample into a torch comprising a plasma in a direction that opposes the flow of a gas used to sustain the plasma. Optical emission devices, optical absorption devices and mass spectrometers using the counterflow sample introduction are also described.
    Type: Grant
    Filed: May 24, 2017
    Date of Patent: June 18, 2019
    Assignee: PerkinElmer Health Sciences, Inc.
    Inventor: Peter Morrisroe
  • Patent number: 10309939
    Abstract: Certain embodiments described herein are directed to chromatography systems that include a microfluidic device. The microfluidic device can be fluidically coupled to a switching valve to provide for selective control of fluid flow in the chromatography system. In some examples, the microfluidic device may include a charging chamber, a bypass restrictor or other features that can provide for added control of the fluid flow in the system. Methods of using the devices and methods of calculating lengths and diameters to provide a desired flow rate are also described.
    Type: Grant
    Filed: July 13, 2016
    Date of Patent: June 4, 2019
    Assignee: PerkinElmer Health Sciences, Inc.
    Inventor: Andrew Tipler
  • Patent number: 10290478
    Abstract: Certain embodiments described herein are directed to detectors and systems using them. In some examples, the detector can include a plurality of dynodes, in which one or more of the dynodes are coupled to an electrometer. In some instances, an analog signal from a non-saturated dynode is measured and cross-calibrated with a pulse count signal to extend the dynamic range of the detector.
    Type: Grant
    Filed: June 1, 2016
    Date of Patent: May 14, 2019
    Assignee: PerkinElmer Health Sciences, Inc.
    Inventors: Hamid Badiei, Steven A. Beres
  • Patent number: 10247710
    Abstract: Certain embodiments described herein are directed to chromatography systems that include a microfluidic device and that implement one or more methods to direct sample to a desired fluid flow path. The methods can be used to backflush a sample to a desired fluid flow path to select certain analytes within a sample.
    Type: Grant
    Filed: October 21, 2013
    Date of Patent: April 2, 2019
    Assignee: PerkinElmer Health Sciences, Inc.
    Inventor: Andrew Tipler
  • Patent number: 10229820
    Abstract: Certain embodiments described herein are directed to optical detector and optical systems. In some examples, the optical detector can include a plurality of dynodes, in which one or more of the dynodes are coupled to an electrometer. In other configurations, each dynode can be coupled to a respective electrometer. Methods using the optical detectors are also described.
    Type: Grant
    Filed: June 21, 2016
    Date of Patent: March 12, 2019
    Assignee: PerkinElmer Health Sciences, Inc.
    Inventors: Urs Steiner, Daniel Robert Marshak
  • Patent number: 10222242
    Abstract: Certain configurations described herein are directed to encoders and encoding methods. In some instances, an encoder can be used with an article support to identify an absolute position of the article support based on reading the code of the encoder.
    Type: Grant
    Filed: May 2, 2016
    Date of Patent: March 5, 2019
    Assignee: PerkinElmer Health Sciences, Inc.
    Inventor: Ernst van de Kerkhof
  • Patent number: 10187967
    Abstract: Certain embodiments described herein are directed to a torch that includes a lanthanide or actinide material. In some embodiments, the torch can include one or more other materials in combination with the lanthanide or actinide material. In some embodiments, the torch can comprise cerium, terbium or thorium. In other embodiments, the torch can comprise a lanthanide or actinide material comprising a melting point higher than the melting point of quartz.
    Type: Grant
    Filed: November 2, 2016
    Date of Patent: January 22, 2019
    Assignee: PerkinElmer Health Sciences, Inc.
