Abstract: Pharmaceutical formulation in the form of a gel suitable for the transdermal administration of an active agent of the class of estrogens or of progestin class or of a mixture of both, comprising:as permeation enhancers of the above said active agents a combination consisting substantially of an aliphatic alcohol having general formula CH3(CH2)nCH20H wherein n=8-16 and of a monoalkylether of diethylene glycol;as a vehicle or carrier, a combination of an alkanol of 2.div.4 C atoms, a glycol and water;as gelling agent a polymer or copolymer of acrylic acid;a tertiary amine as a thickening and neutralizing agent.