    Inventor: Peter Morrisroe
  • Patent number: 10184921
    Abstract: A column connection device for use in gas chromatography is disclosed. The column connection device includes a housing with a piston, a piston spring retainer, and disk springs composed of an austenite nickel-chromium-based superalloy (e.g. Special Metals Corp.'s Inconel family of metals). The piston has a ferrule on its exposed end. The disk springs urge the ferrule against the mating portion of an external device maintaining a seal with the external device and creating a seal radially around a column disposed within. The column connection device also includes a release slider and a column base with a column retainer, column tab, and wire springs composed of an austenite nickel-chromium-based superalloy. The wire springs urge the column tab to frictionally engage the column, thereby inhibiting column movement. Depressing the release slider flexes the wire springs, urging the column tab away from the column, removing the frictional inhibition.
    Type: Grant
    Filed: August 7, 2015
    Date of Patent: January 22, 2019
    Assignee: PerkinElmer Health Sciences, Inc.
    Inventor: Timothy P. Neal
  • Patent number: 10181394
    Abstract: The present disclosure provides methods and systems for automated tuning of multimode inductively coupled plasma mass spectrometers (ICP-MS). In certain embodiments, a ‘single click’ optimization method is provided for a multi-mode ICP-MS system that automates tuning of the system in one or more modes selected from among the multiple modes, e.g., a vented cell mode, a reaction cell mode (e.g., dynamic reaction cell mode), and a collision cell mode (e.g., kinetic energy discrimination mode). Workflows and computational routines, including a dynamic range optimization technique, are presented that provide faster, more efficient, and more accurate tuning.
    Type: Grant
    Filed: February 13, 2015
    Date of Patent: January 15, 2019
    Assignee: PerkinElmer Health Sciences, Inc.
    Inventors: Samad Bazargan, Hamid Badiei, Pritesh Patel
  • Patent number: 10178982
    Abstract: Presented herein, in certain embodiments, are approaches for robust bone splitting and segmentation in the context of small animal imaging, for example, microCT imaging. In certain embodiments, a method for calculating and applying single and hybrid second-derivative splitting filters to gray-scale images and binary bone masks is described. These filters can accurately identify the split lines/planes of the bones even for low-resolution data, and hence accurately morphologically disconnect the individual bones. The split bones can then be used as seeds in region growing techniques such as marker-controlled watershed segmentation. With this approach, the bones can be segmented with much higher robustness and accuracy compared to prior art methods.
    Type: Grant
    Filed: May 21, 2018
    Date of Patent: January 15, 2019
    Assignees: PerkinElmer Health Sciences, Inc., PerkinElmer Cellular Technologies Germany GmbH
    Inventors: Ali Behrooz, Peet Kask
  • Patent number: 10145967
    Abstract: Described herein are radiation detection systems and methods that provide improved discrimination between different types of radioactive events. The use of multiple discriminator settings based on pulse curve shape, rather than a single setting, is surprisingly found to improve discrimination between alpha and beta events. Results demonstrate significantly lowered % spill with minimal loss of efficiency due to the enhanced discrimination. These systems and methods are particularly important in the detection of extremely low-level alpha and beta events, and in the identification and quantification of isotopes with difficult-to-distinguish pulse shapes.
    Type: Grant
    Filed: October 28, 2016
    Date of Patent: December 4, 2018
    Assignee: PERKINELMER HEALTH SCIENCES, INC.
    Inventors: Michael Belobraydich, Richard Harazin
  • Patent number: 10136869
    Abstract: Presented herein are efficient and reliable systems and methods for calculating and extracting three-dimensional central axes of bones of animal subjects—for example, animal subjects scanned by in vivo or ex vivo microCT platforms—to capture both the general and localized tangential directions of the bone, along with its shape, form, curvature, and orientation. With bone detection and segmentation algorithms, the skeletal bones of animal subjects scanned by CT or microCT scanners can be detected, segmented, and visualized. Three dimensional central axes determined using these methods provide important information about the skeletal bones.
    Type: Grant
    Filed: March 25, 2016
    Date of Patent: November 27, 2018
    Assignee: PerkinElmer Health Sciences, Inc.
    Inventors: Ali Behrooz, Joshua Kempner